ln vivo prediction of body composition from the dilution space of the deuterium oxide in two lactating Spanish dairy breed ewes

Thirteen Churra (5 forty days and 8 seventy,days after lambing) and twelve Latxa (6 forty days and 6 a hundred and twenty days after lambing) lactating dairy ewes were used to obtain predicting equations of body fat, protein and energy from the live weight and the dilution space of deuterium oxide (SD20). Ewes were injected with 0.6 gD 20/kgo f live weight in the jugular vein and blood samples were collec5te, d7, 29 and 31 hours after infusion. The D20 content of blood water was determined by infrared spectrometry, and SDZO was calculated as the ratio between the weight of the injected D20 and its predicted concentration at zero time. After the last bleeding ewes were sheared and slaughtered and the body water, fat, protein, ash and energy were chemically determined. The Churra ewes presented 2% more water and 1.7% less protein in the fat free empty body 40 days than 70 days after lambing and fat free empty body water content decreased linearly (R=-0.60) with empty body fat content. There was however a close negative relationship (R2=0.97) between the fat and water content of the fleece free body weight. Neither the breed nor the stage of lactation significantly affect this relationship. Body water was predicted from SD20 with a residual standard deviation (RSD) of approximately kg when a pool equation was considered, though for a same SD20, the Latxa ewes presented 1.76 kg more water than the Churra ewes. Body fat and energy were predicted from the live weight and measured body water with a RSD of 0.437 kg and 6.85 Mcal, respectively, when a pool equation was considered. The adjusted means of body energy differed significantly between breeds and when this effect was taken into account the RSD diminished to 3.10 Mcal. When SDZO was substituted for measured body water, the resulting RSD were 0.980 kg and 6.85 Mcal, respectively. The intercept of the prediction equation of body fat differed significantly between breeds and when this effect was taken in account the RSD decreased to 0.703 kg. The accuracy of the body protein prediction from the ewes sheared body weight (RSD=0.56k9g from the pool equation and 0.282 kg for equation taking into account the breed effect) was not improved by the inclusion of SD20 as a second predictive variable. The stage of lactation did not significantly affect any of the equations studied

LabVIEW-based control and acquisition system for the dosimetric characterization of a silicon strip detector

Theaimofthisworkistopresentanewdataacquisition,control,andanalysissoftwaresystemwrittenin LabVIEW.Thissystemhasbeendesignedtoobtainthedosimetryofasiliconstripdetectorinpolyethylene. It allows the full automation of the experiments and data analysis required for the dosimetric characterization of silicon detectors. It becomes a useful tool that can be applied in the daily routine check of a beam accelerator.MINECO ICTI2013-2016/FPA2013-47327-C2-1-RMINECO ICTI2013-2016/FPA2014-53290-C2-2- PJunta de Andalucía P12-FQM-160

CSIC High Specialization Course on Cultural Heritage Intervention Models: Research, Protection, Conservation and Valorization: A training Experience from a complex research programme.

Comunicación presentada en la 18th Annual Meeting of the European Association of Archaeologists, celebrada en Helsinki del 29 de agosto al 1 de septiembre de 2012.In late 2007 the then called Ministry of Education and Science funded the Research Program on Technologies for the Conservation and Valorization of Cultural Heritage (TCP) within the CONSOLIDER -INGENIO 2010 call. In it 16 research groups take part, from the CSIC and 4 Spanish universities, articulating traditionally distant disciplines directly involved with Cultural Heritage. The base for working is the culture of cooperation and collaboration between groups in an interdisciplinary way. TCP was the only funded proposal of the call that focused on the study of Cultural Heritage. One of the main objectives of the project included training, so after valorizing different options, it was finally decided to opt for a CSIC High Specialization Course model. The aim was to create a postgraduate training strategy for preparing, in a truly specialized way, professionals with technical or scientific profile, who can become the best professionals working on cultural heritage. This course was an alternative possibility, different from formal university education. It also benefited from greater freedom in designing the course, choosing the participating teachers, and establishing the relationship between practical and theoretical aspects. This goal lies at the very foundations of the Consolider call and more specifically, also within TCP: strengthen and highlight the link between the interdisciplinary research, the professional practice and the social visibility of research through training, dissemination and knowledge transfer.Peer Reviewe

