8,214 research outputs found
Looking for Design in Materials Design
Despite great advances in computation, materials design is still science
fiction. The construction of structure-property relations on the quantum scale
will turn computational empiricism into true design.Comment: 3 pages, 1 figur
Towards Real-Time Detection and Tracking of Spatio-Temporal Features: Blob-Filaments in Fusion Plasma
A novel algorithm and implementation of real-time identification and tracking
of blob-filaments in fusion reactor data is presented. Similar spatio-temporal
features are important in many other applications, for example, ignition
kernels in combustion and tumor cells in a medical image. This work presents an
approach for extracting these features by dividing the overall task into three
steps: local identification of feature cells, grouping feature cells into
extended feature, and tracking movement of feature through overlapping in
space. Through our extensive work in parallelization, we demonstrate that this
approach can effectively make use of a large number of compute nodes to detect
and track blob-filaments in real time in fusion plasma. On a set of 30GB fusion
simulation data, we observed linear speedup on 1024 processes and completed
blob detection in less than three milliseconds using Edison, a Cray XC30 system
at NERSC.Comment: 14 pages, 40 figure
Average-Case Optimal Approximate Circular String Matching
Approximate string matching is the problem of finding all factors of a text t
of length n that are at a distance at most k from a pattern x of length m.
Approximate circular string matching is the problem of finding all factors of t
that are at a distance at most k from x or from any of its rotations. In this
article, we present a new algorithm for approximate circular string matching
under the edit distance model with optimal average-case search time O(n(k + log
m)/m). Optimal average-case search time can also be achieved by the algorithms
for multiple approximate string matching (Fredriksson and Navarro, 2004) using
x and its rotations as the set of multiple patterns. Here we reduce the
preprocessing time and space requirements compared to that approach
Eosinophil and T Cell Markers Predict Functional Decline in COPD Patients
BACKGROUND. The major marker utilized to monitor COPD patients is forced expiratory volume in one second (FEV1). However, asingle measurement of FEV1 cannot reliably predict subsequent decline. Recent studies indicate that T lymphocytes and eosinophils are important determinants of disease stability in COPD. We therefore measured cytokine levels in the lung lavage fluid and plasma of COPD patients in order to determine if the levels of T cell or eosinophil related cytokines were predictive of the future course of the disease. METHODS. Baseline lung lavage and plasma samples were collected from COPD subjects with moderately severe airway obstruction and emphysematous changes on chest CT. The study participants were former smokers who had not had a disease exacerbation within the past six months or used steroids within the past two months. Those subjects who demonstrated stable disease over the following six months (ΔFEV1 % predicted = 4.7 ± 7.2; N = 34) were retrospectively compared with study participants who experienced a rapid decline in lung function (ΔFEV1 % predicted = -16.0 ± 6.0; N = 16) during the same time period and with normal controls (N = 11). Plasma and lung lavage cytokines were measured from clinical samples using the Luminex multiplex kit which enabled the simultaneous measurement of several T cell and eosinophil related cytokines. RESULTS AND DISCUSSION. Stable COPD participants had significantly higher plasma IL-2 levels compared to participants with rapidly progressive COPD (p = 0.04). In contrast, plasma eotaxin-1 levels were significantly lower in stable COPD subjects compared to normal controls (p < 0.03). In addition, lung lavage eotaxin-1 levels were significantly higher in rapidly progressive COPD participants compared to both normal controls (p < 0.02) and stable COPD participants (p < 0.05). CONCLUSION. These findings indicate that IL-2 and eotaxin-1 levels may be important markers of disease stability in advanced emphysema patients. Prospective studies will need to confirm whether measuring IL-2 or eotaxin-1 can identify patients at risk for rapid disease progression.National Heart, Lung, and Blood Institute (NO1-HR-96140, NO1-HR-96141-001, NO1-HR-96144, NO1-HR-96143; NO1-HR-96145; NO1-HR-96142, R01HL086936-03); The Flight Attendant Medical Research Institute; the Jo-Ann F. LeBuhn Center for Chest Diseas
On the stability of fissured slopes subject to seismic action
A set of analytical solutions achieved by the upper bound theorem of limit analysis and the pseudo-static approach is presented for the assessment of the stability of homogeneous c, Ï• slopes manifesting vertical cracks and subject to seismic action. Rotational failure mechanisms are considered for slopes with cracks of either known or unknown depth and location. A validation exercise was carried out based on numerical limit analyses and displacement-based finite-element analyses with strength reduction technique.
Charts providing the stability factor for fissured slopes subject to both horizontal and vertical accelerations for any combination of c, Ï• and slope inclination are provided. The effect of the direction of the vertical acceleration on slope stability is specifically analysed. Yield seismic coefficients are also provided.
When the presence of cracks within the slope can be ascertained with reasonable confidence, maps showing the zones within the slope where they have no destabilising effect are provided.
Finally, Newmark's method was employed to assess the effect of cracks on earthquake induced displacements. To this end, displacement coefficients are provided in chart form as a function of the slope characteristics. Two examples of slopes subjected to known earthquakes are illustrated
Complex Deleterious Interactions Associated with Malic Enzyme May Contribute to Reproductive Isolation in the Copepod Tigriopus californicus
Dobzhansky-Muller incompatibilities can result from the interactions of more than a single pair of interacting genes and there are several different models of how such complex interactions can be structured. Previous empirical work has identified complex conspecific epistasis as a form of complex interaction that has contributed to postzygotic reproductive isolation between taxa, but other forms of complexity are also possible. Here, I probe the genetic basis of reproductive isolation in crosses of the intertidal copepod Tigriopus californicus by looking at the impact of markers in genes encoding metabolic enzymes in F2 hybrids. The region of the genome associated with the locus ME2 is shown to have strong, repeatable impacts on the fitness of hybrids in crosses and epistatic interactions with another chromosomal region marked by the GOT2 locus in one set of crosses. In a cross between one of these populations and a third population, these two regions do not appear to interact despite the continuation of a large effect of the ME2 region itself in both crosses. The combined results suggest that the ME2 chromosomal region is involved in incompatibilities with several unique partners. If these deleterious interactions all stem from the same factor in this region, that would suggest a different form of complexity from complex conspecific epistasis, namely, multiple independent deleterious interactions stemming from the same factor. Confirmation of this idea will require more fine-scale mapping of the interactions of the ME2 region of the genome
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G-Protein coupled receptors: structure and function in drug discovery
The G-protein coupled receptors (GPCRs) superfamily comprise similar proteins arranged into families or classes thus making it one of the largest in the mammalian genome. GPCRs take part in many vital physiological functions making them targets for numerous novel drugs. GPCRs share some distinctive features, such as the seven transmembrane domains, they also differ in the number of conserved residues in their transmembrane domain. Here we provide an introductory and accessible review detailing the computational advances in GPCR pharmacology and drug discovery. An overview is provided on family A-C GPCRs; their structural differences, GPCR signalling, allosteric binding and cooperativity. The dielectric constant (relative permittivity) of proteins is also discussed in the context of site-specific environmental effects
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