35 research outputs found
HE-LHC: The High-Energy Large Hadron Collider – Future Circular Collider Conceptual Design Report Volume 4
- Author
- Abada A.
- Abbrescia M.
- AbdusSalam S. S.
- Abdyukhanov I.
- Abelleira Fernandez J.
- Abramov A.
- Aburaia M.
- Acar A. O.
- Adzic P. R.
- Agrawal P.
- Aguilar-Saavedra J. A.
- Aguilera-Verdugo J. J.
- Ahnen J. von
- Aiba M.
- Aichinger I.
- Aielli G.
- Akay A.
- Akhundov A.
- Aksakal H.
- Albacete J. L.
- Albergo S.
- Alekou A.
- Aleksa M.
- Aleksan R.
- Alemany Fernandez R. M.
- Alexahin Y.
- Alioli S.
- Alipour Tehrani N.
- Allanach B. C.
- Allport P. P.
- Altınlı M.
- Altmannshofer W.
- Alía R. G.
- Ambrosio G.
- Amorim D.
- Amstutz O.
- Anderlini L.
- Andreazza A.
- Andreini M.
- Andriatis A.
- Andris C.
- Andronic A.
- Angelucci M.
- Antinori F.
- Antipov S. A.
- Antonelli M.
- Antonello M.
- Antonioli P.
- Antusch S.
- Anulli F.
- Apolinário L.
- Apollinari G.
- Apollonio A.
- Appelö D.
- Appleby R. B.
- Apyan A.
- Apyan A.
- Arbey A.
- Arbuzov A.
- Arduini G.
- Arı V.
- Arias S.
- Armesto N.
- Arnaldi R.
- Arsenyev S. A.
- Arzeo M.
- Asai S.
- Aslanides E.
- Astapovych D.
- Atanasov M.
- Atieh S.
- Attié D.
- Auchmann B.
- Audurier A.
- Aull S.
- Aumon S.
- Aune S.
- Avino F.
- Avrillaud G.
- Aydın G.
- Azatov A.
- Azuelos G.
- Azzi P.
- Azzolini O.
- Azzurri P.
- Aßmann R. W.
- Bacchetta N.
- Bacchiocchi E.
- Bachacou H.
- Baek Y. W.
- Baglin V.
- Bai Y.
- Baird S.
- Baker M. J.
- Baldwin M. J.
- Ball A. H.
- Ballarino A.
- Banerjee S.
- Barber D. P.
- Barducci D.
- Barjhoux P.
- Barna D.
- Barnaföldi G. G.
- Barnes M. J.
- Barr A.
- Barranco García J.
- Barreiro Guimarães da Costa J.
- Bartmann W.
- Baryshevsky V.
- Barzi E.
- Bass S. A.
- Bastianin A.
- Baudouy B.
- Bauer F.
- Bauer M.
- Baumgartner T.
- Bautista-Guzmán I.
- Bayındır C.
- Beaudette F.
- Bedeschi F.
- Bellafont I.
- Bellagamba L.
- Bellegarde N.
- Belli E.
- Bellingeri E.
- Bellini F.
- Bellomo G.
- Belomestnykh S.
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- Benedikt M.
- Bernardi G.
- Bernardi J.
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- Bernhardt J. M.
- Bernini C.
- Berriaud C.
- Bertarelli A.
- Bertolucci S.
- Besana M. I.
- Besançon M.
- Beznosov O.
- Bhat C.
- Bhat P.
- Biagini M. E.
- Biarrotte J.-L.
- Bibet Chevalier A.
- Bielert E. R.
- Biglietti M.
- Bilei G. M.
- Bilki B.
- Biscari C.
- Bishara F.
- Blanco-García O. R.
- Blas J. de
- Blekman F.
- Blondel A.
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- Blümlein J.
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- Bogomyagkov A.
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- Boland M. J.
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- Brückman De Renstrom P.
