MCSTHAR++, a Monte Carlo code for the microcanonical hadronization

MCSTHAR++ is a new Monte Carlo code implementing the Statistical Hadronization Model. This model assumes that hadronization proceeds through the microcanonical decay of massive extended clusters. Unlike other hadronization models, in this approach very few free parameters are needed, as has been demonstrated in previous studies. The tuning of the model and the comparison with the data is ongoing.Comment: 3 pages; To appear in the proceedings of the conference IFAE 2010, Roma, Italy, 7-9 April 201

More loosely bound hadron molecules at CDF?

In a recent paper we have proposed a method to estimate the prompt production cross section of X(3872) at the Tevatron assuming that this particle is a loosely bound molecule of a D and a D*bar meson. Under this hypothesis we find that it is impossible to explain the high prompt production cross section found by CDF at sigma(X(3872)) \sim 30-70 nb as our theoretical prediction is about 300 times smaller than the measured one. Following our work, Artoisenet and Braaten, have suggested that final state interactions in the DD*bar system might be so strong to push the result we obtained for the cross section up to the experimental value. Relying on their conclusions we show that the production of another very narrow loosely bound molecule, the X_s=D_s D_s*bar, could be similarly enhanced. X_s should then be detectable at CDF with a mass of 4080 MeV and a prompt production cross section of sigma(X_s) \sim 1-3 nb.Comment: Minor revisions made. To appear in Phys Lett

Status and accuracy of the Monte Carlo generators for luminosity measurements

The status and accuracy of the precision Monte Carlo generators used for luminosity measurements at flavour factories is reviewed. It is shown that, thanks to a considerable, long-term effort in tuned comparisons between the predictions of independent programs, as well as in the validation of the generators against the presently available calculations of the next-to-next-to-leading order QED corrections to Bhabha scattering, the theoretical accuracy reached by the most precise tools is of about one per mille. This error estimate is valid for realistic experimental cuts, appears to be quite robust and is already sufficient for very accurate luminosity measurements. However, recent progress and possible advances to further improve it are also discussed.Comment: 6 pages, 1 table. Proceedings of the PhiPsi09 workshop, Oct. 13-16, 2009, Beijing, Chin

Novel decay dynamics revealed for virus-mediated drug activation in cytomegalovirus infection

Human cytomegalovirus (CMV) infection is a substantial cause of morbidity and mortality in immunocompromised hosts and globally is one of the most important congenital infections. The nucleoside analogue ganciclovir (GCV), which requires initial phosphorylation by the viral UL97 kinase, is the mainstay for treatment. To date, CMV decay kinetics during GCV therapy have not been extensively investigated and its clinical implications not fully appreciated. We measured CMV DNA levels in the blood of 92 solid organ transplant recipients with CMV disease over the initial 21 days of ganciclovir therapy and identified four distinct decay patterns, including a new pattern exhibiting a transient viral rebound (Hump) following initial decline. Since current viral dynamics models were unable to account for this Hump profile, we developed a novel multi-level model, which includes the intracellular role of UL97 in the continued activation of ganciclovir, that successfully described all the decline patterns observed. Fitting the data allowed us to estimate ganciclovir effectiveness in vivo (mean 92%), infected cell half-life (mean 0.7 days), and other viral dynamics parameters that determine which of the four kinetic patterns will ensue. An important clinical implication of our results is that the virological efficacy of GCV operates over a broad dose range. The model also raises the possibility that GCV can drive replication to a new lower steady state but ultimately cannot fully eradicate it. This model is likely to be generalizable to other anti-CMV nucleoside analogs that require activation by viral enzymes such as UL97 or its homologues

Is the X(3872) Production Cross Section at Tevatron Compatible with a Hadron Molecule Interpretation?

