Dispositio come carattere e identità dell'opera

Ancora un numero di FAMagazine [1] sulla dipositio, ancora a partire da Vitruvio, ancora una riflessione su alcuni termini e procedure centrali della composizione architettonica qui sondati nella relazione tra la diposizione, il carattere e l’identità dell’opera. Nella voce “dipositio” dell’Enciclopedia dell’Arte Antica Treccani l’archeologo e storico dell’arte Silvi

The architectural project as a link between theory and practice

The paper aims to investigate the theme of the Call, the distinction between theory and practice, based on a reflection on Architecture and demonstrating that one of the specifics of this art of construction – or artistic practice as in the well-known definition by Vittorio Gregotti – is in the relationship between thought and artefact intended not in antithetic terms but of hermeneutic circularity. The investigation of points of view and the analysis of exempla are, respectively, premise and demonstration of a reasoning that aims to define, specifically referring to methods and techniques within a theory of architectural design, an “orientated point of view” starting from which a reflection on the relationship between theory and practice is proposed.

Napoli, incessanti latomie tra costruzione e forma del vuoto

Il saggio indaga il rapporto singolare di Napoli tra il ‘sotto’ e il ‘sopra’, in cui lo scavo diviene condizione di possibilità della costruzione della città ma anche inedita spazialità determinata dalle tecniche di tomia del banco tufaceo. Sono descritti alcuni snodi di tale rapporto: dalla fondazione mitica della Parthenope greca o dalle cave e antri cumani alle grandi costruzioni tecniche romane; dalle riproposizioni illuministe ai più recenti riusi/abusi o l’assunzione di tali strutture formali come fonte d’ispirazione tra evocazioni mnemoniche (Venezia), risignificazioni di spazialità riabitate (Aymonino) sino alla riemersione di strutture osteoniche soggiacenti (Rossi)

Where Morphological and Molecular Classifications Meet: The Role of p53 Immunohistochemistry in the Prognosis of Low-Risk Endometrial Carcinoma (GLAMOUR Study)

Simple Summary There is a lack of literature on the role of molecular classification in patients with morphological low-risk EC. We aimed to evaluate the incidence and prognostic role of p53 mutations in this specific subgroup of patients. Our findings show that 4.9% of low-risk EC are p53abn; the OR for the recurrence of p53abn versus p53wt patients was 5.23-CI 95% 0.98-27.95, p = 0.053. No difference in OS was observed between the two groups. Recurrences were mostly local and occur two years after diagnosis. Our data might serve as a valuable tool for clinicians' everyday practice, but larger prospective studies are urgently needed.Abstract No prospective study has validated molecular classification to guide adjuvant treatment in endometrial cancer (EC), and not even retrospective data are present for patients with morphological low-risk EC. We conducted a retrospective, multicenter, observational study including 370 patients with low-risk endometrioid EC to evaluate the incidence and prognostic role of p53 abnormal expression (p53abn) in this specific subgroup. Among 370 patients, 18 had abnormal expressions of p53 (4.9%). In 13 out of 370 patients (3.6%), recurrences were observed and two were p53abn. When adjusting for median follow-up time, the odds ratio (OR) for recurrence among those with p53abn versus p53 wild type (p53wt) was 5.23-CI 95% 0.98-27.95, p = 0.053. The most common site of recurrence was the vaginal cuff (46.2%). One recurrence occurred within the first year of follow-up, and the patient exhibited p53abn. Both 1-year and 2-year DFS rates were 94.4% and 100% in the p53abn and p53wt groups, respectively. One patient died from the disease and comprised p53wt. No difference in OS was registered between the two groups; the median OS was 21.9 months (16.4-30.1). Larger multicenter studies are needed to tailor the treatment of low-risk EC patients with p53abn. Performing molecular classification on all EC patients might be cost-effective, and despite the limits of our relatively small sample, p53abn patients seem to be at greater risk of recurrence, especially locally and after two years since diagnosis

