Role of the particle's stepping cycle in an asymmetric exclusion process: A model of mRNA translation

Messenger RNA translation is often studied by means of statistical-mechanical models based on the Asymmetric Simple Exclusion Process (ASEP), which considers hopping particles (the ribosomes) on a lattice (the polynucleotide chain). In this work we extend this class of models and consider the two fundamental steps of the ribosome's biochemical cycle following a coarse-grained perspective. In order to achieve a better understanding of the underlying biological processes and compare the theoretical predictions with experimental results, we provide a description lying between the minimal ASEP-like models and the more detailed models, which are analytically hard to treat. We use a mean-field approach to study the dynamics of particles associated with an internal stepping cycle. In this framework it is possible to characterize analytically different phases of the system (high density, low density or maximal current phase). Crucially, we show that the transitions between these different phases occur at different parameter values than the equivalent transitions in a standard ASEP, indicating the importance of including the two fundamental steps of the ribosome's biochemical cycle into the model.Comment: 9 pages, 9 figure

Control of spin relaxation in semiconductor double quantum dots

We propose a scheme to manipulate the spin relaxation in vertically coupled semiconductor double quantum dots. Up to {\em twelve} orders of magnitude variation of the spin relaxation time can be achieved by a small gate voltage applied vertically on the double dot. Different effects such as the dot size, barrier height, inter-dot distance, and magnetic field on the spin relaxation are investigated in detail. The condition to achieve a large variation is discussed.Comment: 5 pages, 4 figures, to be published in PR

The accretion environment of Supergiant Fast X-ray Transients probed with XMM-Newton

Supergiant fast X-ray transients (SFXTs) are characterized by a remarkable variability in the X-ray domain, widely ascribed to the accretion from a clumpy stellar wind. In this paper we performed a systematic and homogeneous analysis of sufficiently bright X-ray flares from the SFXTs observed with XMM-Newton to probe spectral variations on timescales as short as a few hundred of seconds. Our ultimate goal is to investigate if SFXT flares and outbursts are triggered by the presence of clumps and eventually reveal whether strongly or mildly dense clumps are required. For all sources, we employ a technique developed by our group, making use of an adaptive rebinned hardness ratio to optimally select the time intervals for the spectral extraction. A total of twelve observations performed in the direction of five SFXTs are reported. We show that both strongly and mildly dense clumps can trigger these events. In the former case, the local absorption column density may increase by a factor of >>3, while in the latter case, the increase is only by a factor of 2-3 (or lower). Overall, there seems to be no obvious correlation between the dynamic ranges in the X-ray fluxes and absorption column densities in SFXTs, with an indication that lower densities are recorded at the highest fluxes. This can be explained by the presence of accretion inhibition mechanism(s). We propose a classification of the flares/outbursts from these sources to drive future observational investigations. We suggest that the difference between the classes of flares/outbursts is related to the fact that the mechanism(s) inhibiting accretion can be overcome more easily in some sources compared to others. We also investigate the possibility that different stellar wind structures, rather than clumps, could provide the means to temporarily overcome the inhibition of accretion in SFXTs.Comment: Accepted for publication on A&

Two years of monitoring Supergiant Fast X-ray Transients with Swift

We present two years of intense Swift monitoring of three SFXTs, IGR J16479-4514, XTE J1739-302, and IGR J17544-2619 (since October 2007). Out-of-outburst intensity-based X-ray (0.3-10keV) spectroscopy yields absorbed power laws with by hard photon indices (G~1-2). Their outburst broad-band (0.3-150 keV) spectra can be fit well with models typically used to describe the X-ray emission from accreting NSs in HMXBs. We assess how long each source spends in each state using a systematic monitoring with a sensitive instrument. These sources spend 3-5% of the total in bright outbursts. The most probable flux is 1-2E-11 erg cm^{-2} s^{-1} (2-10 keV, unabsorbed), corresponding to luminosities in the order of a few 10^{33} to 10^{34} erg s^{-1} (two orders of magnitude lower than the bright outbursts). The duty-cycle of inactivity is 19, 39, 55%, for IGR J16479-4514, XTE J1739-302, and IGR J17544-2619, respectively. We present a complete list of BAT on-board detections further confirming the continued activity of these sources. This demonstrates that true quiescence is a rare state, and that these transients accrete matter throughout their life at different rates. X-ray variability is observed at all timescales and intensities we can probe. Superimposed on the day-to-day variability is intra-day flaring which involves variations up to one order of magnitude that can occur down to timescales as short as ~1ks, and whichcan be explained by the accretion of single clumps composing the donor wind with masses M_cl~0.3-2x10^{19} g. (Abridged)Comment: Accepted for publication in MNRAS. 17 pages, 11 figures, 8 table

