Addiction to RUNX in lymphoma

No abstract available

RUNX oncoproteins and miRNA networks

News on: An AML1-ETO/miR-29b-1 regulatory circuit modulates phenotypic properties of acute myeloid leukemia cells by Zaidi et al. Oncotarget. 2017; 8:39994-40005. https://doi.org/10.18632/oncotarget.18127

Numerical solution of three-dimensional unsteady transonic flow over wings including inviscid/viscous interactions

A numerical procedure is presented for computing the unsteady transonic flow field about three dimensional swept wings undergoing general time dependent motion. The outer inviscid portion of the flow is assumed to be governed by the modified unsteady transonic small disturbance potential equation which is integrated in the time domain by means of an efficient alternating direction implicit approximate factorization algorithm. Gross dominant effects of the shock boundary layer interaction are accounted for by a simple empirically defined model. Viscous flow regions adjacent to the wing surface and in the trailing wake are described by a set of integral equations appropriate for compressible turbulent shear layers. The two dimensional boundary layer equations are applied quasi-statically stripwise across the span. Coupling with the outer inviscid flow is implemented through use of the displacement thickness concept within the limitations of small disturbance theory. Validity of the assumptions underlying the method is established by comparison with experimental data for the flow about a high aspect ratio transport wing having an advanced airfoil section

Aeroelastic loads prediction for an arrow wing. Task 1: Evaluation of R. P. White's method

The separated flow method is evaluated. This method was developed for moderately swept wings with multiple, constant strength vortex systems. The flow on the highly swept wing used in this evaluation is characterized by a single vortex system of continuously varying strength

Microscopic dynamics underlying the anomalous diffusion

The time dependent Tsallis statistical distribution describing anomalous diffusion is usually obtained in the literature as the solution of a non-linear Fokker-Planck (FP) equation [A.R. Plastino and A. Plastino, Physica A, 222, 347 (1995)]. The scope of the present paper is twofold. Firstly we show that this distribution can be obtained also as solution of the non-linear porous media equation. Secondly we prove that the time dependent Tsallis distribution can be obtained also as solution of a linear FP equation [G. Kaniadakis and P. Quarati, Physica A, 237, 229 (1997)] with coefficients depending on the velocity, that describes a generalized Brownian motion. This linear FP equation is shown to arise from a microscopic dynamics governed by a standard Langevin equation in presence of multiplicative noise.Comment: 4 pag. - no figures. To appear on Phys. Rev. E 62, September 200

Eastern Shona : a comparative dialect study

In this paper, the speech patterns of eleven individuals living in the Eastern half of Rhodesia are described and compared. Each individual was selected as being representative of a number of localities described in the map below. The first part of the paper is concerned with the abstraction of comparable linguistic units from the dialects. These units are abstracted at various levels of analysis and unit categories include phonemes, tonemes, morphophonemes, tonomorphemes and morphemes. Each unit category is described in relation to the general structural framework of the dialects established by a sentence analysis. The units so abstracted and described constitute the distinctive attributes of each dialect. In part two the dialects are compared and classified by computer according to their correspondence to approximately one thousand selected properties

Creative Interventions and Urban Revitalization

My thesis critiques Richard Florida’s notion of the creative class and Charles Landry’s ideas about the creative city to explore how these formulaic, homogenous approaches fail to adequately advance urban regeneration and community enhancement. In contrast to these approaches I examine the importance of interventionist, vernacular creative practices for urban revitalization. Considered are such vernacular endeavours as public artworks, community gardening, and arts and culture festivals. Specifically, I look to the example of London, Ontario to illustrate the ways in which communities can see, use, and appreciate their city differently. The concepts of placemaking and sense of place factor significantly in delineating alternative ways that independent, community organizations can work in line with initiatives posed by municipal governments to regenerate ailing urban spaces. Drawing on examples from different cities, various theoretical frameworks, and personal engagement through event planning and interviews, I seek to illustrate just how important and influential the everyday can be in engendering a culture of progressive civic betterment

Ferromagnetic material in the eastern red-spotted newt notophthalmus viridescens

Behavioral results obtained from the eastern red-spotted newt (Notophthalmus viridescens) led to the suggestion of a hybrid homing system involving inputs from both a light-dependent and a non-light-dependent mechanism. To evaluate the possible role of a receptor based on biogenic magnetite in this animal, we performed magnetometry experiments on a set of newts previously used in behavioral assays. The natural remanent magnetization (NRM) carried by these newts was strong enough to be measured easily using a direct-current-biased superconducting quantum interference device functioning as a moment magnetometer. Isothermal remanent magnetizations were two orders of magnitude higher than the NRM, suggesting that ferromagnetic material consistent with magnetite is present in the body of the newt. The NRM has no preferential orientation among the animals when analyzed relative to their body axis, and the demagnetization data show that, overall, the magnetic material grains are not aligned parallel to each other within each newt. Although the precise localization of the particles was not possible, the data indicate that magnetite is not clustered in a limited area. A quantity of single-domain magnetic material is present which would be adequate for use in either a magnetic intensity or direction receptor. Our data, when combined with the functional properties of homing, suggest a link between this behavioral response and the presence of ferromagnetic material, raising the possibility that magnetite is involved at least in the map component of homing of the eastern red-spotted newt

Extensions and improvements on XTRAN3S

Improvements to the XTRAN3S computer program are summarized. Work on this code, for steady and unsteady aerodynamic and aeroelastic analysis in the transonic flow regime has concentrated on the following areas: (1) Maintenance of the XTRAN3S code, including correction of errors, enhancement of operational capability, and installation on the Cray X-MP system; (2) Extension of the vectorization concepts in XTRAN3S to include additional areas of the code for improved execution speed; (3) Modification of the XTRAN3S algorithm for improved numerical stability for swept, tapered wing cases and improved computational efficiency; and (4) Extension of the wing-only version of XTRAN3S to include pylon and nacelle or external store capability

Additional development of the XTRAN3S computer program

Additional developments and enhancements to the XTRAN3S computer program, a code for calculation of steady and unsteady aerodynamics, and associated aeroelastic solutions, for 3-D wings in the transonic flow regime are described. Algorithm improvements for the XTRAN3S program were provided including an implicit finite difference scheme to enhance the allowable time step and vectorization for improved computational efficiency. The code was modified to treat configurations with a fuselage, multiple stores/nacelles/pylons, and winglets. Computer program changes (updates) for error corrections and updates for version control are provided