Cuando la nación queda lejos fronteras cotidianas en el paso Lago Verde (Aysén-chile) - Aldea Las Pampas (Chubut-Argentina)

Se busca reflexionar en torno a los procesos de colonialidad con que la nación va fijando el sentido de los espacios fronterizos y en cómo, en forma paralela y en diálogo a esa narración de escala nacional se desenvuelve un mundo cotidiano que muchas veces queda lejos de lo que es p royectado por la nación para esas particulares zonas. A través del caso de la zona fronteriza de Lago Verde-Las Pampas (Chile-Argentina) y de la presencia de una familia que ocupa desde “antes de la nación” toda el área fronteriza, ponemos en consideración “el despliegue de la experiencia del habitar”, es decir, aquella “histo- ricidad existencial” de los lugares o “estructura de la experiencia del territorio” que, en el fondo, restituye y p royecta una realidad intervenida por la memoria, por el arraigo a partir de aquella co-fabricación o co-pertenencia entre el sujeto y el paisaje que él mismo construye, al tiempo que lo habita (es decir, lo autoconstruye).This paper looks to reflect on the colonialist processes through which the nation determines a sense of its border spaces and how, at the same time and in dialogue with this national narrative, the everyday world of these border zones develops in ways that are often very diff erent from what is projected by the nation. Through the case study of one border zone, that of Lake Verde-Las Pampas (Chile-Argentina), and the presence of a family that has occupied the entire border area from “before the nation”, we consider evidence of the experience of living, or in other words, the existential historicity of place or the structure of territorial experience that, in essence, restores and projects a reality marked by memory; by roots based on co-production or co-belonging between the subject and the landscape that is constructed at the same time as it is inhabited (i.e. the landscape as self-constructed).Fil: Nuñez, Andres. Pontificia Universidad Católica de Chile; ChileFil: Baeza, Brigida Norma. Universidad Nacional de la Patagonia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Benwell, Matthew C.. Newcastle University; Reino Unid

Compliance to radiation therapy of head and neck cancer patients and impact on treatment outcome

The aims of the study were to evaluate head and neck cancer (HNC) patient's compliance to the planned radiation therapy (RT) using the department policy established in 2005 at IPOCFG and to estimate the impact on treatment outcome due to failure in receiving RT as prescribed.info:eu-repo/semantics/publishedVersio

Radiobiological evaluation of forward and inverse IMRT using different fractionations for head and neck tumours

<p>Abstract</p> <p>Purpose</p> <p>To quantify the radiobiological advantages obtained by an Improved Forward Planning technique (IFP) and two IMRT techniques using different fractionation schemes for the irradiation of head and neck tumours. The conventional radiation therapy technique (CONVT) was used here as a benchmark.</p> <p>Methods</p> <p>Seven patients with head and neck tumours were selected for this retrospective planning study. The PTV1 included the primary tumour, PTV2 the high risk lymph nodes and PTV3 the low risk lymph nodes. Except for the conventional technique where a maximum dose of 64.8 Gy was prescribed to the PTV1, 70.2 Gy, 59.4 Gy and 50.4 Gy were prescribed respectively to PTV1, PTV2 and PTV3. Except for IMRT2, all techniques were delivered by three sequential phases. The IFP technique used five to seven directions with a total of 15 to 21 beams. The IMRT techniques used five to nine directions and around 80 segments. The first, IMRT1, was prescribed with the conventional fractionation scheme of 1.8 Gy per fraction delivered in 39 fractions by three treatment phases. The second, IMRT2, simultaneously irradiated the PTV2 and PTV3 with 59.4 Gy and 50.4 Gy in 28 fractions, respectively, while the PTV1 was boosted with six subsequent fractions of 1.8 Gy. Tissue response was calculated using the relative seriality model and the Poisson Linear-Quadratic-Time model to simulate repopulation in the primary tumour.</p> <p>Results</p> <p>The average probability of total tumour control increased from 38% with CONVT to 80% with IFP, to 85% with IMRT1 and 89% with IMRT2. The shorter treatment time and larger dose per fraction obtained with IMRT2 resulted in an 11% increase in the probability of control in the PTV1 with respect to IFP and 7% relatively to IMRT1 (p < 0.05). The average probability of total patient complications was reduced from 80% with CONVT to 61% with IFP and 31% with IMRT. The corresponding probability of complications in the ipsilateral parotid was 63%, 42% and 20%; in the contralateral parotid it was 50%, 20% and 9%; in the oral cavity it was 2%, 15% and 4% and in the mandible it was 1%, 5% and 3%, respectively.</p> <p>Conclusions</p> <p>A significant improvement in treatment outcome was obtained with IMRT compared to conventional radiation therapy. The practical and biological advantages of IMRT2, employing a shorter treatment time, may outweigh the small differences obtained in the organs at risk between the two IMRT techniques. This technique is therefore presently being used in the clinic for selected patients with head and neck tumours. A significant improvement in the quality of the dose distribution was obtained with IFP compared to CONVT. Thus, this beam arrangement is used in the clinical routine as an alternative to IMRT.</p

