Dynamic acoustic field activated cell separation (DAFACS)

Advances in diagnostics, cell and stem cell technologies drive the development of application-specific tools for cell and particle separation. Acoustic micro-particle separation offers a promising avenue for highthroughput, label-free, high recovery, cell and particle separation and isolation in regenerative medicine. Here, we demonstrate a novel approach utilizing a dynamic acoustic field that is capable of separating an arbitrary size range of cells. We first demonstrate the method for the separation of particles with different diameters between 6 and 45 μm and secondly particles of different densities in a heterogeneous medium. The dynamic acoustic field is then used to separate dorsal root ganglion cells. The shearless, label-free and low damage characteristics make this method of manipulation particularly suited for biological applications. Advantages of using a dynamic acoustic field for the separation of cells include its inherent safety and biocompatibility, the possibility to operate over large distances (centimetres), high purity (ratio of particle population, up to 100%), and high efficiency (ratio of separated particles over total number of particles to separate, up to 100%)

Carbon Flashes in the Heavy Element Ocean on Accreting Neutron Stars

We show that burning of a small mass fraction of carbon in a neutron star ocean is thermally unstable at low accumulated masses when the ocean contains heavy ashes from the hydrogen burning rapid proton (rp) process. The key to early unstable ignition is the low thermal conductivity of a heavy element ocean. The instability requires accretion rates in excess of one-tenth the Eddington limit when the carbon mass fraction is 0.1 or less. The unstable flashes release 10^{42} to 10^{43} ergs over hours to days, and are likely the cause of the recently discovered large Type I X-ray bursts (so-called ``superbursts'') from six Galactic low mass X-ray binaries. In addition to explaining the energetics, recurrence times, and durations of the superbursts, these mixed carbon/heavy element flashes have an accretion rate dependence of unstable burning similar to that observed. Though the instability is present at accretion rates near Eddington, there is less contrast with the accretion luminosity there, explaining why most detections are made at accretion rates between 0.1 and 0.3 Eddington. Future comparisons of time dependent calculations with observations will provide new insights into the rp process.Comment: Submitted to Astrophysical Journal Letters (6 pages, 3 figures

SAX J1808.4-3657 in Quiescence: A Keystone for Neutron Star Science

The accreting millisecond pulsar SAX J1808.4-3658 may be a transition object between accreting X-ray binaries and millisecond radio pulsars. We have constrained the thermal radiation from its surface through XMM-Newton X-ray observations, providing strong evidence for neutrino cooling processes from the neutron star core. We have also undertaken simultaneous X-ray and optical (Gemini) observations, shedding light on whether the strong heating of the companion star in quiescence may be due to X-ray irradiation, or to a radio pulsar turning on when accretion stops.Comment: To appear in the proceedings of "Forty Years of Pulsars: Millisecond Pulsars, Magnetars and More" held in Montreal, Canada, August 12-17, 2007. 4 page

Super star clusters in Haro 11: properties of a very young starburst and evidence for a near-infrared flux excess

We have used multiband imaging to investigate the nature of an extreme starburst environment in the nearby Lyman break galaxy analogue Haro 11 (ESO 350−IG038) by means of its stellar cluster population. The central starburst region has been observed in eight different high-resolution Hubble Space Telescope (HST) wavebands, sampling the stellar and gas components from UV to near-infrared. Photometric imaging of the galaxy was also carried out at 2.16 μm by NaCo AO instrument at the ESO Very Large Telescope. We constructed integrated spectral energy distributions (SEDs) for about 200 star clusters located in the active star-forming regions and compared them with single stellar population models (suitable for physical properties of very young cluster population) in order to derive ages, masses and extinctions of the star clusters. The cluster age distribution we recover confirms that the present starburst has lasted for 40 Myr, and shows a peak of cluster formation only 3.5 Myr old. With such an extremely young cluster population, Haro 11 represents a unique opportunity to investigate the youngest phase of the cluster formation process and evolution in starburst systems. We looked for possible relations between cluster ages, extinctions and masses. Extinction tends to diminish as a function of the cluster age, but the spread is large and reaches the highest dispersion for clusters in partial embedded phases (8000 Å which cannot be explained by simple stellar evolutionary models. Fitting SED models over all wavebands leads to systematic overestimates of cluster ages and incorrect masses for the stellar population supplying the light in these clusters. We show that the red excess affects also the HST F814W filter, which is typically used to constrain cluster physical properties. The clusters which show the red excess are younger than 40 Myr; we discuss possible physical explanations for the phenomenon. Finally, we estimate that Haro 11 has produced bound clusters at a rate almost a factor of 10 higher than the massive and regular spirals, like the Milky Way. The present cluster formation efficiency is ∼38 per cent of the galactic star formation rat

