A Multifunctional Processing Board for the Fast Track Trigger of the H1 Experiment

The electron-proton collider HERA is being upgraded to provide higher luminosity from the end of the year 2001. In order to enhance the selectivity on exclusive processes a Fast Track Trigger (FTT) with high momentum resolution is being built for the H1 Collaboration. The FTT will perform a 3-dimensional reconstruction of curved tracks in a magnetic field of 1.1 Tesla down to 100 MeV in transverse momentum. It is able to reconstruct up to 48 tracks within 23 mus in a high track multiplicity environment. The FTT consists of two hardware levels L1, L2 and a third software level. Analog signals of 450 wires are digitized at the first level stage followed by a quick lookup of valid track segment patterns. For the main processing tasks at the second level such as linking, fitting and deciding, a multifunctional processing board has been developed by the ETH Zurich in collaboration with Supercomputing Systems (Zurich). It integrates a high-density FPGA (Altera APEX 20K600E) and four floating point DSPs (Texas Instruments TMS320C6701). This presentation will mainly concentrate on second trigger level hardware aspects and on the implementation of the algorithms used for linking and fitting. Emphasis is especially put on the integrated CAM (content addressable memory) functionality of the FPGA, which is ideally suited for implementing fast search tasks like track segment linking.Comment: 6 pages, 4 figures, submitted to TN

Radix Conversion for IEEE754-2008 Mixed Radix Floating-Point Arithmetic

Conversion between binary and decimal floating-point representations is ubiquitous. Floating-point radix conversion means converting both the exponent and the mantissa. We develop an atomic operation for FP radix conversion with simple straight-line algorithm, suitable for hardware design. Exponent conversion is performed with a small multiplication and a lookup table. It yields the correct result without error. Mantissa conversion uses a few multiplications and a small lookup table that is shared amongst all types of conversions. The accuracy changes by adjusting the computing precision

Stable expression of Escherichia coli {beta}-glucuronidase A (GusA) in Giardia lamblia: application to high-throughput drug susceptibility testing

Objectives In order to create a suitable model for high-throughput drug screening, a Giardia lamblia WB C6 strain expressing Escherichia coli glucuronidase A (GusA) was created and tested with respect to susceptibility to the anti-giardial drugs nitazoxanide and metronidazole. Methods GusA, a well-established reporter gene in other systems, was cloned into the vector pPacVInteg allowing stable expression in G. lamblia under control of the promoter from the glutamate dehydrogenase (gdh) gene. The resulting transgenic strain was compared with the wild-type strain in a vitality assay, characterized with respect to susceptibility to nitazoxanide, metronidazole and-as assessed in a 96-well plate format-to a panel of 15 other compounds to be tested for anti-giardial activity. Results GusA was stably expressed in G. lamblia. Using a simple glucuronidase assay protocol, drug efficacy tests yielded results similar to those from cell counting. Conclusions G. lamblia WB C6 GusA is a suitable tool for high-throughput anti-giardial drug screening

Why Some Interfaces Cannot be Sharp

A central goal of modern materials physics and nanoscience is control of materials and their interfaces to atomic dimensions. For interfaces between polar and non-polar layers, this goal is thwarted by a polar catastrophe that forces an interfacial reconstruction. In traditional semiconductors this reconstruction is achieved by an atomic disordering and stoichiometry change at the interface, but in multivalent oxides a new option is available: if the electrons can move, the atoms don`t have to. Using atomic-scale electron energy loss spectroscopy we find that there is a fundamental asymmetry between ionically and electronically compensated interfaces, both in interfacial sharpness and carrier density. This suggests a general strategy to design sharp interfaces, remove interfacial screening charges, control the band offset, and hence dramatically improving the performance of oxide devices.Comment: 12 pages of text, 6 figure

Fluctuation Dominated Josephson Tunneling with a Scanning Tunneling Microscope

We demonstrate Josephson tunneling in vacuum tunnel junctions formed between a superconducting scanning tunneling microscope tip and a Pb film, for junction resistances in the range 50-300 k$\Omega$. We show that the superconducting phase dynamics is dominated by thermal fluctuations, and that the Josephson current appears as a peak centered at small finite voltages. In the presence of microwave fields (f=15.0 GHz) the peak decreases in magnitude and shifts to higher voltages with increasing rf power, in agreement with theory.Comment: 4 pages, REVTeX, submitted to PR

Is the association between blood pressure and cognition in the oldest-old modified by physical, vascular or brain pathology markers? The EMIF-AD 90 + Study

BACKGROUND: Prior studies suggest a changing association between blood pressure (BP) and cognition with aging, however work in the oldest-old has yielded ambiguous results. Potentially, these mixed results can be explained by modifying factors. The aim of this study was to establish whether physical, vascular or brain pathology markers that describe a state of increased vulnerability, affect the association between BP and cognition in the oldest-old. Results may influence clinicians’ decisions regarding the use of antihypertensives in this age group. METHODS: We included 122 individuals (84 without cognitive impairment and 38 with cognitive impairment) from the EMIF-AD 90 + Study (mean age 92.4 years). First, we tested cross-sectional associations of systolic and diastolic BP with a cognitive composite score. Second, we tested whether these associations were modified by physical markers (waist circumference, muscle mass, gait speed and handgrip strength), vascular markers (history of cardiac disease, carotid intima media thickness as a proxy for atherosclerosis and carotid distensibility coefficient as a proxy for arterial stiffness) or brain pathology markers (white matter hyperintensities and cortical thickness). RESULTS: In the total sample, there was no association between BP and cognition, however, waist circumference modified this association (p-value for interaction with systolic BP: 0.03, with diastolic BP: 0.01). In individuals with a high waist circumference, higher systolic and diastolic BP tended to be associated with worse cognition, while in individuals with a low waist circumference, higher systolic BP was associated with better cognition. The others physical, vascular and brain pathology markers did not modify the association between BP and cognition. CONCLUSIONS: When examining various markers for physical, vascular and brain vulnerability, only waist circumference affected the association between BP and cognition. This warrants further research to evaluate whether waist circumference may be a marker in clinical practice influencing the use of antihypertensives in the oldest-old

The Digital Elevation Model Intercomparison eXperiment DEMIX, a community-based approach at global DEM benchmarking

This paper presents an initiative recently launched under the auspices of the Committee on Earth Observation Satellites (CEOS) aiming at providing harmonised terminology and methods, as well as practical guidelines and results allowing the intercomparison of continental or global Digital Elevation Models (DEM). As the work is still ongoing the main purpose of this article is not the dissemination of the outcome but rather to inform the wider community about the initiative, communicate the chosen approach to raise awareness, and attract possible further participants. Nevertheless, some preliminary results are included and an outlook on planned next steps is provided