Parent-Adolescent Communication and Adolescents\u27 Sexual Intentions

This study investigated the quality and quantity of sexual communication between teens and parents in relation to the teens\u27 sexual intentions. Perceptions about communication were examined of parents and adolescents of both genders separately. Both same- and cross-gender effects of parental communication on adolescent sexual intent ions were explored. Approximately 290 families (target teen and parent) were measured in pre- and posttests. Parents perceived higher quality communication with teens than teens did, but not necessarily more frequent sexual communication. As teens\u27 perceptions of quality of communication with mother and father went up, teens\u27 sexual intentions went down. The higher sons\u27 intention toward early sexual involvement, the more often sons perceived that their parents talked with them about sexual issues. Daughters who perceived more sexual communication with parents at Time 1 reported higher sexual intentions at Time 2. Fathers perceived that as quality and frequency of communication with daughter went up, the daughter\u27s sexual intentions also went up. Fathers perceived that as frequency of communication with all teens went up, the teen\u27s sexual intentions also went up. Mothers perceived that the higher the quality of communication with sons at Time 1, the higher the sexual intentions among sons at Time 2. The more often mothers perceived that their daughters talked with them about sexual issues at Time 1, the higher the daughters\u27 intention toward early sexual involvement at Time 2. The more the discrepancy between teens and fathers and mothers about communication quality, the more the adolescents\u27 intention toward early sexual involvement

Effects of improved home heating on asthma in community dwelling children: randomised controlled trial

Objective To assess whether non-polluting, more effective home heating (heat pump, wood pellet burner, flued gas) has a positive effect on the health of children with asthma

Turning collegial governance on its head : symbolic violence, hegemony and the academic board

This article draws on Bourdieu’s theorisation of domination and Gramsci’s notions of hegemony within the context of a larger empirical study of Australian university academic governance, and of academic boards (also known as academic senates or faculty senates) in particular. Reporting data that suggest a continued but radically altered form of collegial governance in which hegemony is exercised by management rather than by the professor, it theorises the domination of academic boards within western democratic universities. However, traditional collegial governance is also dependent upon a community of scholars, a role historically played by the academic board. In view of the suggested transition in collegial governance and the resultant convergence of academic work and management, the article concludes with questions about whether academic boards can continue to serve as communities of scholars in future

Nitroxyl (HNO) Stimulates Soluble Guanylyl Cyclase to Suppress Cardiomyocyte Hypertrophy and Superoxide Generation

Background: New therapeutic targets for cardiac hypertrophy, an independent risk factor for heart failure and death, are essential. HNO is a novel redox sibling of NON attracting considerable attention for the treatment of cardiovascular disorders, eliciting cGMP-dependent vasodilatation yet cGMP-independent positive inotropy. The impact of HNO on cardiac hypertrophy (which is negatively regulated by cGMP) however has not been investigated. Methods: Neonatal rat cardiomyocytes were incubated with angiotensin II (Ang II) in the presence and absence of the HNO donor Angeli’s salt (sodium trioxodinitrate) or B-type natriuretic peptide, BNP (all 1 mmol/L). Hypertrophic responses and its triggers, as well as cGMP signaling, were determined. Results: We now demonstrate that Angeli’s salt inhibits Ang II-induced hypertrophic responses in cardiomyocytes, including increases in cardiomyocyte size, de novo protein synthesis and b-myosin heavy chain expression. Angeli’s salt also suppresses Ang II induction of key triggers of the cardiomyocyte hypertrophic response, including NADPH oxidase (on both Nox2 expression and superoxide generation), as well as p38 mitogen-activated protein kinase (p38MAPK). The antihypertrophic, superoxide-suppressing and cGMP-elevating effects of Angeli’s salt were mimicked by BNP. We also demonstrate that the effects of Angeli’s salt are specifically mediated by HNO (with no role for NON or nitrite), with subsequent activation of cardiomyocyte soluble guanylyl cyclase (sGC) and cGMP signaling (on both cGMP-dependen