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- Buffat X.
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- Dubovyk I.
- Duda P.
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- Duellmann D.
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- Durante M.
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- El Khechen D.
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- Faus-Golfe A.
- Fawcett W. J.
- FCC Collaboration
- Felici G.
- Felsberger L.
- Ferdeghini C.
- Fernandez Navarro A. M.
- Fernández-Téllez A.
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- Florio M.
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- García Pérez M.
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- Garzia I.
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- Gerwig H.
- Giacomelli P.
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- Gianotti F.
- Giffoni F.
- Gil Costa M.
- Gilardoni S. S.
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- Giudice G. F.
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- Glukhov S.
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- Publication venue
- Springer Verlag
- Publication date
- 09/02/2021
- Field of study
Get PDFIn response to the 2013 Update of the European Strategy for Particle Physics (EPPSU), the Future Circular Collider (FCC) study was launched as a world-wide international collaboration hosted by CERN. The FCC study covered an energy-frontier hadron collider (FCC-hh), a highest-luminosity high-energy lepton collider (FCC-ee), the corresponding 100 km tunnel infrastructure, as well as the physics opportunities of these two colliders, and a high-energy LHC, based on FCC-hh technology. This document constitutes the third volume of the FCC Conceptual Design Report, devoted to the hadron collider FCC-hh. It summarizes the FCC-hh physics discovery opportunities, presents the FCC-hh accelerator design, performance reach, and staged operation plan, discusses the underlying technologies, the civil engineering and technical infrastructure, and also sketches a possible implementation. Combining ingredients from the Large Hadron Collider (LHC), the high-luminosity LHC upgrade and adding novel technologies and approaches, the FCC-hh design aims at significantly extending the energy frontier to 100 TeV. Its unprecedented centre-of-mass collision energy will make the FCC-hh a unique instrument to explore physics beyond the Standard Model, offering great direct sensitivity to new physics and discoveries
FCC-ee: The Lepton Collider – Future Circular Collider Conceptual Design Report Volume 2
- Author
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- Abbrescia M.
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- Wilkinson G.
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- Zupan J.
- Zurita J.
- Özcan V.
- Özdemir K.
- Publication venue
- Springer Verlag
- Publication date
- 14/11/2019
- Field of study
Get PDFFCC-ee: The Lepton Collider: Future Circular Collider Conceptual Design Report Volume 2
- Author
- Abada A
- Abbrescia M
- AbdusSalam SS
- Abdyukhanov I
- Abramov A
- Aburaia M
- Acar AO
- Adzic PR
- Agaliotis EL
- Agrawal P
- Aguilar-Saavedra JA
- Aguilera-Verdugo JJ
- Aiba M
- Aichinger I
- Aielli G
- Akay A
- Akhundov A
- Aksakal H
- Alaniz EC
- Albacete JL
- Albergo S
- Alekou A
- Aleksa M
- Aleksan R
- Alexahin Y
- Alia RG
- Alioli S
- Allanach BC
- Allport PP
- Altinli M
- Altmannshofer W
- Ambrosio G
- Amorim D
- Amstutz O
- Anderlini L
- Andreazza A
- Andreini M
- Andriatis A
- Andris C
- Andronic A
- Angelucci M
- Antinori F
- Antipov SA
- Antonelli M
- Antonello M
- Antonioli P
- Antusch S
- Anulli F
- Apolinario L
- Apollinari G
- Apollonio A
- Appelo D
- Appleby RB
- Apyan A
- Apyan A
- Arbey A
- Arbuzov A
- Arduini G
- Ari V