Chemical abundances in the nucleus of the Sagittarius dwarf spheroidal galaxy

We present Iron, Magnesium, Calcium, and Titanium abundances for 235 stars in the central region of the Sagittarius dwarf spheroidal galaxy (within 9.0 arcmin ~70 pc from the center) from medium-resolution Keck/DEIMOS spectra. All the considered stars belong to the massive globular cluster M54 or to the central nucleus of the galaxy (Sgr,N). In particular we provide abundances for 109 stars with [Fe/H] > -1.0, more than doubling the available sample of spectroscopic metallicity and alpha-elements abundance estimates for Sgr dSph stars in this metallicity regime. Also, we find the first confirmed member of the Sagittarius dwarf spheroidal with [Fe/H]< -2.0 based on analysis of iron lines. We find for the first time a metallicity gradient in the Sgr,N population, whose peak iron abundance goes from [Fe/H]=-0.38 for R < 2.5 arcmin to [Fe/H]=-0.57 for 5.0 < R < 9.0 arcmin. On the other hand the trends of [Mg/Fe], [Ca/Fe], and [Ti/Fe] with [Fe/H] are the same over the entire region explored by our study. We reproduce the observed chemical patterns of the Sagittarius dwarf spheroidal as a whole with a chemical evolution model implying a high mass progenitor ( M_(DM)=6 X 10^{10} Msun ) and a significant event of mass-stripping occurred a few Gyr ago, presumably starting at the first peri-Galactic passage after infall.Comment: Accepted for publication to A&A, 12 pages, 14 figures, 1 tabl

Structure and in vitro digestibility of grass pea (Lathyrus sativus L.) flour following transglutaminase treatment

The impact of transglutaminase (TG) modification on microstructure and in vitro protein and starch digestibility of grass pea flour was investigated. Results demonstrated that grass pea flour proteins act as effective substrate of TG. Microstructural results showed that the addition of TG produced a more compact structure likely due to TG-catalyzed heteropolymers. Nutritional properties such as slowly digestible starch and expected glycemic index values followed the order: grass pea flour incubated in the absence of TG>grass pea flour incubated in the presence of TG>raw flour. The TG-catalyzed heteropolymers were easily digested as demonstrated by in vitro oral and gastric digestion carried out under physiological conditions. Therefore, TG-modified grass pea flour can be considered as a new source of starch and proteins suitable for feeding a large spectrum of population

XMM-Newton and Swift observations of XTE J1743-363

XTEJ1743-363 is a poorly known hard X-ray transient, that displays short and intense flares similar to those observed from Supergiant Fast X-ray Transients. The probable optical counterpart shows spectral properties similar to those of an M8 III giant, thus suggesting that XTEJ1743-363 belongs to the class of the Symbiotic X-ray Binaries. In this paper we report on the first dedicated monitoring campaign of the source in the soft X-ray range with XMM-Newton and Swift/XRT. T hese observations confirmed the association of XTEJ1743-363 with the previously suggested M8 III giant and the classification of the source as a member of the Symbiotic X-ray binaries. In the soft X-ray domain, XTEJ1743-363 displays a high absorption (~6x10^22 cm^-2 ) and variability on time scales of hundreds to few thousand seconds, typical of wind accreting systems. A relatively faint flare (peak X-ray flux 3x10^-11 erg/cm^2/s) lasting ~4 ks is recorded during the XMM-Newton observation and interpreted in terms of the wind accretion scenario.Comment: Accepted for publication on A&

Approximate analytical description of the nonaffine response of amorphous solids

An approximation scheme for model disordered solids is proposed that leads to the fully analytical evaluation of the elastic constants under explicit account of the inhomogeneity (nonaffinity) of the atomic displacements. The theory is in quantitative agreement with simulations for central-force systems and predicts the vanishing of the shear modulus at the isostatic point with the linear law {\mu} ~ (z - 2d), where z is the coordination number. The vanishing of rigidity at the isostatic point is shown to be a consequence of the canceling out of positive affine and negative nonaffine terms