Fabrication of integrated planar gunn diode and micro-cooler on GaAs substrate

We demonstrate fabrication of an integrated micro cooler with the planar Gunn diode and characterise its performance. First experimental results have shown a small cooling at the surface of the micro cooler. This is first demonstration of an integrated micro-cooler with a planar Gunn diode

Micro-cooler Enhancements by Barrier Interface Analysis

Peer reviewedPublisher PD

Silicon mirror suspensions for gravitational wave detectors

One of the most significant limits to the sensitivity of current, and future, long-baseline interferometric gravitational wave detectors is thermal displacement noise of the test masses and their suspensions. This paper reports results of analytical and experimental studies of the limits to thermal noise performance of cryogenic silicon test mass suspensions set by two constraints on suspension fibre dimensions: the minimum dimensions required to allow conductive cooling for extracting incident laser beam heat deposited in the mirrors; and the minimum dimensions of fibres (set by their tensile strength) which can support test masses of the size envisaged for use in future detectors. We report experimental studies of breaking strength of silicon ribbons, and resulting design implications for the feasibility of suspension designs for future gravitational wave detectors using silicon suspension fibres. We analyse the implication of this study for thermal noise performance of cryogenically cooled silicon suspensions

Apparatus for dimensional characterization of fused silica fibers for the suspensions of advanced gravitational wave detectors

Detection of gravitational waves from astrophysical sources remains one of the most challenging problems faced by experimental physicists. A significant limit to the sensitivity of future long-baseline interferometric gravitational wave detectors is thermal displacement noise of the test mass mirrors and their suspensions. Suspension thermal noise results from mechanical dissipation in the fused silica suspension fibers suspending the test mass mirrors and is therefore an important noise source at operating frequencies between ∼10 and 30 Hz. This dissipation occurs due to a combination of thermoelastic damping, surface and bulk losses. Its effects can be reduced by optimizing the thermoelastic and surface loss, and these parameters are a function of the cross sectional dimensions of the fiber along its length. This paper presents a new apparatus capable of high resolution measurements of the cross sectional dimensions of suspension fibers of both rectangular and circular cross section, suitable for use in advanced detector mirror suspensions

Spectral Modeling of SNe Ia Near Maximum Light: Probing the Characteristics of Hydro Models

We have performed detailed NLTE spectral synthesis modeling of 2 types of 1-D hydro models: the very highly parameterized deflagration model W7, and two delayed detonation models. We find that overall both models do about equally well at fitting well observed SNe Ia near to maximum light. However, the Si II 6150 feature of W7 is systematically too fast, whereas for the delayed detonation models it is also somewhat too fast, but significantly better than that of W7. We find that a parameterized mixed model does the best job of reproducing the Si II 6150 line near maximum light and we study the differences in the models that lead to better fits to normal SNe Ia. We discuss what is required of a hydro model to fit the spectra of observed SNe Ia near maximum light.Comment: 29 pages, 14 figures, ApJ, in pres

Mitigation of Moral Hazard and Adverse Selection in Venture Capital Financing: The Influence of the Country’s Institutional Setting

A venture capitalist (VC) needs to trade off benefits and costs when attempting to mitigate agency problems in their investor-investee relationship. We argue that signals of ventures complement the VC’s capacity to screen and conduct a due diligence during the pre-investment phase, but its attractiveness may diminish in institutional settings supporting greater transparency. Similarly, whereas a VC may opt for contractual covenants to curb potential opportunism by ventures in the post-investment phase, this may only be effective in settings supportive of shareholder rights enforcement. Using an international sample of VC contracts, our study finds broad support for these conjectures. It delineates theoretical and practical implications for how investors can best deploy their capital in different institutional settings whilst nurturing their relationships with entrepreneurs