- Arias S
- Armesto N
- Arnaldi R
- Arsenyev SA
- Arzeo M
- Asai S
- Aslanides E
- Assmann RW
- Astapovych D
- Atanasov M
- Atieh S
- Attie D
- Auchmann B
- Audurier A
- Aull S
- Aumon S
- Aune S
- Avino F
- Avrillaud G
- Aydin G
- Azatov A
- Azuelos G
- Azzi P
- Azzolini O
- Azzurri P
- Bacchetta N
- Bacchiocchi E
- Bachacou H
- Baek YW
- Baglin V
- Bai Y
- Baird S
- Baker MJ
- Baldwin MJ
- Ball AH
- Ballarino A
- Banerjee S
- Barber DP
- Barducci D
- Barjhoux P
- Barna D
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- Barnes MJ
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- Behr JK
- Bellafont I
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- Bencivenni G
- Benedikt M
- Bermudez SI
- Bernardi G
- Bernardi J
- Bernet C
- Bernhardt JM
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- Bertarelli A
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- Briffa JA
- Britzger D
- Brodsky SJ
- Brooke JJ
- Bruce R
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- Brunner O
- Bruzual HM
- Bruzzone P
- Buffat X
- Bulyak E
- Burkart F
- Burkhardt H
- Burnet J-P
- Butin F
- Buttazzo D
- Butterworth A
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- Publication venue
- SPRINGER HEIDELBERG
- Publication date
- 01/06/2019
- Field of study
Get PDFIn response to the 2013 Update of the European Strategy for Particle Physics, the Future Circular Collider (FCC) study was launched, as an international collaboration hosted by CERN. This study covers a highest-luminosity high-energy lepton collider (FCC-ee) and an energy-frontier hadron collider (FCC-hh), which could, successively, be installed in the same 100 km tunnel. The scientific capabilities of the integrated FCC programme would serve the worldwide community throughout the 21st century. The FCC study also investigates an LHC energy upgrade, using FCC-hh technology. This document constitutes the second volume of the FCC Conceptual Design Report, devoted to the electron-positron collider FCC-ee. After summarizing the physics discovery opportunities, it presents the accelerator design, performance reach, a staged operation scenario, the underlying technologies, civil engineering, technical infrastructure, and an implementation plan. FCC-ee can be built with today’s technology. Most of the FCC-ee infrastructure could be reused for FCC-hh. Combining concepts from past and present lepton colliders and adding a few novel elements, the FCC-ee design promises outstandingly high luminosity. This will make the FCC-ee a unique precision instrument to study the heaviest known particles (Z, W and H bosons and the top quark), offering great direct and indirect sensitivity to new physics
FCC Physics Opportunities: Future Circular Collider Conceptual Design Report Volume 1
- Author
- Abada A
- Abbrescia M
- AbdusSalam SS
- Abdyukhanov I
- Abramov A
- Aburaia M
- Acar AO
- Adzic PR
- Agrawal P
- Aguilar-Saavedra JA
- Aguilera-Verdugo JJ
- Ahnen JV
- Aiba M
- Aichinger I
- Aielli G
- Akay A
- Akhundov A
- Aksakal H
- Alaniz EC
- Albacete JL
- Albergo S
- Alekou A
- Aleksa M
- Aleksan R
- Alexahin Y
- Alia RG
- Alioli S
- Allanach BC
- Allport PP
- Altinli M
- Altmannshofer W
- Amann RW
- Ambrosio G
- Amorim D
- Amstutz O
- Anderlini L
- Andreazza A
- Andreini M
- Andriatis A
- Andris C
- Andronic A
- Angelucci M
- Antinori F
- Antipov SA
- Antonelli M
- Antonello M
- Antonioli P
- Antusch S
- Anulli F
- Apolinario L
- Apollinari G
- Apollonio A
- Appeloe D
- Appleby RB
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- Valet JM
- Valizadeh R
- Valle JWF
- Vallecorsa S
- Vallone G
- van Leeuwen M
- van Riesen-Haupt L
- Varasteh M
- Vecchi L
- Vedrine P
- Velev G
- Veness R
- Ventura A
- Venturini Delsolaro W
- Verducci M
- Verhaaren CB
- Vernieri C
- Verweij AP
- Verwilligen O
