173 research outputs found
A Spinning Anti-de Sitter Wormhole
We construct a 2+1 dimensional spacetime of constant curvature whose spatial
topology is that of a torus with one asymptotic region attached. It is also a
black hole whose event horizon spins with respect to infinity. An observer
entering the hole necessarily ends up at a "singularity"; there are no inner
horizons.
In the construction we take the quotient of 2+1 dimensional anti-de Sitter
space by a discrete group Gamma. A key part of the analysis proceeds by
studying the action of Gamma on the boundary of the spacetime.Comment: Latex, 28 pages, 7 postscript figures included in text, a Latex file
without figures can be found at http://vanosf.physto.se/~stefan/spinning.html
Replaced with journal version, minor change
On the Equivalence Between Type I Liouville Dynamical Systems in the Plane and the Sphere
ProducciĂłn CientĂficaSeparable Hamiltonian systems either in sphero-conical coordinates on an S2 sphere or in elliptic coordinates on a R2 plane are described in a unified way. A back and forth route connecting these Liouville Type I separable systems is unveiled. It is shown how the gnomonic projection and its inverse map allow us to pass from a Liouville Type I separable system with a spherical configuration space
to its Liouville Type I partners where the configuration space is a plane and back. Several selected spherical separable systems and their planar cousins are discussed in a classical context
Intraperitoneal bevacizumab for control of malignant ascites due to advanced-stage gastrointestinal cancers: A multicentre double-blind, placebo-controlled phase II study - AIO SUP-0108
PURPOSE:
Malignant ascites is debilitating for patients with advanced cancer. As shown previously, tumour cell production of vascular endothelial growth factor might be a major cause of the formation of malignant ascites. Intraperitoneal bevacizumab could therefore be an option for symptom control in refractory ascites.
PATIENTS AND METHODS:
Patients with advanced gastrointestinal cancer and malignant ascites who had undergone paracentesis at least twice within the past 4 weeks were randomly assigned in a 2:1 ratio to intraperitoneal bevacizumab (400 mg absolute) or placebo after paracentesis. During the 8-week treatment period, a minimum interval of 14 d was kept between the applications of the study drug. Primary end-point was paracentesis-free survival (ParFS).
RESULTS:
Fifty-three patients (median age 63 years) were randomised. Forty-nine patients received at least one study drug application and qualified for the main analysis. The proportion of patients with at least one common toxicity criteria grade III-V event was similar with 20/33 (61%) on bevacizumab and 11/16 (69%) on placebo. Median ParFS was 14 d (95% confidence interval [CI]: 11-17) in the bevacizumab arm and 10.5 d (95% CI: 7-21) on placebo (hazard ratio 0.74, 95% CI: 0.40-1.37; P = 0.16). The longest paracentesis-free period was 19 d on bevacizumab (range 6-66 d) and 17.5 d in the placebo arm (range 4-42) (P = 0.85). Median overall survival was 64 d (95% CI: 45-103) on bevacizumab compared to 31.5 d (95% CI: 20-117) on placebo (P = 0.31).
CONCLUSION:
Intraperitoneal bevacizumab was well tolerated. Overall, treatment did not result in a significantly better symptom control of malignant ascites. However, patients defined by specific immune characteristics may benefit
Nonintegrability of the two-body problem in constant curvature spaces
We consider the reduced two-body problem with the Newton and the oscillator
potentials on the sphere and the hyperbolic plane .
For both types of interaction we prove the nonexistence of an additional
meromorphic integral for the complexified dynamic systems.Comment: 20 pages, typos correcte
Two-body quantum mechanical problem on spheres
The quantum mechanical two-body problem with a central interaction on the
sphere is considered. Using recent results in representation
theory an ordinary differential equation for some energy levels is found. For
several interactive potentials these energy levels are calculated in explicit
form.Comment: 41 pages, no figures, typos corrected; appendix D was adde
Developmental malformation of the corpus callosum: a review of typical callosal development and examples of developmental disorders with callosal involvement
This review provides an overview of the involvement of the corpus callosum (CC) in a variety of developmental disorders that are currently defined exclusively by genetics, developmental insult, and/or behavior. I begin with a general review of CC development, connectivity, and function, followed by discussion of the research methods typically utilized to study the callosum. The bulk of the review concentrates on specific developmental disorders, beginning with agenesis of the corpus callosum (AgCC)—the only condition diagnosed exclusively by callosal anatomy. This is followed by a review of several genetic disorders that commonly result in social impairments and/or psychopathology similar to AgCC (neurofibromatosis-1, Turner syndrome, 22q11.2 deletion syndrome, Williams yndrome, and fragile X) and two forms of prenatal injury (premature birth, fetal alcohol syndrome) known to impact callosal development. Finally, I examine callosal involvement in several common developmental disorders defined exclusively by behavioral patterns (developmental language delay, dyslexia, attention-deficit hyperactive disorder, autism spectrum disorders, and Tourette syndrome)
Entry Mode Degree of Control, Firm Performance and Host Country Institutional Development: A Meta-Analysis
Among studies on performance outcomes of entry mode choices disagreement fueled by ambiguous research findings is apparent as regards whether the best per- formers are those firms that enter foreign countries with high or low entry mode degree of control. To solve this dilemma and test new hypotheses, the relationship between entry mode degree of control and firm performance is examined by meta- analyzing 133 studies (740,114 observations) covering entry mode choices from 1980 to 2010. We find that (a) overall high-control entry modes lead to higher per- formance, and (b) adopting high-control entry modes is particularly important for firms entering developing countries
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