Dependence of heat transport on the strength and shear rate of prescribed circulating flows

We study numerically the dependence of heat transport on the maximum velocity and shear rate of physical circulating flows, which are prescribed to have the key characteristics of the large-scale mean flow observed in turbulent convection. When the side-boundary thermal layer is thinner than the viscous boundary layer, the Nusselt number (Nu), which measures the heat transport, scales with the normalized shear rate to an exponent 1/3. On the other hand, when the side-boundary thermal layer is thicker, the dependence of Nu on the Peclet number, which measures the maximum velocity, or the normalized shear rate when the viscous boundary layer thickness is fixed, is generally not a power law. Scaling behavior is obtained only in an asymptotic regime. The relevance of our results to the problem of heat transport in turbulent convection is also discussed.Comment: 7 pages, 7 figures, submitted to European Physical Journal

Development of EHD Ion-Drag Micropump for Microscale Electronics Cooling Systems

In this investigation, the numerical simulation of electrohydrodynamic (EHD) ion-drag micropumps with micropillar electrode geometries have been performed. The effect of micropillar height and electrode spacing on the performance of the micropumps was investigated. The performance of the EHD micropump improved with increased applied voltage and decreased electrode spacing. The optimum micropillar height for the micropump with electrode spacing of 40$\mu$m and channel height of 100$\mu$m at 200V was 40$\mu$m, where a maximum mass flow rate of 0.18g/min was predicted. Compared to that of planar electrodes, the 3D micropillar electrode geometry enhanced the overall performance of the EHD micropumps.Comment: Submitted on behalf of TIMA Editions (http://irevues.inist.fr/tima-editions

Disorder in DNA-Linked Gold Nanoparticle Assemblies

We report experimental observations on the effect of disorder on the phase behavior of DNA-linked nanoparticle assemblies. Variation in DNA linker lengths results in different melting temperatures of the DNA-linked nanoparticle assemblies. We observed an unusual trend of a non-monotonic ``zigzag'' pattern in the melting temperature as a function of DNAlinker length. Linker DNA resulting in unequal DNA duplex lengths introduces disorder and lowers the melting temperature of the nanoparticle system. Comparison with free DNA thermodynamics shows that such an anomalous zigzag pattern does not exist for free DNA duplex melting, which suggests that the disorder introduced by unequal DNA duplex lengths results in this unusual collective behavior of DNA-linked nanoparticle assemblies.Comment: 4 pages, 4 figures, Phys.Rev.Lett. (2005), to appea

On Conditional Statistics in Scalar Turbulence: Theory vs. Experiment

We consider turbulent advection of a scalar field T(\B.r), passive or active, and focus on the statistics of gradient fields conditioned on scalar differences $\Delta T(R)$ across a scale $R$. In particular we focus on two conditional averages $\langle\nabla^2 T\big|\Delta T(R)\rangle$ and $\langle|\nabla T|^2\big|\Delta T(R) \rangle$. We find exact relations between these averages, and with the help of the fusion rules we propose a general representation for these objects in terms of the probability density function $P(\Delta T,R)$ of $\Delta T(R)$. These results offer a new way to analyze experimental data that is presented in this paper. The main question that we ask is whether the conditional average $\langle\nabla^2 T\big| \Delta T(R)\rangle$ is linear in $\Delta T$. We show that there exists a dimensionless parameter which governs the deviation from linearity. The data analysis indicates that this parameter is very small for passive scalar advection, and is generally a decreasing function of the Rayleigh number for the convection data.Comment: Phys. Rev. E, Submitted. REVTeX, 10 pages, 5 figs. (not included) PS Source of the paper with figure available at http://lvov.weizmann.ac.il/onlinelist.html#unpub

Rapamycin-induced autophagy aggravates pathology and weakness in a mouse model of VCP-associated myopathy

Pathological phenotypes in inclusion body myopathy (IBM) associated with Paget disease of the bone (PDB), frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) (IBMPFD/ALS) include defective autophagosome and endosome maturation that result in vacuolation, weakness and muscle atrophy. The link between autophagy and IBMPFD/ALS pathobiology has been poorly understood. We examined the AKT-FOXO3 and MTOR pathways to characterize the regulation of autophagy in IBMPFD/ALS mouse muscle. We identified a defect in MTOR signaling that results in enhanced autophagosome biogenesis. Modulating MTOR signaling may therefore be a viable therapeutic target in IBMPFD/ALS

High-Order Contamination in the Tail of Gravitational Collapse

It is well known that the late-time behaviour of gravitational collapse is {\it dominated} by an inverse power-law decaying tail. We calculate {\it higher-order corrections} to this power-law behaviour in a spherically symmetric gravitational collapse. The dominant ``contamination'' is shown to die off at late times as $M^2t^{-4}\ln(t/M)$. This decay rate is much {\it slower} than has been considered so far. It implies, for instance, that an `exact' (numerical) determination of the power index to within $\sim 1$ requires extremely long integration times of order $10^4 M$. We show that the leading order fingerprint of the black-hole electric {\it charge} is of order $Q^2t^{-4}$.Comment: 12 pages, 2 figure

Passive Scalar: Scaling Exponents and Realizability

An isotropic passive scalar field $T$ advected by a rapidly-varying velocity field is studied. The tail of the probability distribution $P(\theta,r)$ for the difference $\theta$ in $T$ across an inertial-range distance $r$ is found to be Gaussian. Scaling exponents of moments of $\theta$ increase as $\sqrt{n}$ or faster at large order $n$, if a mean dissipation conditioned on $\theta$ is a nondecreasing function of $|\theta|$. The $P(\theta,r)$ computed numerically under the so-called linear ansatz is found to be realizable. Some classes of gentle modifications of the linear ansatz are not realizable.Comment: Substantially revised to conform with published version. Revtex (4 pages) with 2 postscript figures. Send email to [email protected]