Pushing 1D CCSNe to explosions: model and SN 1987A

We report on a method, PUSH, for triggering core-collapse supernova explosions of massive stars in spherical symmetry. We explore basic explosion properties and calibrate PUSH such that the observables of SN1987A are reproduced. Our simulations are based on the general relativistic hydrodynamics code AGILE combined with the detailed neutrino transport scheme IDSA for electron neutrinos and ALS for the muon and tau neutrinos. To trigger explosions in the otherwise non-exploding simulations, we rely on the neutrino-driven mechanism. The PUSH method locally increases the energy deposition in the gain region through energy deposition by the heavy neutrino flavors. Our setup allows us to model the explosion for several seconds after core bounce. We explore the progenitor range 18-21M$_{\odot}$. Our studies reveal a distinction between high compactness (HC) and low compactness (LC) progenitor models, where LC models tend to explore earlier, with a lower explosion energy, and with a lower remnant mass. HC models are needed to obtain explosion energies around 1 Bethe, as observed for SN1987A. However, all the models with sufficiently high explosion energy overproduce $^{56}$Ni. We conclude that fallback is needed to reproduce the observed nucleosynthesis yields. The nucleosynthesis yields of $^{57-58}$Ni depend sensitively on the electron fraction and on the location of the mass cut with respect to the initial shell structure of the progenitor star. We identify a progenitor and a suitable set of PUSH parameters that fit the explosion properties of SN1987A when assuming 0.1M$_{\odot}$ of fallback. We predict a neutron star with a gravitational mass of 1.50M$_{\odot}$. We find correlations between explosion properties and the compactness of the progenitor model in the explored progenitors. However, a more complete analysis will require the exploration of a larger set of progenitors with PUSH.Comment: revised version as accepted by ApJ (results unchanged, text modified for clarification, a few references added); 26 pages, 20 figure

Seismicity of the central Afar rift and implications for Tendaho dam hazards

Temporary broadband seismic networks deployed from 2007 to 2011 around the Afar triple junction of the East African Rift System provide insights into seismicity patterns of the actively deforming crust around the 1.86 km3 impounded lake system behind the Tendaho dam. The observed seismicity correlates well with the active magmatic centres around central Afar. The area around the dam site is characterized by a network of intersecting NNE- and NW-trending faults. Seismicity clusters observed in the specified time interval indicate that both fault sets are active and are potential sources of seismogenic hazards. The dam neighbourhood is naturally active and it is a challenge to associate the observed seismic activity to either a change in magmato-tectonic conditions or attribute it to the influence of reservoir load. It is evident that the dam region experi- ences high levels of seismic and volcano-tectonic unrest, regardless of the origin of the activity. The spatial overlap of narrow zones of crustal seismicity and upper mantle low velocity zones observed in S-wave tomography models suggests that melt production zones guide the distribution of strain during continental rupture. Given its volcanically and seismically active setting, the Tendaho dam site and the surrounding region require continuous monitoring for the safety of downstream popu- lations and development infrastructures in the Afar National Regional State of Ethiopia

Local Biological Reactions and Pseudotumor-Like Tissue Formation in relation to Metal Wear in a Murine In Vivo Model

Metal wear debris and released ions (CoCrMo), which are widely generated in metal-on-metal bearings of hip implants, are also found in patients with metal-on-polyethylene bearings due to the mechanically assisted crevice corrosion of modular taper junctions, including head-neck and neck-stem taper interfaces. The resulting adverse reactions to metal debris and metal ions frequently lead to early arthroplasty revision surgery. National guidelines have since been published where the blood metal ion concentration of patients must consistently be monitored after joint replacement to prevent serious complications from developing after surgery. However, to date, the effect of metal particles and metal ions on local biological reactions is complex and still not understood in detail;the present study sought to elucidate the complex mechanism of metal wear-associated inflammation reactions. The knee joints in 4 groups each consisting of 10 female BALB/c mice received injections with cobalt chrome ions, cobalt chrome particles, and ultra-high-molecular-weight polyethylene (UHMWPE) particles or PBS (control). Seven days after injection, the synovial microcirculation and knee joint diameter were assessed via intravital fluorescence microscopy followed by histological evaluation of the synovial layer. Enlarged knee diameter, enhanced leukocyte to endothelial cell interactions, and an increase in functional capillary density within cobalt chrome particle-treated animals were significantly greater than those in the other treatment groups. Subsequently, pseudotumor-like tissue formations were observed only in the synovial tissue layer of the cobalt chrome particle-treated animals. Therefore, these findings strongly suggest that the cobalt chrome particles and not metal ions are the cause for in vivo postsurgery implantation inflammation

Density Dependence, Whitebark Pine Decline and Vital Rates of Grizzly Bears in The Greater Yellowstone Ecosystem

Recent evidence suggests annual population growth of the grizzly bear (Ursus arctos) population in the Greater Yellowstone Ecosystem has slowed from 4.1–7.6 percent during 1983–2001 to 0.3–2.2 percent during 2002–2011. Substantial changes in availability of an important fall food has occurred over the past decade. Whitebark pine (Pinus albicaulis), a highly variable but important fall food source for grizzly bears, has experienced substantial mortality due to a mountain pine beetle (Dendroctonus ponderosae) outbreak that started in the early 2000s. Concurrent with changes in food resources, the grizzly bear population has reached high densities in some areas and has continued to expand, now occupying >50,000 km2. We tested research hypotheses to examine if changes in vital rates detected during the past decade were more associated with grizzly bear density versus a whitebark pine decline. We focused our assessment on known-fate data to estimate survival of cubs-of-the-year, yearlings, and independent bears (? 2 yrs) and reproductive transition of females from having no offspring to having cubs.  We observed a change in survival of independent bears between the periods of 1983–2001 and 2002–2012, which was mostly a function of increased male survival; female survival did not change. Cub survival and reproductive transition declined during the last decade and were associated with an index of grizzly bear density, which indicated increasing density over time. We found no support that the decline in these vital rates was associated with the index of whitebark decline