- Viazlo O
- Vicini A
- Viehhauser G
- Vignaroli N
- Vignolo M
- Vita SD
- Vitrano A
- Vivarelli I
- Vlachos S
- Voelkl V
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- Vogt DM
- Volkov P
- Volpini G
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- Voutsinas GG
- Vysotsky V
- Wagner U
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- Wang K
- Wang L-T
- Wang R
- Ward BFL
- Was Z
- Watson NK
- Watson TP
- Weiland C
- Weinzierl S
- Welsch CP
- Wenninger J
- Widorski M
- Wiedemann UA
- Wienands H-U
- Wilkinson G
- Williams PH
- Winter A
- Wohlfahrt A
- Wojton T
- Wollmann D
- Womersley J
- Woog D
- Wu X
- Wulzer A
- Yanehsari MK
- Yanehsari MK
- Yang G
- Yang HJ
- Yao W-M
- Yazgan E
- Yermolchik V
- Yildiz HD
- Yilmaz A
- Yilmaz A
- Yoo H-D
- Yost SA
- You T
- Young C
- Yu F
- Yu T-T
- Zaborowska A
- Zadeh SG
- Zadeh SG
- Zahnd M
- Zanetti M
- Zanotto L
- Zawiejski L
- Zeiler P
- Zerlauth M
- Zernov SM
- Zevi Dell Porta G
- Zhang C
- Zhang H
- Zhang Y
- Zhang Z
- Zhao Z
- Zhong Y-M
- Zhou D
- Zhou J
- Zhuang P
- Zick G
- Zimmermann F
- Zinn-Justin J
- Zivkovic L
- Zlobin AV
- Zobov M
- Zupan J
- Zurita J
- Publication venue
- 'Springer Fachmedien Wiesbaden GmbH'
- Publication date
- 01/06/2019
- Field of study
Get PDFWe review the physics opportunities of the Future Circular Collider, covering its e+e-, pp, ep and heavy ion programmes. We describe the measurement capabilities of each FCC component, addressing the study of electroweak, Higgs and strong interactions, the top quark and flavour, as well as phenomena beyond the Standard Model. We highlight the synergy and complementarity of the different colliders, which will contribute to a uniquely coherent and ambitious research programme, providing an unmatchable combination of precision and sensitivity to new physics
HE-LHC: The High-Energy Large Hadron Collider: Future Circular Collider Conceptual Design Report Volume 4
- Author
- Abada A
- Abbrescia M
- AbdusSalam SS
- Abdyukhanov I
- Abelleira Fernandez J
- Abramov A
- Aburaia M
- Acar AO
- Adzic PR
- Agrawal P
- Aguilar-Saavedra JA
- Aguilera-Verdugo JJ
- Aiba M
- Aichinger I
- Aielli G
- Akay A
- Akhundov A
- Aksakal H
- Albacete JL
- Albergo S
- Alekou A
- Aleksa M
- Aleksan R
- Alemany Fernandez RM
- Alexahin Y
- Alia RG
- Alioli S
- Alipour Tehrani N
- Allanach BC
- Allport PP
- Altinli M
- Altmannshofer W
- Ambrosio G
- Amorim D
- Amstutz O
- Anderlini L
- Andreazza A
- Andreini M
- Andriatis A
- Andris C
- Andronic A
- Angelucci M
- Antinori F
- Antipov SA
- Antonelli M
- Antonello M
- Antonioli P
- Antusch S
- Anulli F
- Apolinario L
- Apollinari G
- Apollonio A
- Appeloe D
- Appleby RB
- Apyan A
- Apyan A
- Arbey A
- Arbuzov A
- Arduini G
- Ari V
- Arias S
- Armesto N
- Arnaldi R
- Arsenyev SA
- Arzeo M
- Asai S
- Aslanides E
- Assmann RW
- Astapovych D
- Atanasov M
- Atieh S
- Attie D
- Auchmann B
- Audurier A
- Aull S
- Aumon S
- Aune S
- Avino F
- Avrillaud G
- Aydin G
- Azatov A
- Azuelos G
- Azzi P
- Azzolini O
- Azzurri P
- Bacchetta N
- Bacchiocchi E
- Bachacou H
- Baek YW
- Baglin V
- Bai Y
- Baird S
- Baker MJ
- Baldwin MJ
- Ball AH
- Ballarino A
- Banerjee S
- Barber DP
- Barducci D
- Barjhoux P
- Barna D
- Barnafoldi GG
- Barnes MJ
- Barr A
- Barranco Garcia J
- Barreiro Guimaraes da Costa J
- Bartmann W
- Baryshevsky V
- Barzi E
- Bass SA
- Bastianin A
- Baudouy B
- Bauer F
- Bauer M
- Baumgartner T
- Bautista-Guzman I
- Bayindir C
- Beaudette F
- Bedeschi F
- Beguin M
- Bellafont I
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- Bellegarde N
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- Bellingeri E
- Bellini F
- Bellomo G
- Belomestnykh S
- Bencivenni G
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- Bernardi G
- Bernardi J
- Bernet C
- Bernhardt JM
- Bernini C
