24 research outputs found

    Variants of ST8SIA1 Are Associated with Risk of Developing Multiple Sclerosis

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    Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system of unknown etiology with both genetic and environmental factors playing a role in susceptibility. To date, the HLA DR15/DQ6 haplotype within the major histocompatibility complex on chromosome 6p, is the strongest genetic risk factor associated with MS susceptibility. Additional alleles of IL7 and IL2 have been identified as risk factors for MS with small effect. Here we present two independent studies supporting an allelic association of MS with polymorphisms in the ST8SIA1 gene, located on chromosome 12p12 and encoding ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1. The initial association was made in a single three-generation family where a single-nucleotide polymorphism (SNP) rs4762896, was segregating together with HLA DR15/DQ6 in MS patients. A study of 274 family trios ( affected child and both unaffected parents) from Australia validated the association of ST8SIA1 in individuals with MS, showing transmission disequilibrium of the paternal alleles for three additional SNPs, namely rs704219, rs2041906, and rs1558793, with p = 0.001, p = 0.01 and p = 0.01 respectively. These findings implicate ST8SIA1 as a possible novel susceptibility gene for MS

    Spin-dependent trapping of electrons at spinterfaces

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    Hybrid ferromagnetic metal/organic interfaces—also known as spinterfaces—can exhibit highly efficient spin-filtering properties and therefore present a promising class of materials for the future development of new spintronic devices. Advancing the field depends critically on elucidating the fundamental microscopic processes that eventually determine the spin-filtering properties in such hybrid structures. Here, we study the femtosecond spin dynamics at the prototypical interface between cobalt and the metalorganic complex tris(8-hydroxyquinolinato)aluminium. To disentangle the microscopic origin of spin filtering, we optically generate a transient spin polarization in a well-defined hybrid interface state that we follow with a spin-resolved real-time pump–probe two-photon photoemission experiment. We find that the electrons are trapped at the interface in a spin-dependent manner for a surprisingly long time of the order of 0.5–1 ps. We conclude that ferromagnetic metal/organic interfaces act as spin filters because electrons are trapped in hybrid interface states by spin-dependent confining potentials. In conventional spintronics, control over electron spin inelectrical transport has led to the impressive magneto-resistivedevices that are used for data storage and magnetic sensing1. The development of new and more versatile spintronics devices over recent years, however, has shown the need to more directly manipulate the electron spin. The wide range of available chemical functionality of organic semiconductors and the ability t
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