Evaluation of the total photoabsorption cross sections for actinides from photofission data and model calculations

We have calculated the fission probabilities for 237-Np, 233,235,238-U, 232-Th, and nat-Pb following the absorption of photons with energies from 68 MeV to 3.77 GeV using the RELDIS Monte-Carlo code. This code implements the cascade-evaporation-fission model of intermediate-energy photonuclear reactions. It includes multiparticle production in photoreactions on intranuclear nucleons, pre-equilibrium emission, and the statistical decay of excited residual nuclei via competition of evaporation, fission, and multifragmentation processes. The calculations show that in the GeV energy region the fission process is not solely responsible for the entire total photoabsorption cross section, even for the actinides: ~55-70% for 232-Th, \~70-80% for 238-U, and ~80-95% for 233-U, 235-U, and 237-Np. This is because certain residual nuclei that are created by deep photospallation at GeV photon energies have relatively low fission probabilities. Using the recent experimental data on photofission cross sections for 237-Np and 233,235,238-U from the Saskatchewan and Jefferson Laboratories and our calculated fission probabilities, we infer the total photoabsorption cross sections for these four nuclei. The resulting cross sections per nucleon agree in shape and in magnitude with each other. However, disagreement in magnitude with total-photoabsorption cross-section data from previous measurements for nuclei from C to Pb calls into question the concept of a ``Universal Curve'' for the photoabsorption cross section per nucleon for all nuclei.Comment: 39 pages including 11 figure

The activation of the atypical PKC zeta in light-induced retinal degeneration and its involvement in L-DNase II control.

Light-induced retinal degeneration is characterized by photoreceptor cell death. Many studies showed that photoreceptor demise is caspase-independent. In our laboratory we showed that leucocyte elastase inhibitor/LEI-derived DNase II (LEI/L-DNase II), a caspase-independent apoptotic pathway, is responsible for photoreceptor death. In this work, we investigated the activation of a pro-survival kinase, the protein kinase C (PKC) zeta. We show that light exposure induced PKC zeta activation. PKC zeta interacts with LEI/L-DNase II and controls its DNase activity by impairing its nuclear translocation. These results highlight the role of PKC zeta in retinal physiology and show that this kinase can control caspase-independent pathways

Particle emission following Coulomb excitation in ultrarelativistic heavy-ion collisions

We study nuclear reactions induced by virtual photons associated with Lorentz-boosted Coulomb fields of ultrarelativistic heavy ions. Evaporation, fission and multifragmentation mechanisms are included in a new RELDIS code, which describes the deexcitation of residual nuclei formed after single and double photon absorption in peripheral heavy-ion collisions. Partial cross sections for different dissociation channels, including the multiple neutron emission ones, are calculated and compared with data when available. Rapidity and transverse momentum distributions of nucleons, nuclear fragments and pions, produced electromagnetically, are also calculated. These results provide important information for designing large-rapidity detectors and zero-degree calorimeters at RHIC and LHC. The electromagnetic dissociation of nuclei imposes some constrains on the investigation of exotic particle production in gamma-gamma fusion reactions.Comment: 26 LaTeX pages including 8 figures, uses epsf.st

Mutual heavy ion dissociation in peripheral collisions at ultrarelativistic energies

We study mutual dissociation of heavy nuclei in peripheral collisions at ultrarelativistic energies. Earlier this process was proposed for beam luminosity monitoring via simultaneous registration of forward and backward neutrons in zero degree calorimeters at Relativistic Heavy Ion Collider. Electromagnetic dissociation of heavy ions is considered in the framework of the Weizsacker-Williams method and simulated by the RELDIS code. Photoneutron cross sections measured in different experiments and calculated by the GNASH code are used as input for the calculations of dissociation cross sections. The difference in results obtained with different inputs provides a realistic estimation for the systematic uncertainty of the luminosity monitoring method. Contribution to simultaneous neutron emission due to grazing nuclear interactions is calculated within the abrasion model. Good description of CERN SPS experimental data on Au and Pb dissociation gives confidence in predictive power of the model for AuAu and PbPb collisions at RHIC and LHC.Comment: 46 pages with 7 tables and 13 figures, numerical integration accuracy improved, next-to-leading-order corrections include

A prognostic index predicting survival in transformed Waldenström macroglobulinemia

Histological transformation into diffuse large B-cell lymphoma is a rare complication in patients with Waldenström macroglobulinemia (WM) usually associated with a poor prognosis. The objective of this study was to develop and validate a prognostic index for survival in transformed WM patients. Through this multicenter, international collaborative effort, we developed a scoring system based on data from 133 patients with transformed WM who were evaluated between 1995 and 2016 (training cohort). Univariate and multivariate analyses were used to propose a prognostic index with 2-year survival after transformation as an end-point. For external validation, a data set of 67 patients was used to evaluate the performance of the model (validation cohort). By multivariate analysis, three adverse covariates were identified as independent predictors of 2-year survival after transformation: elevated serum LDH (2 points), platelet count < 100 x 109/L (1 point) and any previous treatment for WM (1 point). Three risk groups were defined: low-risk (0-1 point, 24% of patients), intermediate-risk (2-3 points, 59%, hazard ratio (HR) = 3.4) and high-risk (4 points, 17%, HR = 7.5). Two-year survival rates were 81%, 47%, and 21%, respectively (P < 0.0001). This model appeared to be a better discriminant than the International Prognostic Index (IPI) and the revised IPI (R-IPI). We validated this model in an independent cohort. This easy-to-compute scoring index is a robust tool that may allow identification of groups of transformed WM patients with different outcomes and could be used for improving the development of risk-adapted treatment strategies

A polynuclear iron complex, candidate as a member of the ferric “low-molecular-mass intracellular iron pool”: electrochemistry, reductive iron release and Fenton reaction

The trinuclear iron complex {[Fe(Ala)2H2O]3O}7+ which arises from spontaneous self-assembling of alanine and ferric salts has been studied as one of the possible candidates for the ferric part of the intracellular low molecular mass iron pool. Electrochemical studies in water have evidenced (i) the reversibility of the one-electron reduction into the mixed valence Fe(II)Fe(III)Fe(III) complex and (ii) the irreversibility of the total reduction which leads to the deposit of ferrous iron. The NAD(P)H : flavin oxidoreductase from E. coli has been shown to mobilize iron from the complex efficiently. In the presence of reducing agents, the complex promoted Fenton chemistry. These results argue in favour of the hypothesis that the complex may be a ferric constituent of the iron pool. At least, the complex is a possible model for in vitro studies of the properties of the iron pool