Multidimensional treatment foster care for preschoolers: early findings of an implementation in the Netherlands

Multidimensional Treatment Foster Care (MTFC) has been shown to be an evidence based alternative to residential rearing and an effective method to improve behavior and attachment of preschool foster children in the US. This preliminary study investigated an application of MTFC for preschoolers (MTFC-P) in the Netherlands focusing on behavioral outcomes in course of the intervention. To examine the following hypothesis: “the time in the MTFC-P intervention predicts a decline in problem behavior, as this is the desired outcome for children assigned to MTFC-P”, we assessed the daily occurrence of 38 problem behaviors via telephone interviews. Repeated measures revealed significant reduced problem behavior in course of the program. MTFC-P promises to be a treatment model suitable for high-risk foster children, that is transferable across centres and countries

Discovery and replication of SNP-SNP interactions for quantitative lipid traits in over 60,000 individuals

Background The genetic etiology of human lipid quantitative traits is not fully elucidated, and interactions between variants may play a role. We performed a gene-centric interaction study for four different lipid traits: low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), total cholesterol (TC), and triglycerides (TG). Results Our analysis consisted of a discovery phase using a merged dataset of five different cohorts (n = 12,853 to n = 16,849 depending on lipid phenotype) and a replication phase with ten independent cohorts totaling up to 36,938 additional samples. Filters are often applied before interaction testing to correct for the burden of testing all pairwise interactions. We used two different filters: 1. A filter that tested only single nucleotide polymorphisms (SNPs) with a main effect of p < 0.001 in a previous association study. 2. A filter that only tested interactions identified by Biofilter 2.0. Pairwise models that reached an interaction significance level of p < 0.001 in the discovery dataset were tested for replication. We identified thirteen SNP-SNP models that were significant in more than one replication cohort after accounting for multiple testing. Conclusions These results may reveal novel insights into the genetic etiology of lipid levels. Furthermore, we developed a pipeline to perform a computationally efficient interaction analysis with multi-cohort replication

Lipids, obesity and gallbladder disease in women: insights from genetic studies using the cardiovascular gene-centric 50K SNP array

Gallbladder disease (GBD) has an overall prevalence of 10-40% depending on factors such as age, gender, population, obesity and diabetes, and represents a major economic burden. Although gallstones are composed of cholesterol by-products and are associated with obesity, presumed causal pathways remain unproven, although BMI reduction is typically recommended. We performed genetic studies to discover candidate genes and define pathways involved in GBD. We genotyped 15,241 women of European ancestry from three cohorts, including 3216 with GBD, using the Human cardiovascular disease (HumanCVD) BeadChip containing up to ~ 53,000 single-nucleotide polymorphisms (SNPs). Effect sizes with P-values for development of GBD were generated. We identify two new loci associated with GBD, GCKR rs1260326:T>C (P = 5.88 × 10(-7), ß = -0.146) and TTC39B rs686030:C>A (P = 6.95 x 10(-7), ß = 0.271) and detect four independent SNP effects in ABCG8 rs4953023:G>A (P=7.41 × 10(-47), ß = 0.734), ABCG8 rs4299376:G(>)T (P = 2.40 × 10(-18), ß = 0.278), ABCG5 rs6544718:T>C (P = 2.08 × 10(-14), ß = 0.044) and ABCG5 rs6720173:G>C (P = 3.81 × 10(-12), ß(=)0.262) in conditional analyses taking genotypes of rs4953023:G>A as a covariate. We also delineate the risk effects among many genotypes known to influence lipids. These data, from the largest GBD genetic study to date, show that specific, mainly hepatocyte-centred, components of lipid metabolism are important to GBD risk in women. We discuss the potential pharmaceutical implications of our findings

Grupoterapia cognitivo-comportamental para crianças e adolescentes vítimas de abuso sexual Terapia de grupo congnitivo-comportamental para niñas y adolescentes víctimas de abuso sexual Cognitive behavioral group therapy for sexually abused girls