Comparative Analysis of Acinetobacters: Three Genomes for Three Lifestyles

Acinetobacter baumannii is the source of numerous nosocomial infections in humans and therefore deserves close attention as multidrug or even pandrug resistant strains are increasingly being identified worldwide. Here we report the comparison of two newly sequenced genomes of A. baumannii. The human isolate A. baumannii AYE is multidrug resistant whereas strain SDF, which was isolated from body lice, is antibiotic susceptible. As reference for comparison in this analysis, the genome of the soil-living bacterium A. baylyi strain ADP1 was used. The most interesting dissimilarities we observed were that i) whereas strain AYE and A. baylyi genomes harbored very few Insertion Sequence elements which could promote expression of downstream genes, strain SDF sequence contains several hundred of them that have played a crucial role in its genome reduction (gene disruptions and simple DNA loss); ii) strain SDF has low catabolic capacities compared to strain AYE. Interestingly, the latter has even higher catabolic capacities than A. baylyi which has already been reported as a very nutritionally versatile organism. This metabolic performance could explain the persistence of A. baumannii nosocomial strains in environments where nutrients are scarce; iii) several processes known to play a key role during host infection (biofilm formation, iron uptake, quorum sensing, virulence factors) were either different or absent, the best example of which is iron uptake. Indeed, strain AYE and A. baylyi use siderophore-based systems to scavenge iron from the environment whereas strain SDF uses an alternate system similar to the Haem Acquisition System (HAS). Taken together, all these observations suggest that the genome contents of the 3 Acinetobacters compared are partly shaped by life in distinct ecological niches: human (and more largely hospital environment), louse, soil

Large expert-curated database for benchmarking document similarity detection in biomedical literature search

Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research.Peer reviewe

What predicts health students’ self-reported preparedness to work in Indigenous health settings?

Australian undergraduate programs are implementing curriculum aimed at better preparing graduates to work in culturally diverse settings, but there remains uncertainty over the role of extant student attitudes towards Indigenous Australians. To begin to address this, we obtained baseline data on student attitudes upon entry to tertiary education. 1175 health science first-year students (275 males, 897 females) completed an anonymous in-class paper questionnaire. On average, students reported positive attitudes towards Indigenous Australians, with female students reporting more positive attitudes than male and domestic students more positive than international. Hierarchical multiple regression analyses indicated that after controlling for demographic variables, interactional diversity experiences and attitudes accounted for significant variance in a range of measures of preparedness to work in Indigenous health contexts. The knowledge gained will inform the development of, and alignment between, curriculum and pedagogical approaches, leading to an improved facilitation model for educators in the Indigenous Studies context

L’expérience ethnographique.

Cet article propose une analyse réflexive sur le partage et l’expérimentation des méthodes ethnographiques dans le cadre d’enseignements des sciences humaines et sociales en école d’architecture. Il est le fruit du travail et des échanges réguliers entre trois femmes anthropologues aux statuts et trajectoires différents qui privilégient l’approche ethnographique dans leurs recherches. Pour cette contribution, elles s’attachent à comprendre et à documenter la genèse d’une posture ethnographique chez leurs étudiant.e.s, faisant de cet apprentissage un objet anthropologique. Le propos éclaire les processus de réappropriation des savoirs et des savoirs faire ethnographiques tels que confrontés aux méthodes et aux habitus architecturaux, des logiques instrumentales à l’engouement pour le « terrain ». Ces questionnements seront abordés à l’aune de trois aspects: la place effective des sciences humaines et sociales dans le contexte des écoles d’architecture, le « terrain » et le « projet » analysés en tant que dispositifs initiatiques, et enfin les appropriations concrètes, observées en actes, de dispositions ethnographiques par les étudiant.e.s.This article proposes a reflexive analysis on sharing and experimenting with ethnographic methods, when teaching human and social sciences in French schools of architecture. It draws on exchanges between three women anthropologists working in such an institution who despite different statuses and backgrounds all use ethnographic approaches in their research and teaching. In this article, they seek to understand and document the genesis of an ethnographic posture in their students, making this an anthropological object of research. The aim is to shed light on the processes of reappropriation of ethnographic knowledge and know-how when confronted with architectural methods and habitus, from instrumental logics to the craze for the "field". These questions are explored in relation to the place of human and social sciences within the context of schools of architecture; an analysis of the "field" and the "project" taken as initiatory dispositifs; and, finally, an examination of the ways students appropriate diverse ethnographic techniques