Information-sharing and decision-making in networks of radiation detectors

A network of sensors observes a time-inhomo-geneous Poisson signal and within a fixed time interval has to decide between two hypotheses regarding the signal’s intensity. The paper reveals an interplay between network topology, essentially determining the quantity of information available to different sensors, and the quality of individual sensor information as captured by the sensor’s likelihood ratio. Armed with analytic expressions of bounds on the error probabilities associated with the binary hypothesis test regarding the intensity of the observed signal, the insight into the interplay between sensor communication and data quality helps in deciding which sensor is better positioned to make a decision on behalf of the network, and links the analysis to network centrality concepts. The analysis is illustrated on networked radiation detection examples, first in simulation and then on cases utilizing field measurement data available through a U.S. Domestic Nuclear Detection Office (dndo) database.by Indrajeet Yadav, Chetan D. Pahlajani,Herbert G. and TannerIoannis Poulakaki

Developments in the Treatment of Locally Advanced and Metastatic Squamous Cell Carcinoma of the Skin: A Rising Unmet Need

Squamous cell carcinoma of the skin (SCCS) is a common malignancy with potentially devastating consequences in patients with locally advanced or metastatic disease. Its rising incidence, primarily a result of an aging population and increased ultraviolet (UV) radiation exposure, characterize an emerging unmet need. A firm understanding of the biology of this disease, likely distinct from that of other squamous malignancies because of the influence of UV radiation, is necessary in the evaluation of treatment paradigms. Careful recognition of high-risk features pertaining to tumor and host characteristics is paramount to proper management. However, a lack of standardization in guidelines in this regard creates a challenge for physicians. Questions persist regarding additional evaluation and treatment for advanced disease such as the roles for sentinel lymph node biopsy and the adjuvant use of radiation and chemotherapy. With respect to advanced disease, multiple combinations of chemotherapy have been tested with variable success, but no rigorous randomized studies have been conducted. In addition, EGFR inhibitors such as cetuximab and erlotinib have displayed antitumor activity and as such, warrant further investigation. In sum, the treatment of locally advanced and metastatic SCCS is a ripe area for clinical investigation. This article summarizes the current understanding of disease biology and emerging questions in the management of this disease