OBJETIVO: Avaliar os efeitos do modelo de grupoterapia cognitivo-comportamental para crianças e adolescentes do sexo feminino vítimas de abuso sexual. MÉTODOS: Foi utilizado delineamento não-randomizado intragrupos de séries temporais. Crianças e adolescentes do sexo feminino com idade entre nove e 16 anos (N=40) da região metropolitana de Porto Alegre (RS), foram clinicamente avaliadas em três encontros individuais, de 2006 a 2008. A grupoterapia consistiu de 16 sessões semi-estruturadas. Instrumentos psicológicos investigaram sintomas de ansiedade, depressão, transtorno do estresse pós-traumático, stress infantil e crenças e percepções da criança em relação à experiência abusiva antes, durante e após a intervenção. Os resultados foram analisados por meio de testes estatísticos para medidas repetidas. Foi realizada uma análise comparativa dos resultados do pré-teste entre os grupos que receberam atendimento psicológico em grupo imediato após a denúncia do abuso e aquelas que aguardaram por atendimento. RESULTADOS: A análise do impacto da intervenção revelou que a grupoterapia cognitivo-comportamental reduziu significativamente sintomas de depressão, ansiedade, stress infantil e transtorno do estresse pós-traumático. Além disso, a intervenção contribuiu para a reestruturação de crenças de culpa, baixa confiança e credibilidade, sendo efetivo para a redução de sintomas psicológicos e alteração de crenças e percepções distorcidas sobre o abuso. CONCLUSÕES: A grupoterapia cognitivo-comportamental mostrou ser efetiva para a redução de sintomas psicológicos de crianças e adolescentes vítimas de abuso sexual.<br>OBJETIVO: Evaluar los efectos del modelo de terapia de grupo cognitivo-comportamental para niñas y adolescentes del sexo femenino víctimas de abuso sexual. MÉTODOS: Fue utilizado delineamiento no aleatorio intragrupos de series temporales. Niños y adolescentes del sexo femenino con edad entre nueve y 16 años (N=40) de la región metropolitana de Porto Alegre (Sur de Brasil), fueron clínicamente evaluadas en tres encuentros individuales, de 2006 a 2008. La terapia de grupo consistió de 16 sesiones semi-estructuradas. Instrumentos psicológicos investigaron síntomas de ansiedad, depresión, trastorno del estrés post-traumático, estrés infantil y creencias y percepciones del niño con relación a la experiencia abusiva antes, durante y posterior a la intervención. Los resultados fueron analizados por medio de pruebas estadísticas para medidas repetidas. Fue realizado un análisis comparativo de los resultados de la pre-evaluación entre los grupos que recibieron atención psicológica en grupo inmediato posterior a la denuncia del abuso y aquellas que aguardaron por atención. RESULTADOS: El análisis del impacto de la intervención reveló que la terapia de grupo cognitivo-comportamental redujo significativamente síntomas de depresión, ansiedad, estrés infantil y trastorno del estrés post-traumático. Adicionalmente, la intervención contribuyó para la reestructuración de creencias de culpa, baja confianza y credibilidad, siendo efectivo para la reducción de síntomas psicológicos y alteración de creencias y percepciones distorsionadas sobre el abuso. CONCLUSIONES: La terapia de grupo cognitivo-comportamental mostró ser efectiva para la reducción de síntomas psicológicos de niños y adolescentes víctimas de abuso sexual.<br>OBJECTIVE: To assess the effects of a cognitive behavioral group therapy model among female children and adolescents victims of sexual abuse. METHODS: A non-randomized study with intragroup comparisons over time was carried out. Female children and teenagers from nine to 16 years of age (N=40) were clinically assessed in three individual meetings in the metropolitan area of Porto Alegre, Southern Brazil, between 2006 and 2008. The group therapy comprised 16 semi-structured sessions. Psychological instruments were applied to investigate symptoms of anxiety, depression, post-traumatic stress disorder, child stress, beliefs and perception of the abuse experience before, during and after the intervention. The results were analyzed through statistical tests for repeated measures. A comparative analysis was carried out with the results of the pretest between the groups that received group psychotherapy immediately after the sexual abuse was reported and those who were waiting for psychological support. RESULTS: The assessment of the impact of the intervention revealed that cognitive behavioral group therapy significantly reduced symptoms of depression, anxiety, child stress and post-traumatic stress disorder. In addition, the intervention enabled the participants to modify beliefs of guilt, low degrees of trust and credibility, and was effective in reducing psychological symptoms and changing distorted beliefs and perception in regard to the abuse. CONCLUSIONS: Cognitive behavioral group therapy was effective in reducing psychological symptoms in sexually abused girls

Mindfulness as Mediator and Moderator of Post-traumatic Symptomatology in Adolescence Following Childhood Sexual Abuse or Assault