Metasurface Antennas: New Models, Applications and Realizations

This paper presents new designs, implementation and experiments of metasurface (MTS) antennas constituted by subwavelength elements printed on a grounded dielectric slab. These antennas exploit the interaction between a cylindrical surface wave (SW) wavefront and an anisotropic impedance boundary condition (BC) to produce an almost arbitrary aperture field. They are extremely thin and excited by a simple in-plane monopole. By tailoring the BC through the shaping of the printed elements, these antennas can be largely customized in terms of beam shape, bandwidth and polarization. In this paper, we describe new designs and their implementation and measurements. It is experimentally shown for the first time that these antennas can have aperture efficiency up to 70%, a bandwidth up to 30%, they can produce two different direction beams of high-gain and similar beams at two different frequencies, showing performances never reached before

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Cerebellar contributions to fear-based emotional processing: relevance to understanding the neural circuits involved in autism

Cerebellar networks have traditionally been linked to sensorimotor control. However, a large body of evidence suggests that cerebellar functions extend to non-motor realms, such as fear-based emotional processing and that these functions are supported by interactions with a wide range of brain structures. Research related to the cerebellar contributions to emotional processing has focussed primarily on the use of well-constrained conditioning paradigms in both human and non-human subjects. From these studies, cerebellar circuits appear to be critically involved in both conditioned and unconditioned responses to threatening stimuli in addition to encoding and storage of fear memory. It has been hypothesised that the computational mechanism underlying this contribution may involve internal models, where errors between actual and expected outcomes are computed within the circuitry of the cerebellum. From a clinical perspective, cerebellar abnormalities have been consistently linked to neurodevelopmental disorders, including autism. Importantly, atypical adaptive behaviour and heightened anxiety are also common amongst autistic individuals. In this review, we provide an overview of the current anatomical, physiological and theoretical understanding of cerebellar contributions to fear-based emotional processing to foster further insights into the neural circuitry underlying emotional dysregulation observed in people with autism

Pharmacogenetics of Donepezil and Memantine in Healthy Subjects

Donepezil and memantine are the most common drugs used for Alzheimer’s disease. Their low effectiveness could partly be explained by genetic factors. Thus, we aim to identify Single Nucleotide Polymorphisms (SNPs) associated with pharmacokinetics, pharmacodynamics, and the safety of donepezil and memantine. For this regard, 25 volunteers enrolled in a bioequivalence clinical trial were genotyped for 67 SNPs in 21 genes with a ThermoFisher QuantStudio 12K Flex Open‐ Array. The statistical strategy included a univariate analysis that analyzed the association of these SNPs with pharmacokinetic parameters or the development of adverse drug reactions (ADRs) fol-lowed by a Bonferroni‐corrected multivariate regression. Statistical analyses were performed with SPSS software v.21 and R commander (version v3.6.3). In the univariate analysis, fourteen and six-teen SNPs showed a significant association with memantine’s and donepezil’s pharmacokinetic pa-rameters, respectively. Rs20417 (PTGS2) was associated with the development of at least one ADR. However, none of these associations reached the significance threshold in the Bonferroni‐corrected multivariate analysis. In conclusion, we did not observe any significant association of the SNPs analyzed with memantine and donepezil pharmacokinetics or ADRs. Current evidence on memantine and donepezil pharmacogenetics does not justify their inclusion in pharmacogenetic guidelines.M. Navares is financed by the ICI20/00131 grant, Acción Estratégica en Salud 2017-2020, ISCIII. P. Zubiaur’s contract with CIBERehd is financed by the “Infraestructura de Medicina de Precisión asociada a la Ciencia y Tecnología (IMPaCT, IMP/00009)”, Instituto de Salud Carlos III (ISCIII