Characteristics and patterns of care of endometrial cancer before and during COVID-19 pandemic

Objective: Coronavirus disease 2019 (COVID-19) outbreak has correlated with the disruption of screening activities and diagnostic assessments. Endometrial cancer (EC) is one of the most common gynecological malignancies and it is often detected at an early stage, because it frequently produces symptoms. Here, we aim to investigate the impact of COVID-19 outbreak on patterns of presentation and treatment of EC patients. Methods: This is a retrospective study involving 54 centers in Italy. We evaluated patterns of presentation and treatment of EC patients before (period 1: March 1, 2019 to February 29, 2020) and during (period 2: April 1, 2020 to March 31, 2021) the COVID-19 outbreak. Results: Medical records of 5,164 EC patients have been retrieved: 2,718 and 2,446 women treated in period 1 and period 2, respectively. Surgery was the mainstay of treatment in both periods (p=0.356). Nodal assessment was omitted in 689 (27.3%) and 484 (21.2%) patients treated in period 1 and 2, respectively (p<0.001). While, the prevalence of patients undergoing sentinel node mapping (with or without backup lymphadenectomy) has increased during the COVID-19 pandemic (46.7% in period 1 vs. 52.8% in period 2; p<0.001). Overall, 1,280 (50.4%) and 1,021 (44.7%) patients had no adjuvant therapy in period 1 and 2, respectively (p<0.001). Adjuvant therapy use has increased during COVID-19 pandemic (p<0.001). Conclusion: Our data suggest that the COVID-19 pandemic had a significant impact on the characteristics and patterns of care of EC patients. These findings highlight the need to implement healthcare services during the pandemic

Practice patterns and 90-day treatment-related morbidity in early-stage cervical cancer

To evaluate the impact of the Laparoscopic Approach to Cervical Cancer (LACC) Trial on patterns of care and surgery-related morbidity in early-stage cervical cancer

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Abstract Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

Urban project, a matter of morphology

This research faces the theme of the actuality of the Urban Morphology discipline. Starting with the reconstruction of the history of urban studies in the schools of architecture in Italy in the last century, a personal approach to the theme is proposed as a result of an intense activity of academic cooperation of the authors (from the University of Naples Federico II) with the research group of Uwe Schröder (RWTH Aachen University in Germany). The main innovation, if referred to the Italian tradition, is that the city is now observed not only from the point of view of the ‘form’ but also considering the ‘space’: thus, the different qualities of the spaces that build every city and its wealth. The ‘results’ of this research are in the projects that the authors develop on different academic occasions; in fact, in Architecture, theory and practice are strictly connected. This is the reason why two projects are described at the end of the study in order to demonstrate that only a disciplinary knowledge of the city can produce its responsible modification, while more general ‘Conclusions’ define the innovation that the study proposes to the debate on Urban Morphology

Dal recinto alla radura. Il tema della villa in Mies van der Rohe

Il contributo indaga la ricerca di Mies van der Rohe sul tema della casa attraverso l’assunzione di un riconoscibile processo evolutivo che a partire dall’adozione del recinto come distintivo del luogo dell’abitare produce una progressiva apertura delle sue architetture domestiche verso la natura. Tale progressione – che è indagata attraverso il paradigma del recinto e del padiglione – è rinvenibile a partire dal padiglione di Barcellona e nella casa Tugendhat a Brno, passando per casa Hubbe, Lange e Caine, sino al compimento raggiunto in casa Farnsworth, preceduta dalla 50x50 feet house, nella quale sembra risuonare la Lichtung heideggeriana nell’istaurare un rinnovato rapporto con la natura assunta come materiale stesso della composizione

Ricerca e didattica

Il saggio prova a descrivere il complesso e articolato contributo didattico e formativo di Salvatore Bisogni, nel suo lungo insegnamento presso la Facoltà di Architettura di Napoli e nel suo rilevante contributo alla costruzione della scuola napoletana