- Berriaud C
- Bertarelli A
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- Bovone G
- Bozbey A
- Bozovic Jelisavic I
- Bozzi C
- Bozzini D
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- de Blas J
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- De Lucia E
- de Rijk G
- De Roeck A
- de Vivie de Regie JB
- Deandrea A
- Debono CJ
- Deghaye S
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- Denner A
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- Duarte L
- Dubovyk I
- Duda P
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- Englert C
- Eriksson H
- Eskola KJ
- Esposito LS
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- Falkowski A
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- Farilla A
- Farinelli R
- Farinon S
- Faroughy DA
- Fartoukh SD
- Faus-Golfe A
- Fawcett WJ
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- Fiorendi S
- Fiorio C
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- Honorato CG
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- Ishino M
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- Jadach S
- Jamin DO
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- Jiang X
- Jimenez JM
- Jones MA
- Jones OR
- Jowett JM
- Jung S
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- Kannike K
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- Karpov I
- Kartal S
- Karyukhin A
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- Katharina Behr J
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- Thomas S
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- Yilmaz A
- Yilmaz A
- Yoo H-D
- Yost SA
- You T
- Young C
- Yu F
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- Zaborowska A
- Zadeh SG
- Zahnd M
- Zanetti M
- Zanotto L
- Zawiejski L
- Zeiler P
- Zerlauth M
- Zernov SM
- Zevi Dell Porta G
- Zhang C
- Zhang H
- Zhang Y
- Zhang Z
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- Zhong Y-M
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- Zinn-Justin J
- Zivkovic L
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- Zurita J
- Publication venue
- SPRINGER HEIDELBERG
- Publication date
- 01/07/2019
- Field of study
Get PDFIn response to the 2013 Update of the European Strategy for Particle Physics (EPPSU), the Future Circular Collider (FCC) study was launched as a world-wide international collaboration hosted by CERN. The FCC study covered an energy-frontier hadron collider (FCC-hh), a highest-luminosity high-energy lepton collider (FCC-ee), the corresponding 100 km tunnel infrastructure, as well as the physics opportunities of these two colliders, and a high-energy LHC, based on FCC-hh technology. This document constitutes the third volume of the FCC Conceptual Design Report, devoted to the hadron collider FCC-hh. It summarizes the FCC-hh physics discovery opportunities, presents the FCC-hh accelerator design, performance reach, and staged operation plan, discusses the underlying technologies, the civil engineering and technical infrastructure, and also sketches a possible implementation. Combining ingredients from the Large Hadron Collider (LHC), the high-luminosity LHC upgrade and adding novel technologies and approaches, the FCC-hh design aims at significantly extending the energy frontier to 100 TeV. Its unprecedented centre-of-mass collision energy will make the FCC-hh a unique instrument to explore physics beyond the Standard Model, offering great direct sensitivity to new physics and discoveries
FCC-hh: The Hadron Collider: Future Circular Collider Conceptual Design Report Volume 3
- Author
- Abada A
- Abbrescia M
- AbdusSalam SS
- Abdyukhanov I
- Abelleira Fernandez J
- Abramov A
- Aburaia M
- Acar AO
- Adzic PR
- Agrawal P
- Aguilar-Saavedra JA
- Aguilera-Verdugo JJ
- Aiba M
- Aichinger I
- Aielli G
- Akay A
- Akhundov A
