State-of-the-art survey of dissimilar metal joining by solid state welding

State-of-the-art of dissimilar metal joining by solid state diffusion bonding and roll and press welding, emphasizing stainless steel and aluminum allo

Optical structure and polarization of the western hot spot of Pictor A

HST images of the western hot spot of the nearby FRII radio galaxy Pictor A resolve the hot spot into an amorphous region of highly polarized wisps. The high polarization (>~ 50%) indicates that the optical emission is synchrotron radiation and that the magnetic field structure has been well resolved. The magnetic field is oriented nearly perpendicular to the jet axis and apparently very uniform. We interpret these observations in terms of a compressed magnetic field at the working surface where the jet impinges on the intergalactic medium some 100 kpc from the nucleus of the host galaxy. Keywords: Polarization --- radiation mechanisms: nonthermal --- galaxies: active --- galaxies: individual: Pictor A --- galaxies: jets.Comment: uuencoded compressed postscript. The preprint is also available at http://www.ast.cam.ac.uk/preprint/PrePrint.htm

H2A.Z facilitates access of active and repressive complexes to chromatin in embryonic stem cell self-renewal and differentiation.

SummaryChromatin modifications have been implicated in the self-renewal and differentiation of embryonic stem cells (ESCs). However, the function of histone variant H2A.Z in ESCs remains unclear. We show that H2A.Z is highly enriched at promoters and enhancers and is required for both efficient self-renewal and differentiation of murine ESCs. H2A.Z deposition leads to an abnormal nucleosome structure, decreased nucleosome occupancy, and increased chromatin accessibility. In self-renewing ESCs, knockdown of H2A.Z compromises OCT4 binding to its target genes and leads to decreased binding of MLL complexes to active genes and of PRC2 complex to repressed genes. During differentiation of ESCs, inhibition of H2A.Z also compromises RA-induced RARα binding, activation of differentiation markers, and the repression of pluripotency genes. We propose that H2A.Z mediates such contrasting activities by acting as a general facilitator that generates access for a variety of complexes, both activating and repressive

Climate Science, Development Practice, and Policy Interactions in Dryland Agroecological Systems

The literature on drought, livelihoods, and poverty suggests that dryland residents are especially vulnerable to climate change. However, assessing this vulnerability and sharing lessons between dryland communities on how to reduce vulnerability has proven difficult because of multiple definitions of vulnerability, complexities in quantification, and the temporal and spatial variability inherent in dryland agroecological systems. In this closing editorial, we review how we have addressed these challenges through a series of structured, multiscale, and interdisciplinary vulnerability assessment case studies from drylands in West Africa, southern Africa, Mediterranean Europe, Asia, and Latin America. These case studies adopt a common vulnerability framework but employ different approaches to measuring and assessing vulnerability. By comparing methods and results across these cases, we draw out the following key lessons: (1) Our studies show the utility of using consistent conceptual frameworks for vulnerability assessments even when quite different methodological approaches are taken; (2) Utilizing narratives and scenarios to capture the dynamics of dryland agroecological systems shows that vulnerability to climate change may depend more on access to financial, political, and institutional assets than to exposure to environmental change; (3) Our analysis shows that although the results of quantitative models seem authoritative, they may be treated too literally as predictions of the future by policy makers looking for evidence to support different strategies. In conclusion, we acknowledge there is a healthy tension between bottom-up/ qualitative/place-based approaches and top-down/quantitative/generalizable approaches, and we encourage researchers from different disciplines with different disciplinary languages, to talk, collaborate, and engage effectively with each other and with stakeholders at all levels

4-Dimensional BF Theory as a Topological Quantum Field Theory

Starting from a Lie group G whose Lie algebra is equipped with an invariant nondegenerate symmetric bilinear form, we show that 4-dimensional BF theory with cosmological term gives rise to a TQFT satisfying a generalization of Atiyah's axioms to manifolds equipped with principal G-bundle. The case G = GL(4,R) is especially interesting because every 4-manifold is then naturally equipped with a principal G-bundle, namely its frame bundle. In this case, the partition function of a compact oriented 4-manifold is the exponential of its signature, and the resulting TQFT is isomorphic to that constructed by Crane and Yetter using a state sum model, or by Broda using a surgery presentation of 4-manifolds.Comment: 15 pages in LaTe

The development of Drink Less: an alcohol reduction smartphone app for excessive drinkers

Excessive alcohol consumption poses a serious problem for public health. Digital behavior change interventions have the potential to help users reduce their drinking. In accordance with Open Science principles, this paper describes the development of a smartphone app to help individuals who drink excessively to reduce their alcohol consumption. Following the UK Medical Research Council’s guidance and the Multiphase Optimization Strategy, development consisted of two phases: (i) selection of intervention components and (ii) design and development work to implement the chosen components into modules to be evaluated further for inclusion in the app. Phase 1 involved a scoping literature review, expert consensus study and content analysis of existing alcohol apps. Findings were integrated within a broad model of behavior change (Capability, Opportunity, Motivation-Behavior). Phase 2 involved a highly iterative process and used the “Person-Based” approach to promote engagement. From Phase 1, five intervention components were selected: (i) Normative Feedback, (ii) Cognitive Bias Re-training, (iii) Self-monitoring and Feedback, (iv) Action Planning, and (v) Identity Change. Phase 2 indicated that each of these components presented different challenges for implementation as app modules; all required multiple iterations and design changes to arrive at versions that would be suitable for inclusion in a subsequent evaluation study. The development of the Drink Less app involved a thorough process of component identification with a scoping literature review, expert consensus, and review of other apps. Translation of the components into app modules required a highly iterative process involving user testing and design modification

Magellanic Cloud X-ray Sources: III. Completion of a ROSAT Survey

This paper concludes a series of three papers presenting ROSAT High-Resolution Imager (HRI) observations of unidentified Einstein and serendipitous ROSAT X-ray sources in the direction of the Magellanic Clouds. Accurate positions and fluxes have been measured for these sources. Optical photometry and spectroscopy were obtained to search for identifications in order to determine the physical nature of these sources. The present paper includes new data for 24 objects; identifications are given or confirmed for 30 sources. For six sources optical finding charts showing the X-ray positions are provided. The results from this program are summarized, showing the populations of luminous X-ray sources in the Magellanic Clouds are quite different from those in the Galaxy.Comment: 28 pages, 2 figures; to appear in Astronomical Journa

Spin Foam Models of Yang-Mills Theory Coupled to Gravity

We construct a spin foam model of Yang-Mills theory coupled to gravity by using a discretized path integral of the BF theory with polynomial interactions and the Barret-Crane ansatz. In the Euclidian gravity case we obtain a vertex amplitude which is determined by a vertex operator acting on a simple spin network function. The Euclidian gravity results can be straightforwardly extended to the Lorentzian case, so that we propose a Lorentzian spin foam model of Yang-Mills theory coupled to gravity.Comment: 10 page