The X(3872) is universally accepted to be an exotic hadron. In this letter we assume that the X(3872) is a D0 \bar D0* molecule, as claimed by many authors, and attempt an estimate of its prompt production cross section at Tevatron. A comparison with CDF data allows to draw some qualitative conclusions about this statement.Comment: 4 pages, 4 figures, accepted for publication in Phys. Rev. Let

Survival of patients with spinal muscular atrophy type 1

BACKGROUND: Spinal muscular atrophy type 1 (SMA1) is a progressive disease and is usually fatal in the first year of life. METHODS: A retrospective chart review was performed of SMA1 patients and their outcomes according to the following choices: letting nature take its course (NT); tracheostomy and invasive mechanical ventilation (TV); continuous noninvasive respiratory muscle aid (NRA), including noninvasive ventilation; and mechanically assisted cough. RESULTS: Of 194 consecutively referred patients enrolled in this study (103 males, 91 females), NT, TV, and NRA were chosen for 121 (62.3%), 42 (21.7%), and 31 (16%) patients, respectively. Survival at ages 24 and 48 months was higher in TV than NRA users: 95% (95% confidence interval: 81.8%-98.8%) and 67.7% (95% confidence interval: 46.7%-82%) at age 24 months (P < .001) and 89.43% and 45% at age 48 months in the TV and NRA groups, respectively (P < .001). The choice of TV decreased from 50% (1992-1998) to 12.7% (2005-2010) (P < .005) with a nonstatistically significant increase for NT from 50% to 65%. The choice of NRA increased from 8.1% (1999-2004) to 22.7% (2005-2010) (P < .001). CONCLUSIONS: Long-term survival outcome is determined by the choice of the treatment. NRA and TV can prolong survival, with NRA showing a lower survival probability at ages 24 and 48 months. Copyright © 2013 by the American Academy of Pediatrics

A possibly inflated planet around the bright, young star DS Tuc A

The origin of the observed diversity of planetary system architectures is one of the main topic of the exoplanetary research. The detection of a statistically significant sample of planets around young stars allows us to study the early stages of planet formation and evolution, but only a handful of them is known so far. In this regard, a considerable contribution is expected from the NASA TESS satellite, which is now performing a survey of $\sim 85 \%$ of the sky to search for short-period transiting planets In its first month of operations, TESS found a planet candidate with an orbital period of 8.14 days around a member of the Tuc-Hor young association ($\sim$ 40 Myr), the G6V main component of the binary system DS\,Tuc. If confirmed, it would be the first transiting planet around a young star suitable for radial velocity and/or atmospheric characterization. We aim to validate the planetary nature of this companion and to measure its orbital and physical parameters. We obtain accurate planet parameters by coupling an independent reprocessing of the TESS light curve with improved stellar parameters and the dilution caused by the binary companion; we analyse high precision archival radial velocities to impose an upper limit of about 0.1 M$_{\rm Jup}$ on the planet mass; we finally rule out the presence of external companions beyond 40 au with adaptive optics images. We confirm the presence of a young, giant (${\rm R} = 0.50$ R$_{\rm Jup}$) planet having a not negligible possibility to be inflated (theoretical mass $\lesssim 20$ M$_{\oplus}$) around DS\,Tuc~A. We discuss the feasibility of mass determination, Rossiter-McLaughlin analysis and atmosphere characterization, allowed by the brightness of the star.Comment: 12 pages, 11 figures. Accepted for publication in A&

Photon pair production at flavour factories with per mille accuracy

We present a high-precision QED calculation, with 0.1% theoretical accuracy, of two photon production in $e^+ e^-$ annihilation, as required by more and more accurate luminosity monitoring at flavour factories. The accuracy of the approach, which is based on the matching of exact next-to-leading order corrections with a QED Parton Shower algorithm, is demonstrated through a detailed analysis of the impact of the various sources of radiative corrections to the experimentally relevant observables. The calculation is implemented in the latest version of the event generator BabaYaga, available for precision simulations of photon pair production at $e^+ e^-$ colliders of moderately high energies.Comment: 11 pages, 5 figures, 1 tabl