- Aksakal H
- Albacete JL
- Albergo S
- Alekou A
- Aleksa M
- Aleksan R
- Alemany Fernandez RM
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 18/12/2018
- Field of study
Get PDFIn response to the 2013 Update of the European Strategy for Particle Physics (EPPSU), the Future Circular Collider (FCC) study was launched as a world-wide international collaboration hosted by CERN. The FCC study covered an energy-frontier hadron collider (FCC-hh), a highest-luminosity high-energy lepton collider (FCC-ee), the corresponding 100 km tunnel infrastructure, as well as the physics opportunities of these two colliders, and a high-energy LHC, based on FCC-hh technology. This document constitutes the third volume of the FCC Conceptual Design Report, devoted to the hadron collider FCC-hh. It summarizes the FCC-hh physics discovery opportunities, presents the FCC-hh accelerator design, performance reach, and staged operation plan, discusses the underlying technologies, the civil engineering and technical infrastructure, and also sketches a possible implementation. Combining ingredients from the Large Hadron Collider (LHC), the high-luminosity LHC upgrade and adding novel technologies and approaches, the FCC-hh design aims at significantly extending the energy frontier to 100 TeV. Its unprecedented centre of-mass collision energy will make the FCC-hh a unique instrument to explore physics beyond the Standard Model, offering great direct sensitivity to new physics and discoveries
HE-LHC: The High-Energy Large Hadron Collider
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- Abbrescia M
- AbdusSalam SS
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 18/12/2018
- Field of study
Get PDFIn response to the 2013 Update of the European Strategy for Particle Physics (EPPSU), the Future Circular Collider (FCC) study was launched as a world-wide international collaboration hosted by CERN. The FCC study covered an energy-frontier hadron collider (FCC-hh), a highest-luminosity high-energy lepton collider (FCC-ee), the corresponding 100 km tunnel infrastructure, as well as the physics opportunities of these two colliders, and a high-energy LHC, based on FCC-hh technology. This document constitutes the third volume of the FCC Conceptual Design Report, devoted to the hadron collider FCC-hh. It summarizes the FCC-hh physics discovery opportunities, presents the FCC-hh accelerator design, performance reach, and staged operation plan, discusses the underlying technologies, the civil engineering and technical infrastructure, and also sketches a possible implementation. Combining ingredients from the Large Hadron Collider (LHC), the high-luminosity LHC upgrade and adding novel technologies and approaches, the FCC-hh design aims at significantly extending the energy frontier to 100 TeV. Its unprecedented centre-of-mass collision energy will make the FCC-hh a unique instrument to explore physics beyond the Standard Model, offering great direct sensitivity to new physics and discoveries
FCC-hh: The Hadron Collider: Future Circular Collider Conceptual Design Report Volume 3
- Author
- Abada A
- Abbrescia M
- AbdusSalam SS
- Abdyukhanov I
- Abelleira Fernandez J
- Abramov A
- Aburaia M
- Acar AO
- Adzic PR
- Agrawal P
- Aguilar-Saavedra JA
- Aguilera-Verdugo JJ
- Aiba M
- Aichinger I
- Aielli G
- Akay A
- Akhundov A
- Aksakal H
- Albacete JL
- Albergo S
- Alekou A
- Aleksa M
- Aleksan R
- Alemany Fernandez RM
- Alexahin Y
- Alia RG
- Alioli S
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- Allanach BC
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- Publication venue
- SPRINGER HEIDELBERG
- Publication date
- 01/07/2019
- Field of study
