618 research outputs found
The Gauge Dual of Gauged N=8 Supergravity Theory
The most general SU(3)-singlet space of gauged N=8 supergravity in
four-dimensions is studied recently. The SU(3)-invariant six scalar fields are
realized by six real four-forms. A family of holographic N=1 supersymmetric RG
flows on M2-branes in three-dimensions is described. This family of flows is
driven by three independent mass parameters from the N=8 SO(8) theory and is
controlled by two IR fixed points, N=1 G_2-invariant one and N=2 SU(3) x
U(1)-invariant one. The generic flow with arbitrary mass parameters is N=1
supersymmetric and reaches to the N=2 SU(3) x U(1) fixed point where the three
masses become identical. A particular N=1 supersymmetric SU(3)-preserving RG
flow from the N=1 G_2-invariant fixed point to the N=2 SU(3) x U(1)-invariant
fixed point is also discussed.Comment: 19pp; added the footnote 1, improved the conclusion and to appear in
IJMP
Spectral Functions in Holographic Renormalization Group Flows
The spectrum of two-point functions in a holographic renormalization group
flow from an ultraviolet (UV) to an infrared (IR) conformal fixed point is
necessarily continuous. For a toy model, the spectral function does not only
show the expected UV and IR behaviours, but other interesting features such as
sharp peaks and oscillations in the UV. The spectral functions for the
SU(3)xU(1) flow in AdS_4/CFT_3 and the SU(2)xU(1) flow in AdS_5/CFT_4 are
calculated numerically. They exhibit a simple cross-over behaviour and
reproduce the conformal dimensions of the dual operators in the UV and IR
conformal phases.Comment: 20 pages, 6 figures v2: added referene
MiRNA deregulation targets specific pathways in leiomyosarcoma development: An in silico analysis
BackgroundMicroRNA (miRNA) mediate post-transcriptional gene repression and are involved in a variety of human diseases, including cancer. Soft tissue sarcomas are rare malignancies with a variety of histological subtypes which may occur virtually anywhere in the human body. Leiomyosarcoma is one of the most common subtypes, shows a smooth muscle phenotype and its cancerogenesis is still unclear. The aim of our study was to investigate the potential role of miRNA differential expression in leiomyosarcoma development.MethodsWe first employed the Sarcoma microRNA Expression Database, a repository that describes the patterns of over 1000 miRNA expression in various human sarcoma types, to identify differentially expressed miRNA comparing leiomyosarcoma and smooth muscle samples. Subsequently, we identified putative target genes of those miRNAs with the TargetScan prediction tool. Finally, we evaluated whether the retrieved pool of putative targets was enriched in genes belonging to specific molecular pathways by means of the Enrichr analysis tool. Protein-protein network analysis was analyzed by means of the STRING web tool.ResultsOut of 1120 miRNAs tested, the expression of 301 miRNAs was statistically significantly different between leiomyosarcoma and smooth muscle samples. The hypothetical targets could be predicted for 172 miRNAs. 438 genes were predicted to be the targets with high confidence (cumulative weighted context score cut-off level less than -1.0) and analyzed for belonging to specific molecular pathways. Pathway analysis suggested that RNA Polymerase III, tRNA functions and synaptic neurotransmission (with special regard to dopamine mediated signaling) could be involved in leiomyosarcoma development.ConclusionsOur results demonstrate that data mining of publicly available repositories can be useful to suggest molecular pathways underlying the pathogenesis of rare tumors such as leiomyosarcoma
Perturbing Around A Warped Product Of AdS_4 and Seven-Ellipsoid
We compute the spin-2 Kaluza-Klein modes around a warped product of AdS_4 and
a seven-ellipsoid. This background with global G_2 symmetry is related to a
U(N) x U(N) N=1 superconformal Chern-Simons matter theory with sixth order
superpotential. The mass-squared in AdS_4 is quadratic in G_2 quantum number
and KK excitation number. We determine the dimensions of spin-2 operators using
the AdS/CFT correspondence. The connection to N=2 theory preserving SU(3) x
U(1)_R is also discussed.Comment: 21pp; The second and last paragraphs of section 2, the footnotes 1
and 2 added and to appear in JHE
Notes on Supersymmetry Enhancement of ABJM Theory
We study the supersymmetry enhancement of ABJM theory. Starting from a supersymmetric Chern-Simons matter theory with gauge group
U(2)U(2) which is a truncated version of the ABJM theory, we find by
using the monopole operator that there is additional supersymmetry
related to the gauge group. We show this additional supersymmetry can combine
with supersymmetry of the original ABJM theory to an enhanced
SUSY with gauge group U(2)U(2) in the case . We
also discuss the supersymmetry enhancement of the ABJM theory with
U()U() gauge group and find a condition which should be satisfied
by the monopole operator.Comment: 23 pages, no figure, minor corrections, version to appear in JHE
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