Physicochemical and microbiological effects of different sonication times on goat's milk yogurt.

SLACA, 12. De 4 a 7 de Novembro de 2017. Ref. 71861

Domains 12 to 16 of tropoelastin promote cell attachment and spreading through interactions with glycosaminoglycan and integrins alphaV and alpha5beta1

Elastin is an extracellular matrix component with key structural and biological roles in elastic tissues. Interactions between resident cells and tropoelastin, the monomer of elastin, underpin elastin’s regulation of cellular processes. However, the nature of tropoelastin–cell interactions and the contributions of individual tropoelastin domains to these interactions are only partly elucidated. In this study, we identified and characterized novel cell-adhesive sites in the tropoelastin N-terminal region between domains 12 and 16. We found that this region interacts with aV and a5b1 integrin receptors, which mediate cell attachment and spreading. A peptide sequence from within this region, spanning domains 14 to mid-domain 16, binds heparan sulfate through electrostatic interactions with peptide lysine residues and induces conformational ordering of the peptide. We propose that domains 14–16 direct initial cell attachment through cell-surface heparan sulfate glycosaminoglycans, followed by aV and a5b1 integrin-promoted attachment and spreading on domains 12–16 of tropoelastin. These findings advance our mechanistic understanding of elastin matrix biology, with the potential to enhance tissue regenerative outcomes of elastin-based materials

Gleam: the GLAST Large Area Telescope Simulation Framework

This paper presents the simulation of the GLAST high energy gamma-ray telescope. The simulation package, written in C++, is based on the Geant4 toolkit, and it is integrated into a general framework used to process events. A detailed simulation of the electronic signals inside Silicon detectors has been provided and it is used for the particle tracking, which is handled by a dedicated software. A unique repository for the geometrical description of the detector has been realized using the XML language and a C++ library to access this information has been designed and implemented.Comment: 10 pages, Late

Simulating the High Energy Gamma-ray sky seen by the GLAST Large Area Telescope

This paper presents the simulation of the GLAST high energy gamma-ray telescope. The simulation package, written in C++, is based on the Geant4 toolkit, and it is integrated into a general framework used to process events. A detailed simulation of the electronic signals inside Silicon detectors has been provided and it is used for the particle tracking, which is handled by a dedicated software. A unique repository for the geometrical description of the detector has been realized using the XML language and a C++ library to access this information has been designed and implemented. A new event display based on the HepRep protocol was implemented. The full simulation was used to simulate a full week of GLAST high energy gamma-ray observations. This paper outlines the contribution developed by the Italian GLAST software group.Comment: 6 pages, 4 figures, to be published in the Proceedings of the 6th International Symposium ''Frontiers of Fundamental and Computational Physics'' (FFP6), Udine (Italy), Sep. 26-29, 200