Osmoregulation of chloride channels in epithelial cells

__Abstract__ The plasma membrane of mammalian cells is formed by two layers of lipids (lipid bilayer), primarily phospholipids, glycolipids and cholesterol, in which many different proteins are embedded. Phospholipid consists of a glycerol backbone esterified to fatty acids (the "lipid tail") and, via a phosphate group, to either choline, serine, inositol or ethanolamine (the "head group"). Whereas the head group is hydrophilic and oriented towards the outer surface of the membrane, the lipid tail is hydrophobic and pointed towards the inner part. The plasma membrane is impermeable to large molecules like carbohydrates and proteins but readily permeable to small uncharged molecules like oxygen, water, and carbon dioxide. Molecules can move through the membrane either by direct diffusion or through specialized channels or transport proteins (facilitated diffusion). In an isolated system, as stated by the Second Law of Thermodynamics, all events move spontaneously from a higher energy state to a lower energy state and are driven by the tendency to increase the entropy (degree for randomness/ disorder). When molecules are evenly distributed throughout the available space, the entropy is at its maximum. Therefore, free moving molecules and atoms (i.e. not part of a crystal structure and not restrained by additional forces) tend to distribute themselves over an as large as possible area. As a consequence of the Second Law of Thermodynamics, differences in the concentrations of non-permeable solutes between the cell and its surrounding medium will result in a redistribution of the solvent (e.g. water) to maintain the lowest energy possible, a phenomenon known as osmosis. Therefore, in response to an osmotic imbalance, water will move across a semi-permeable membrane until the water molecules are equally distributed, resulting in swelling or shrinkage. The Gibbs-Don nan effect refers to the observation that under certain conditions charged molecules or ions fail to distribute evenly across a semi-permeable membrane. At the Gibbs-Donnan equilibrium, the total number of positive charges balanced the total number of negative charges (bulk electroneutrality). Due to the presence of charged membrane-impermeable macromolecules and the electrogenic Na+ /K+ pump, however, the Gibbs Donnan equilibrium will never be obtained in an intact cell, leading to an asymmetric distribution of permeable ions and the generation of the membrane potential. A consequence of the presence of negatively charged membrane-impermeable proteins is the constant tendency of cells to accumulate water. To counteract a potential increase in volume, sodium is removed from the cells by the Na+ /K+ pump on the expenditure of metabolic energy. Because alterations in cell volume may affect many biochemical and physiological processes, almost all cell types have additional mechanisms to regulate their volume and to limit or prevent swelling and shrinkage

Entanglement preparation using symmetric multiports

We investigate the entanglement produced by a multi-path interferometer that is composed of two symmetric multiports, with phase shifts applied to the output of the first multiport. Particular attention is paid to the case when we have a single photon entering the interferometer. For this situation we derive a simple condition that characterize the types of entanglement that one can generate. We then show how one can use the results from the single photon case to determine what kinds of multi-photon entangled states one can prepare using the interferometer.Comment: 6 pages, 2 figures, accepted for publication in European Journal of Physics

Demonstration of large ionization coefficient ratio in AlAs0.56Sb0.44 lattice matched to InP

The electron and hole avalanche multiplication characteristics have been measured in bulk AlAs0.56Sb0.44 p-i-n and n-i-p homojunction diodes, lattice matched to InP, with nominal avalanche region thicknesses of ~0.6 μm, 1.0 μm and 1.5 μm. From these and data from two much thinner devices, the bulk electron and hole impact ionization coefficients (α and β respectively), have been determined over an electric-field range from 220-1250 kV/cm for α and from 360-1250 kV/cm for β for the first time. The α/β ratio is found to vary from 1000 to 2 over this field range, making it the first report of a wide band-gap III-V semiconductor with ionization coefficient ratios similar to or larger than that observed in silicon