Childhood sexual abuse or assault (CSA) is a non-specific risk factor for psychopathology such as post-traumatic stress disorder or depression. However, the impact of CSA greatly varies among individuals. Mediating mechanisms and moderating factors have been proposed to explain how the effects of CSA translate into varied symptoms. Mindfulness is one of the potential variables linked to the diversity of outcomes of CSA. As mindfulness-based interventions are increasingly being used among adolescents and those sexually abused or assaulted in childhood, it is essential to know more about the mechanisms by which it influences post-traumatic symptoms in these populations. This study’s aim is to assess whether mindfulness mediates and moderates the relationship between self-reported exposure to CSA and post-traumatic symptoms in adolescence. A sample of 246 adolescents (48 % female) reported their exposure to CSA and completed the Child Acceptance and Mindfulness Measure and the Trauma Symptoms Checklist for Children. The relation between CSA, mindfulness and post-traumatic symptoms was investigated using mediation and moderation regression models from the Process script. Results reveal that mindfulness acted as a mediator of post-traumatic symptoms, as CSA was associated with lower levels of mindfulness, which in turn were associated with more post-traumatic symptoms. On the other hand, mindfulness only acted as a moderator of CSA for anger and anxiety but not in the expected direction. Further investigation is needed to shed light on the moderator role of mindfulness in sexually abused youth

Discovery and replication of SNP-SNP interactions for quantitative lipid traits in over 60,000 individuals.

Background The genetic etiology of human lipid quantitative traits is not fully elucidated, and interactions between variants may play a role. We performed a gene-centric interaction study for four different lipid traits: low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), total cholesterol (TC), and triglycerides (TG). Results Our analysis consisted of a discovery phase using a merged dataset of five different cohorts (n = 12,853 to n = 16,849 depending on lipid phenotype) and a replication phase with ten independent cohorts totaling up to 36,938 additional samples. Filters are often applied before interaction testing to correct for the burden of testing all pairwise interactions. We used two different filters: 1. A filter that tested only single nucleotide polymorphisms (SNPs) with a main effect of p &lt; 0.001 in a previous association study. 2. A filter that only tested interactions identified by Biofilter 2.0. Pairwise models that reached an interaction significance level of p &lt; 0.001 in the discovery dataset were tested for replication. We identified thirteen SNP-SNP models that were significant in more than one replication cohort after accounting for multiple testing. Conclusions These results may reveal novel insights into the genetic etiology of lipid levels. Furthermore, we developed a pipeline to perform a computationally efficient interaction analysis with multi-cohort replication.</p

Interparental Violence and the Mediating Role of Parental Availability in Children’s Trauma Related Symptoms

This cross-sectional study examined the hypothesis that parental psychopathology in Interparental Violence (IPV) families crosses over to children, because parental psychopathology spills over to parental functioning. In a high-risk sample of IPV exposed families, we tested whether parental psychopathology spills over to parental availability, which, in turn, shows a crossover effect to children's trauma-related symptoms. The study population consisted of 78 IPV exposed children (4-12 years), and their 65 custodial parents referred to outpatient Children's Trauma Centers in the Netherlands for intervention. Consistent with our hypotheses, parental psychopathology was negatively related to parental availability, suggesting a spillover effect. Although parental psychopathology was not associated with children's trauma-related symptoms directly, we found evidence for the predicted indirect, crossover effects. We found an indirect crossover effect from parental psychopathology to children's trauma-related anxiety, depression, and anger, through the spillover effect of parental availability. Clinical implications for treatment and study limitations are discussed

Effects of Multidimensional Treatment Foster Care for Preschoolers (MTFC-P) for Young Foster Children with Severe Behavioral Disturbances

Multidimensional Treatment Foster Care for Preschoolers (MTFC-P) has thus far only been tested for diminishing behavior problems in the US. This study tested relative efficacy of MTFC-P on multiple outcomes against treatment as usual in the Netherlands (TAU; Study I), and regular foster care (Study II). The sample included 55 children that received MTFC-P, 23 children received TAU and 30 children from regular foster care (RFC). Changes in behavioral and relationship functioning, trauma symptoms, hypothalamic-adrenal-pituitary (HPA-) axis functioning, and caregiving stress were assessed via questionnaires, interviews, and salivary cortisol. Outcomes of Study I were evaluated using a randomized controlled design and quasi-experimental design, outcomes of Study II according to non-equivalent group comparison. No evidence was found for relative efficacy of MTFC-P over TAU. A treatment effect was found on trauma symptoms, in favor of TAU. Outcomes of Study II revealed that whereas caregiving stress and secure base distortions were significantly more severe at baseline in MTFC-P compared to RFC, post treatment differences were no longer significant. However, percentages of symptoms of disinhibited attachment and attachment disorder were nearly equal between groups at baseline, while post treatment percentages indicated significantly more symptoms in MTFC. In addition, results revealed a significant difference in the severity of externalizing problems post treatment, in favor of RFC. The results obtained within this study indicate that children in MTFC-P and usual treatment foster care in the Dutch context improved similarly, thus not showing the same advantages that MTFC-P has demonstrated in the US. Results should be interpreted with caution due to lower than planned power. Findings underscore the challenges of testing novel treatments across contexts with highly different child welfare provisions