5,584 research outputs found

    Scalar radiation from Chameleon-shielded regions

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    I study the profile of the Chameleon field around a radially pulsating mass. Focusing on the case in which the background (static) Chameleon profile exhibits a thin-shell, I add small perturbations to the source in the form of time-dependent radial pulsations. It is found that the Chameleon field inherits a time-dependence, there is a resultant scalar radiation from the region of the source and the metric outside the spherically symmetric mass is not static. This has several interesting and potentially testable consequences.Comment: 4 pages, 4 figures, slightly edited version matching the journal versio

    Parent and self-report health-related quality of life measures in young patients with Tourette syndrome

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    Tourette syndrome is a neurodevelopmental disorder characterized by tics and comorbid behavioral problems. This study compared child- and parent-reported quality of life and everyday functioning. We assessed 75 children with Tourette syndrome, of which 42 (56%) had comorbid conditions (obsessive-compulsive disorder = 25; attention-deficit hyperactivity disorder = 6; both comorbidities = 4). All patients completed psychometric instruments, including the Gilles de la Tourette Syndrome-Quality of Life Scale for Children and Adolescents (child report) and the Child Tourette's Syndrome Impairment Scale (parent report). Data were compared for patients with pure Tourette syndrome, Tourette syndrome + obsessive-compulsive disorder, Tourette syndrome + attention-deficit hyperactivity disorder, and Tourette syndrome + both comorbidities. There were no group differences in quality of life. However, there were differences for total, school, and home activities impairment scores. Children and parents may not share similar views about the impact of Tourette syndrome on functioning. The measurement of health-related quality of life in Tourette syndrome is more complex in children than adults

    Consecutive Case Series of Melanoma Sentinel Node Biopsy for Lymphoseek Compared to Sulfur Colloids

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    Introduction: Sentinel lymph node biopsy (SLNB) is an important adjunct in the staging of patients with melanoma. Preoperative lymphoscintigraphy (LS) with radiolabeled isotopes is essential to localize sentinel nodes for removal. Our study compared the effectiveness of Lymphoseek to standard sulfur colloids (SC) in patients with melanoma undergoing SLNB. Methods: We queried our IRB-approved melanoma database to identify 370 consecutive patients who underwent SLNB from 2012-2016 with at least one year of follow up. There were 185 patients in each group. Data points included characteristics of the primary melanoma lymphoscintigraphy, and SLNB. Student’s t-test and Chi-Square were used to analyze the data with a p-value of \u3c0.05 being considered significant. Results: Patients were equally matched in regard to age, sex, and primary characteristics of their melanoma. In comparison to SC, Lymphoseek required lower radiation dosages (p\u3c0.001), shorter mapping times (p=0.008), and decreased number of sentinel nodes removed (p=0.03). There was no difference in the number of patients with positive nodes (p=0.5). Additionally, there were no statistical differences between the two radioactive tracers in regard to the number of patients with false negative SLNB. Conclusion: Lymphoseek has the potential to decrease radioactivity and mapping time in patients who need SLNB. With a decrease in the number of nodes removed without loss of sensitivity, there is a potential to avoid unnecessary node removal and thus complications such as lymphedema. Longer follow-up will help to determine if there is any increase in false negative rates despite fewer nodes removed

    A 22-Week-Old Fetus with Nager Syndrome and Congenital Diaphragmatic Hernia due to a Novel SF3B4 Mutation.

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    Nager syndrome, or acrofacial dysostosis type 1 (AFD1), is a rare multiple malformation syndrome characterized by hypoplasia of first and second branchial arches derivatives and appendicular anomalies with variable involvement of the radial/axial ray. In 2012, AFD1 has been associated with dominant mutations in SF3B4. We report a 22-week-old fetus with AFD1 associated with diaphragmatic hernia due to a previously unreported SF3B4 mutation (c.35-2A>G). Defective diaphragmatic development is a rare manifestation in AFD1 as it is described in only 2 previous cases, with molecular confirmation in 1 of them. Our molecular finding adds a novel pathogenic splicing variant to the SF3B4 mutational spectrum and contributes to defining its prenatal/fetal phenotype

    Near real-time routine for volcano monitoring using infrared satellite data

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    An Advanced Very-High-Resolution Radiometer (AVHRR) routine for hotspot detection and effusion rate estimation (AVHotRR) using AVHRR infrared space-borne images is presented here for the monitoring of active lava flow. AVHotRR uses directly broadcast National Oceanic and Atmospheric Administration (NOAA)-AVHRR remotely sensed data. The 2006 summit eruption of Mount Etna provided the opportunity to test the products generated by AVHotRR for monitoring purposes. Low spatial and high temporal resolution products can also be used as inputs of flow models to drive numerical simulations of lava-flow paths and thus to provide quantitative hazard assessment and volcanic risk mitigation

    Inhibition of dengue virus replication by novel inhibitors of RNA-dependent RNA polymerase and protease activities

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    Dengue virus (DENV) is the leading mosquito-transmitted viral infection in the world. With more than 390 million new infections annually, and up to 1 million clinical cases with severe disease manifestations, there continues to be a need to develop new antiviral agents against dengue infection. In addition, there is no approved anti-DENV agents for treating DENV-infected patients. In the present study, we identified new compounds with anti-DENV replication activity by targeting viral replication enzymes – NS5, RNA-dependent RNA polymerase (RdRp) and NS3 protease, using cell-based reporter assay. Subsequently, we performed an enzyme-based assay to clarify the action of these compounds against DENV RdRp or NS3 protease activity. Moreover, these compounds exhibited anti-DENV activity in vivo in the ICR-suckling DENV-infected mouse model. Combination drug treatment exhibited a synergistic inhibition of DENV replication. These results describe novel prototypical small anti-DENV molecules for further development through compound modification and provide potential antivirals for treating DENV infection and DENV-related diseases

    Probing modifications of General Relativity using current cosmological observations

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    We test General Relativity (GR) using current cosmological data: the cosmic microwave background (CMB) from WMAP5 (Komatsu et al. 2009), the integrated Sachs-Wolfe (ISW) effect from the cross-correlation of the CMB with six galaxy catalogs (Giannantonio et al. 2008), a compilation of supernovae Type Ia (SNe) including the latest SDSS SNe (Kessler et al. 2009), and part of the weak lensing (WL) data from CFHTLS (Fu et al. 2008, Kilbinger et al. 2009) that probe linear and mildly non-linear scales. We first test a model where the effective Newton's constant, mu, and the ratio of the two gravitational potentials, eta, transit from the GR value to another constant at late times; in this case, we find that standard GR is fully consistent with the combined data. The strongest constraint comes from the ISW effect which would arise from this gravitational transition; the observed ISW signal imposes a tight constraint on a combination of mu and eta that characterizes the lensing potential. Next, we consider four pixels in time and space for each function mu and eta, and perform a Principal Component Analysis (PCA) finding that seven of the resulting eight eigenmodes are consistent with GR within the errors. Only one eigenmode shows a 2-sigma deviation from the GR prediction, which is likely to be due to a systematic effect. However, the detection of such a deviation demonstrates the power of our time- and scale-dependent PCA methodology when combining observations of structure formation and expansion history to test GR.Comment: 14 pages, 10 figures. Minor modifications, version published by Phys. Rev.
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