Get PDFIn response to the 2013 Update of the European Strategy for Particle Physics (EPPSU), the Future Circular Collider (FCC) study was launched as a world-wide international collaboration hosted by CERN. The FCC study covered an energy-frontier hadron collider (FCC-hh), a highest-luminosity high-energy lepton collider (FCC-ee), the corresponding 100 km tunnel infrastructure, as well as the physics opportunities of these two colliders, and a high-energy LHC, based on FCC-hh technology. This document constitutes the third volume of the FCC Conceptual Design Report, devoted to the hadron collider FCC-hh. It summarizes the FCC-hh physics discovery opportunities, presents the FCC-hh accelerator design, performance reach, and staged operation plan, discusses the underlying technologies, the civil engineering and technical infrastructure, and also sketches a possible implementation. Combining ingredients from the Large Hadron Collider (LHC), the high-luminosity LHC upgrade and adding novel technologies and approaches, the FCC-hh design aims at significantly extending the energy frontier to 100 TeV. Its unprecedented centre of-mass collision energy will make the FCC-hh a unique instrument to explore physics beyond the Standard Model, offering great direct sensitivity to new physics and discoveries
Assessing viral metagenomics for the diagnosis of acute undifferentiated fever in returned travellers: a multicenter cohort study.
- Author
- Publication venue
- Publication date
- 06/04/2024
- Field of study
No full textUp to 45% of febrile returning travellers remain undiagnosed after a thorough diagnostic work-up, even at referral centres. Although metagenomic next-generation sequencing (mNGS) has emerged as a promising tool, evidence of its usefulness in imported fever is very limited.
Travellers returning with fever were prospectively recruited in three referral clinics from November 2017 to November 2019. Unbiased mNGS optimised for virus detection was performed on serum samples of participants with acute undifferentiated febrile illness (AUFI), and results were compared to those obtained by reference diagnostic methods (RDM).
Among 507 returned febrile travellers, 433(85.4%) presented with AUFI. Dengue virus (n = 86) and Plasmodium spp. (n = 83) were the most common causes of fever. 103/433(23.8%) AUFI remained undiagnosed at the end of the follow-up.Metagenomic next-generation sequencing unveiled potentially pathogenic microorganisms in 196/433(38.7%) AUFI. mNGS identifications were more common in patients with a shorter duration of fever (42.3% in ≤5 days vs 28.7% in >5 days, P = 0.005). Potential causes of fever were revealed in 25/103(24.2%) undiagnosed AUFI and 5/23(21.7%) travellers with severe undiagnosed AUFI. Missed severe aetiologies included eight bacterial identifications and one co-infection of B19 parvovirus and Aspergillus spp.Additional identifications indicating possible co-infections occurred in 29/316(9.2%) travellers with AUFI, and in 11/128(8.6%) travellers with severe AUFI, who had received a diagnosis through RDM. The most common co-infections detected in severe AUFI were caused by Gram-negative bacteria. Serum mNGS was unable to detect >50% of infectious diagnoses achieved by RDM and also yielded 607 non-pathogenic identifications.
mNGS of serum can be a valuable diagnostic tool for selected travellers with undiagnosed AUFI or severe disease in addition to reference diagnostic techniques, especially during the first days of symptoms. Nevertheless, mNGS results interpretation presents a great challenge. Further studies evaluating the performance of mNGS using different sample types and protocols tailored to non-viral agents are needed
The Global and the Local: Health in Latin American Indigenous Women
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- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
No full text