KLEIN: A New Family of Lightweight Block Ciphers

Resource-efficient cryptographic primitives become fundamental for realizing both security and efficiency in embedded systems like RFID tags and sensor nodes. Among those primitives, lightweight block cipher plays a major role as a building block for security protocols. In this paper, we describe a new family of lightweight block ciphers named KLEIN, which is designed for resource-constrained devices such as wireless sensors and RFID tags. Compared to the related proposals, KLEIN has advantage in the software performance on legacy sensor platforms, while in the same time its hardware implementation can also be compact

Entanglement preparation using symmetric multiports

We investigate the entanglement produced by a multi-path interferometer that is composed of two symmetric multiports, with phase shifts applied to the output of the first multiport. Particular attention is paid to the case when we have a single photon entering the interferometer. For this situation we derive a simple condition that characterize the types of entanglement that one can generate. We then show how one can use the results from the single photon case to determine what kinds of multi-photon entangled states one can prepare using the interferometer.Comment: 6 pages, 2 figures, accepted for publication in European Journal of Physics

B_c meson rare decays in the light-cone quark model

We investigate the rare decays $B_c \rightarrow D_s(1968) \ell \bar{\ell}$ and $B_c\rightarrow D_s^*(2317) \ell \bar{\ell}$ in the framework of the light-cone quark model (LCQM). The transition form factors are calculated in the space-like region and then analytically continued to the time-like region via exponential parametrization. The branching ratios and longitudinal lepton polarization asymmetries (LPAs) for the two decays are given and compared with each other. The results are helpful to investigating the structure of $B_c$ meson and to testing the unitarity of CKM quark mixing matrix. All these results can be tested in the future experiments at the LHC.Comment: 9 pages, 11 figures, version accepted for publication in EPJ

Fast multi-computations with integer similarity strategy

Abstract. Multi-computations in finite groups, such as multiexponentiations and multi-scalar multiplications, are very important in ElGamallike public key cryptosystems. Algorithms to improve multi-computations can be classified into two main categories: precomputing methods and recoding methods. The first one uses a table to store the precomputed values, and the second one finds a better binary signed-digit (BSD) representation. In this article, we propose a new integer similarity strategy for multi-computations. The proposed strategy can aid with precomputing methods or recoding methods to further improve the performance of multi-computations. Based on the integer similarity strategy, we propose two efficient algorithms to improve the performance for BSD sparse forms. The performance factor can be improved from 1.556 to 1.444 and to 1.407, respectively

Lepton polarization correlations in B→K∗τ−τ+B \to K^* \tau^- \tau^+

In this work we will study the polarizations of both leptons ($\tau$) in the decay channel $B\to K^* \tau^- \tau^+$. In the case of the dileptonic inclusive decay $B\to K^* \ell^- \ell^+$, where apart from the polarization asymmetries of single lepton $\ell$, one can also observe the polarization asymmetries of both leptons simultaneously. If this sort of measurement is possible then we can have, apart from decay rate, FB asymmetry and the six single lepton polarization asymmetries (three each for $\ell^-$ and $\ell^+$), nine more double polarization asymmetries. This will give us a very useful tool in more strict testing of SM and the physics beyond. We discuss the double polarization asymmetries of $\tau$ leptons in the decay mode $B\to K^* \tau^- \tau^+$ within the SM and the Minimal Supersymmetric extensions of it.Comment: 21 pages, 21 figures; version to match paper to appear in PR

B_s --> mu+ mu- decay in the R-parity violating minimal supergravity

We study B_s --> mu+ mu- in the context of the R-parity violating minimal supergravity in the high tan beta regime. We find that the lowest value of the branching ratio can go well below the present LHCb sensitivity and hence B_s --> mu+ mu- can even be invisible to the LHC. We also find that the present upper bound on Br(B_s --> mu+ mu-) puts strong constraint on the minimal supergravity parameter space. The constraints become more severe if the upper bound is close to its standard model prediction.Comment: 18 pages, 10 figures; version to be published in European Physical Journal