1,679 research outputs found
WWP2 ubiquitin ligase and its isoforms: New biological insight and promising disease targets
A number of recent papers on the WWP2 E3 ubiquitin ligase and two novel WWP2 isoforms have revealed important biological insight and disease-specific functions, and also impacted on our understanding of ubiquitin ligases in cell cycle regulation, apoptosis and differentiation. Gene knockout studies suggest a developmental role for WWP2 in chondrogenesis via mechanisms involving cartilage-specific transcription factors. Furthermore, WWP2 isoforms have been shown to selectively target oncogenic signaling pathways linked to both the pTEN tumour suppressor and the TGFß/Smad signaling pathway. Here, it is suggested that WWP2 isoforms have now emerged as central physiological regulators as well as promising new disease targets, and that the challenge ahead is to now develop highly selective WWP2 inhibitors with utility in cartilage disease such as osteoarthritis and as new anticancer strategies
Studying edge geometry in transiently turbulent shear flows
In linearly stable shear flows at moderate Re, turbulence spontaneously
decays despite the existence of a codimension-one manifold, termed the edge of
chaos, which separates decaying perturbations from those triggering turbulence.
We statistically analyse the decay in plane Couette flow, quantify the breaking
of self-sustaining feedback loops and demonstrate the existence of a whole
continuum of possible decay paths. Drawing parallels with low-dimensional
models and monitoring the location of the edge relative to decaying
trajectories we provide evidence, that the edge of chaos separates state space
not globally. It is instead wrapped around the turbulence generating structures
and not an independent dynamical structure but part of the chaotic saddle.
Thereby, decaying trajectories need not cross the edge, but circumnavigate it
while unwrapping from the turbulent saddle.Comment: 11 pages, 6 figure
Universal continuous transition to turbulence in a planar shear flow
We examine the onset of turbulence in Waleffe flow -- the planar shear flow
between stress-free boundaries driven by a sinusoidal body force. By truncating
the wall-normal representation to four modes, we are able to simulate system
sizes an order of magnitude larger than any previously simulated, and thereby
to attack the question of universality for a planar shear flow. We demonstrate
that the equilibrium turbulence fraction increases continuously from zero above
a critical Reynolds number and that statistics of the turbulent structures
exhibit the power-law scalings of the (2+1)-D directed percolation universality
class
Turbulent-laminar patterns in shear flows without walls
Turbulent-laminar intermittency, typically in the form of bands and spots, is
a ubiquitous feature of the route to turbulence in wall-bounded shear flows.
Here we study the idealised shear between stress-free boundaries driven by a
sinusoidal body force and demonstrate quantitative agreement between turbulence
in this flow and that found in the interior of plane Couette flow -- the region
excluding the boundary layers. Exploiting the absence of boundary layers, we
construct a model flow that uses only four Fourier modes in the shear direction
and yet robustly captures the range of spatiotemporal phenomena observed in
transition, from spot growth to turbulent bands and uniform turbulence. The
model substantially reduces the cost of simulating intermittent turbulent
structures while maintaining the essential physics and a direct connection to
the Navier-Stokes equations.
We demonstrate the generic nature of this process by introducing stress-free
equivalent flows for plane Poiseuille and pipe flows which again capture the
turbulent-laminar structures seen in transition.Comment: 13 pages, 9 figure
An investigation into the relationships between the geomagnetic field, cosmic rays and trapped particles by means of the earth satellite Ariel 1
Imperial Users onl
Food Insecurity is Negatively Associated with Exclusive Breastfeeding in Tanzania: A Cross-Sectional Study Among HIV-Positive Women\ud
COSMOGRAIL: the COSmological MOnitoring of GRAvItational Lenses X. Modeling based on high-precision astrometry of a sample of 25 lensed quasars: consequences for ellipticity, shear, and astrometric anomalies
(abridged) Gravitationally lensed quasars can be used as powerful
cosmological and astrophysical probes. We can (i) infer the Hubble constant
based on the time-delay technique, (ii) unveil substructures along the l.o.s.
toward distant galaxies, and (iii) compare the shape and the slope of baryons
and dark matter distributions in galaxies. To reach these goals, we need
high-accuracy astrometry and morphology measurements of the lens. In this work,
we first present new astrometry for 11 lenses with measured time delays. Using
MCS deconvolution on NIC2 HST images, we reached an astrometric accuracy of
about 1-2.5 mas and an accurate shape measurement of the lens galaxy. Second,
we combined these measurements with those of 14 other systems to present new
mass models of these lenses. This led to the following results: 1) In 4
double-image quasars, we show that the influence of the lens environment on the
time delay can easily be quantified and modeled, hence putting these lenses
with high priority for time-delay determination. 2) For quadruple-image
quasars, the difficulty often encountered in reproducing the image positions to
milli-arcsec accuracy (astrometric anomaly) is overcome by explicitly including
the nearest visible galaxy in the model. However, one anomalous system
(J1131-1231) does not show any luminous perturber in its vicinity, and three
others (WFI2026-4536, WFI2033-4723, and B2045+265) have problematic modeling.
These 4 systems are the best candidates for a pertubation by a dark matter
substructure. 3) We find a significant correlation between the PA of the light
and of the mass distributions in lensing galaxies. In contrast with other
studies, we find that the ellipticity of the light and of the mass also
correlate well, suggesting that the overall spatial distribution of matter is
not very different from the baryon distribution in the inner \sim 5 kpc of
lensing galaxies.Comment: Accepted for publication in Astronomy and Astrophysics abridged
abstrac
A comparative study of the NCATE Standards and the Virginia Licensure Regulations for School Personnel with the perceptions of elementary principals and teachers
The purpose of this study was to compare the National Council for the Accreditation of Teacher Education (NCATE) 2000 Standards for Elementary Preparation and the Virginia Licensure Regulations for Elementary Personnel (1998) with the perceptions of principals and teachers in the elementary schools in Chesterfield County, Virginia. The methodology incorporated an exploratory design using qualitative data collection and analyses of surveys of school-based personnel, as well as the NCATE standards and Virginia Licensure Regulations. Specifically, themes were identified through a series of reductions of the terms and phrases contained within the documents and surveys.;The results of this study identified similarities and differences between the perceptions of the school-based individuals and the documents analyzed. Among others, some significant themes that emerged were knowledge of content and pedagogy, assessment, personal and professional skills, and authentic experiences
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