Increased D-dimer value and occult cancer in the absence of detectable thrombosis.

Fibrin formation and removal occurs continuously during the development of malignancy. Accordingly, hemostatic disorders in cancer patients are a rather frequent observation and range from asymptomatic laboratory changes to massive thromboembolism or haemorrhage. We document the case of an asymptomatic women, who was enrolled as a healthy control in a study and showed up with a substantially increased D- dimer value. After ruling out the most probable sources of D-dimer elevation, such as thrombosis, inflammation and trauma, she underwent laboratory and radiological investigations for malignancy, which were consistent with a colorectal metastatic adenocarcinoma. This case allow us to hypothesize that screening for occult malignancy in the presence of apparently inexplicable elevated D-dimer values may be taken into consideration

Boson-conserving one-nucleon transfer operator in the interacting boson model

The boson-conserving one-nucleon transfer operator in the interacting boson model (IBA) is reanalyzed. Extra terms are added to the usual form used for that operator. These new terms change generalized seniority by one unit, as the ones considered up to now. The results obtained using the new form for the transfer operator are compared with those obtained with the traditional form in a simple case involving the pseudo-spin Bose-Fermi symmetry $U^{B}(6) \otimes U^F(12)$ in its $U^{BF}(5) \otimes U^F(2)$ limit. Sizeable differences are found. These results are of relevance in the study of transfer reactions to check nuclear supersymmetry and in the description of (\beta)-decay within IBA.Comment: 13 pages, 1 table, 0 figures. To be published in Phys. Rev.

Two-nucleon emission in the longitudinal response

The contribution of the two-nucleon emission in the longitudinal response for inclusive electron scattering reactions is studied. The model adopted to perform the calculations is based upon Correlated Basis Function theory but it considers only first order terms in the correlation function. The proper normalization of the wave function is ensured by considering, in addition to the usually evaluated two-point diagrams, also the three-point diagrams. Results for the 12C nucleus in the quasi-elastic region are presented.Comment: 7 pages, 4 Postscript figure

Correlation effects in single-particle overlap functions and one-nucleon removal reactions

Single-particle overlap functions and spectroscopic factors are calculated on the basis of the one-body density matrices (ODM) obtained for the nucleus $^{16}O$ employing different approaches to account for the effects of correlations. The calculations use the relationship between the overlap functions related to bound states of the (A-1)-particle system and the ODM for the ground state of the A-particle system. The resulting bound-state overlap functions are compared and tested in the description of the experimental data from (p,d) reactions for which the shape of the overlap function is important.Comment: 11 pages, 4 figures include

One Body Density Matrix, Natural Orbits and Quasi Hole States in 16O and 40Ca

The one body density matrix, momentum distribution, natural orbits and quasi hole states of 16O and 40Ca are analyzed in the framework of the correlated basis function theory using state dependent correlations with central and tensor components. Fermi hypernetted chain integral equations and single operator chain approximation are employed to sum cluster diagrams at all orders. The optimal trial wave function is determined by means of the variational principle and the realistic Argonne v8' two-nucleon and Urbana IX three-nucleon interactions. The correlated momentum distributions are in good agreement with the available variational Monte Carlo results and show the well known enhancement at large momentum values with respect to the independent particle model. Diagonalization of the density matrix provides the natural orbits and their occupation numbers. Correlations deplete the occupation number of the first natural orbitals by more than 10%. The first following ones result instead occupied by a few percent. Jastrow correlations lower the spectroscopic factors of the valence states by a few percent (~1-3%) and an additional ~8-12% depletion is provided by tensor correlations. It is confirmed that short range correlations do not explain the spectroscopic factors extracted from (e,e'p) experiments. 2h-1p perturbative corrections in the correlated basis are expected to provide most of the remaining strength, as in nuclear matter.Comment: 25 pages, 9 figures. Submitted to Phys.Rev.

Fluorescent Labeling of SNAP-Tagged Proteins in Cells

One of the most prominent self-labeling tags is SNAP-tag. It is an in vitro evolution product of the human DNA repair protein O6 -alkylguanine-DNA alkyltransferase (hAGT) that reacts specifically with benzylguanine (BG) and benzylchloropyrimidine (CP) derivatives, leading to covalent labeling of SNAP-tag with a synthetic probe (Gronemeyer et al., Protein Eng Des Sel 19:309–316, 2006; Curr Opin Biotechnol 16:453–458, 2005; Keppler et al., Nat Biotechnol 21:86–89, 2003; Proc Natl Acad Sci U S A 101:9955– 9959, 2004). SNAP-tag is well suited for the analysis and quantification of fused target protein using fluorescence microscopy techniques. It provides a simple, robust, and versatile approach to the imaging of fusion proteins under a wide range of experimental conditions. © Springer Science+Business Media New York 2015

Will reducing border barriers via the EU's b-solutions lead towards greater European territorial integration?

Despite the positive contributions of several European Union (EU) policies to reduce border barriers, the EU Cross-Border Review (CBR) initiative reaffirmed their relevance and persistence. Since 2018, the EU has supported the b-solutions initiative, specifically focused on tackling legal and administrative border obstacles, aiming to highlight replicable solutions which can contribute to reducing these obstacles. This article critically assesses the b-solutions and its contribution to reducing administrative and legal border obstacles, with an eye to promoting a more integrated European territory. It is concluded that b-solutions is a valid, yet insufficient, initiative to provide replicable solutions to mitigate cross-border barriers.info:eu-repo/semantics/acceptedVersio

Reducing border barriers for cross-border commuters in Europe via the EU b-solutions initiative

For more than six decades, the European Union (EU) has promoted, one way or the other, systematic European territorial integration, understood as the process of reducing many kinds of cross-border barriers. This article debates the role of the EU b-solutions initiative in facilitating cross-border commuting in Europe via its contribution to a body of knowledge, which, in its practical application, has the potential to act as a resource to be drawn on in the mitigation of a wide range of legal-administrative barriers. A theoretical framework for relating cross-border commuting and cross-border barriers is set out, and existing cases from the b-solutions initiative are mapped against it. The authors demonstrate the framework’s value as a tool for determining the relevance of cross-border obstacles and solution factors for the issue of cross-border commuting. The paper concludes that the EU b-solutions contributed with concrete policy actions as well as a body of knowledge and solution-orientated planning towards reducing a range of legal-administrative cross-border barriers in Europe, and therefore represents a set of lebenswelt interventions contributing to the potential for increasing cross-border commuting flows.info:eu-repo/semantics/acceptedVersio

Direct measurement of diffusing proteins in nanochannels using fluorescence correlation spectroscopy

Transport of proteins in liquid-filled nanometer-sized apertures with charged surfaces based on both diffusion and convective flow is investigated with the use of fluorescence correlation spectroscopy. The measured fluctuations of fluorescence allow the evaluation of the concentration of molecules directly inside the nanochannel. Here, we supply theoretical models describing the concentration profile of proteins inside nano-confinements, taking into account the steric exclusion, the presence of reversibly adsorbed molecules on surfaces and the exclusion-enrichment effect due to interaction with the electrical double layer. Therefore, this study presents a new step for a deeper understanding of the transport of molecules in nanofluidics