B-cell populations discriminate between pediatric- and adult-onset multiple sclerosis

Objective: To comparatively assess the B-cell composition in blood and CSF of patients with pediatric-onset multiple sclerosis (pedMS) and adult-onset multiple sclerosis (adMS). / Methods: In this cross-sectional study, we obtained blood and CSF samples from 25 patients with pedMS (8–18 years) and 40 patients with adMS (23–65 years) and blood specimens from 66 controls (1–55 years). By using multicolor flow cytometry, we identified naive, transitional, isotype class-switched memory, nonswitched memory, and double-negative memory B-cell subsets as well as plasmablasts (PB) and terminally differentiated plasma cells (PC). Flow cytometric data were compared to concentrations of B-cell-specific cytokines in serum and CSF as determined by ELISA. / Results: Frequencies of circulating naive B-cells decreased with higher age in controls but not in patients with multiple sclerosis (MS). B-cell patterns in CSF differed between pedMS and adMS with an acute relapse: in pedMS-derived CSF samples, high frequencies of nonswitched memory B cells and PB were present, whereas class-switched memory B cells and PC dominated in the CSF of patients with adMS. In pedMS, PB were also elevated in the periphery. Accumulation of PB in the CSF correlated with high intrathecal CXCL-13 levels and augmented intrathecal synthesis of immunoglobulin G and immunoglobulin M. / Conclusions: We demonstrate distinct changes in intrathecal B-cell homeostasis in patients with pedMS during active disease, which differ from those in adults by an expansion of plasmablasts in blood and CSF and similarly occur in prototypic autoantibody-driven autoimmune disorders. This emphasizes the particular importance of activated B-lymphocyte subsets for disease progression in the earliest clinical stages of MS

Surface-wave imaging of the weakly-extended Malawi Rift from ambient-noise and teleseismic Rayleigh waves from onshore and lake-bottom seismometers

Located at the southernmost sector of the Western Branch of the East African Rift System, the Malawi Rift exemplifies an active, magma-poor, weakly extended continental rift. To investigate the controls on rifting, we image crustal and uppermost mantle structure beneath the region using ambient-noise and teleseismic Rayleigh-wave phase velocities between 9 and 100 s period. Our study includes six lake-bottom seismometers located in Lake Malawi (Nyasa), the first time seismometers have been deployed in any of the African rift lakes. Noise-levels in the lake are lower than that of shallow oceanic environments and allow successful application of compliance corrections and instrument orientation determination. Resulting phase-velocity maps reveal slow velocities primarily confined to Lake Malawi at short periods (T 25 s) a prominent low-velocity anomaly exists beneath the Rungwe Volcanic Province at the northern terminus of the rift basin. Estimates of phase-velocity sensitivity indicates these low velocities occur within the lithospheric mantle and potentially uppermost asthenosphere, suggesting that mantle processes may control the association of volcanic centers and the localization of magmatism. Beneath the main portion of the Malawi Rift, a modest reduction in velocity is also observed at periods sensitive to the crust and upper mantle, but these velocities are much higher than those observed beneath Rungwe

Biallelic PDX1 (insulin promoter factor 1) mutations causing neonatal diabetes without exocrine pancreatic insufficiency

This is the final version. Available on open access from Wiley via the DOI in this recordAims: Recessive PDX1 (IPF1) mutations are a rare cause of pancreatic agenesis, with three cases reported worldwide. A recent report described two cousins with a homozygous hypomorphic PDX1 mutation causing permanent neonatal diabetes with subclinical exocrine insufficiency. The aim of our study was to investigate the possibility of hypomorphic PDX1 mutations in a large cohort of patients with permanent neonatal diabetes and no reported pancreatic hypoplasia or exocrine insufficiency. Methods: PDX1 was sequenced in 103 probands with isolated permanent neonatal diabetes in whom ABCC8, KCNJ11 and INS mutations had been excluded. Results: Sequencing analysis identified biallelic PDX1 mutations in three of the 103 probands with permanent neonatal diabetes (2.9%). One proband and his affected brother were compound heterozygotes for a frameshift and a novel missense mutation (p.A34fsX191; c.98dupC and p.P87L; c.260C>T). The other two probands were homozygous for novel PDX1 missense mutations (p.A152G; c.455C>G and p.R176Q; c.527G>A). Both mutations affect highly conserved residues located within the homeobox domain. None of the four cases showed any evidence of exocrine pancreatic insufficiency, either clinically, or, where data were available, biochemically. In addition a heterozygous nonsense mutation (p.C18X; c.54C>A) was identified in a fourth case. Conclusions: This study demonstrates that recessive PDX1 mutations are a rare but important cause of isolated permanent neonatal diabetes in patients without pancreatic hypoplasia/agenesis. Inclusion of the PDX1 gene in mutation screening for permanent neonatal diabetes is recommended as a genetic diagnosis reveals the mode of inheritance, allows accurate estimation of recurrence risks and confirms the requirement for insulin treatment. © 2013 The Authors. Diabetic Medicine © 2013 Diabetes UK.Diabetes UKEuropean Union FP