A study of the potential interaction of valsartan with some electrolytes

The effect of electrolytes (salts) on the partition coefficient of valsartan was studied at room temperature. The investigation was done by partitioning valsartan between 1-octanol and electrolyte solutions of varying concentrations. It was found that all the electrolytes increased the partition coefficient of the drug except sodium fluoride. The effect was found to depend on the size and charge of the ions present in solution

Studies on the Effects of Electrolytes and pH Control on the Lipophilicity of Fexofenadine Hydrochloride

The effects of electrolytes and pH control on the lipophilic character of fexofenadine hydrochloride was investigated at room temperature. The study was performed by partitioning the drug between 1-octanol and water system. The water system consists of either electrolyte solution of varying concentrations or water adjusted to varying pH values. The most lipophilic effect was observed with aluminum chloride while the least drug lipophilicity was seen with sodium fluoride. The study also showed that pH control had no significant effect on the lipophilicity of fexofenadine hydrochloride.Bio-Research Vol. 6 (1) 2008: pp. 301-30

The Effect of Soya bean (Glycine max) on Pefloxacin Absorption in Rats

The study was to investigate the effect of soya bean on the absorption of pefloxacin when given by oral route in rats. The first group of animals feeding on standard pellet feeds was given pefloxacin (8 mg/kg, p.o), while the second and third groups were also given the drug at the same dosage level but were fed with 50 % and 100 % soya bean respectively. Plasma samples were collected at different time intervals following drug administration. The concentrations of pefloxacin in plasma were determined using spectrophotometric method. Feeds with 50 % and 100 % soya bean respectively, gave significant increase (

The effect of cosolvents and surfactants on the aqueous solubility of Irbesartan

It was considered an interest to enhance the aqueous solubility of irbesartan. To accomplish this objective, the solubilization of irbesartan by cosolvency and micellization was investigated. It was found that all the cosolvents (ethanol, glycerol, propylene glycol) and surfactants (sodium lauryl sulfate,polysorbate-80) increased the solubility of irbesartan. Sodium lauryl sulfate was observed to be the most effective of the solubilizing agents used. The increase in aqueous solubility of irbesartan at the maximum concentration studied was in the following order: sodium lauryl sulfate > polysorbate-80 > ethanol > propylene glycol > glycerol

Identification of the Hydrolytic Degradation Product of Irbesartan in Aqueous Solution

The hydrolytic degradation of irbesartan in borate buffer (pH 9.80) at 70 ± 1° C was studied. The degradation was hydroxide ion catalyzed. The separation of irbesartan from the degraded product was achieved by high performance liquid chromatography. The isolated degraded product was confirmed by its retention time. The characterization was done by elemental and infrared spectroscopic analyses. The characterized degraded product is methyl-biphenyltetrazole.Keywords: hydrolysis, degradation, irbesartan, aqueous solution, bufferNigerian Journal of Pharmaceutical Research, Vol. 8 No 1 pp. 43 - 45 (September 2010

Preliminary Study On The Effect Of Ethanol Extracts Of Chrysophyllum albidum Fruit On Isolated Rat Uterus

The effect of ethanol extracts of Chrysophyllum albidum fruit parts (namely pericarp, mesocarp, seed coat and seed cotyledon) on isolated rat uterus was investigated. The ethanol extracts of pericarp, mesocarp and seed coat were found to have no effect on the rat uterus as well as oxytocin-induced uterine contraction. When compared to isoproterenol, the extracts were observed not to have any uterine relaxant properties. However, the ethanol extract of the seed cotyledon exhibited minimal dose related uterine contraction and was also found to produce a partial increase on the oxytocin-induced uterine contraction. Phytochemical screening showed the presence of alkaloids, flavonoids, saponins, tannins and terpenoids. Keywords:Chrysophyllum albidum, Uterine propertiesPlant Product Research Journal Vol. 12 2008: pp. 4-