Role of hormonal risk factors in HER2-positive breast carcinomas

Examination of parity, age at menarche and at menopause by HER2 status in a large series of breast carcinomas showed a statistically significant increased-frequency of HER2-positive tumours in lower risk subgroups. The findings suggest a difference in the protective role of hormone-related risk factors between HER2-positive and -negative tumour

Prognosis based on primary breast carcinoma instead of pathological nodal status.

In breast cancer patients, prognostic information required to plan post-surgical therapy is obtained mainly through axillary dissection. This study was designed to establish a new prognostic score based solely on parameters of the primary tumour as an alternative to axillary surgery in assessing prognosis. Eight different prognostic factors, including menopausal status, tumour size, grading, lymphatic invasion, desmoplasia, necrosis, c-erbB-2 and laminin receptor expression, were evaluated retrospectively on a large series of primary breast carcinoma patients. From multivariate analysis, four independent parameters were selected and examined, alone and in combination, for their prognostic potential. These parameters were used to generate a prognostic score that was analysed retrospectively in 467 N0-N1a patients to determine its predictive value for survival. The score, which includes variables such as tumour size, grading, laminin receptor and c-erbB-2 overexpression, was established based on the number of negative prognostic factors: score 1 refers to cases in which all four parameters reflect a good prognosis, scores 2 and 3 refer to tumours in which, respectively, one or two of the four parameters reflect a poor prognosis, whereas score 4 refers to tumours with three or four poor prognosis factors. Analysis of the overall survival of the four score groups shows that patients with score 1 tumours (22% of the total) had the best prognosis with a 15 year survival of 82%, patients with score 2 and 3 had an intermediate prognosis, whereas score 4 patients had the poorest prognosis with a 15 year survival of only 38%. Moreover, survival in the N+ score 1 cases was found to be longer than that in the total N- patients. Our data suggest that the primary tumour score provides more reliable prognostic information than pathological nodal status, and that axillary dissection can be avoided in a large number of patients

Distributed Leadership Agency and Work Outcomes: Validation of the Italian DLA and Its Relations With Commitment, Trust, and Satisfaction

Forms of collective leadership, such as distributed leadership, have become increasingly important. The need for measurement of the variables involved in the delegation processes represents a new challenge for organizations that want to ensure high-level working. The present study aimed to validate the Italian version of the distributed leadership agency (DLA). The study was carried out on 704 employees (doctors, nurses, clerks, staff workers, healthcare assistants, consultants, management) of an Italian public hospital, who were selected to complete a survey on organizational perceptions. Multiple confirmatory factor analyses (maximum likelihood) have been computed to explore the factorial structure of the DLA, along with associations with other work outcomes. Results about the Italian DLA confirmed the original trifactorial structure of the construct, suggested by Yukl (2002), through good fit indexes and reliability scores; moreover, consistent with the literature, DLA was strongly related to satisfaction, commitment, and trust. Results contribute to underline the robustness of the construct of DLA in different cultural sectors and provide a useful tool to be adopted in the Italian context

Longitudinal and azimuthal evolution of two-particle transverse momentum correlations in Pb–Pb collisions at sNN=2.76TeV

This paper presents the first measurements of the charge independent (CI) and charge dependent (CD) two-particle transverse momentum correlators G2CI and G2CD in Pb–Pb collisions at sNN=2.76TeV by the ALICE collaboration. The two-particle transverse momentum correlator G2 was introduced as a measure of the momentum current transfer between neighboring system cells. The correlators are measured as a function of pair separation in pseudorapidity (Δη) and azimuth (Δφ) and as a function of collision centrality. From peripheral to central collisions, the correlator G2CI exhibits a longitudinal broadening while undergoing a monotonic azimuthal narrowing. By contrast, G2CD exhibits a narrowing along both dimensions. These features are not reproduced by models such as HIJING and AMPT. However, the observed narrowing of the correlators from peripheral to central collisions is expected to result from the stronger transverse flow profiles produced in more central collisions and the longitudinal broadening is predicted to be sensitive to momentum currents and the shear viscosity per unit of entropy density η/s of the matter produced in the collisions. The observed broadening is found to be consistent with the hypothesized lower bound of η/s and is in qualitative agreement with values obtained from anisotropic flow measurements

Production of light-flavor hadrons in pp collisions at √s=7and√s=13TeV

The production of π±, K ±, KS0, K ∗(892) , p , ϕ(1020) , Λ , Ξ -, Ω -, and their antiparticles was measured in inelastic proton–proton (pp) collisions at a center-of-mass energy of s = 13 TeV at midrapidity (| y| < 0.5) as a function of transverse momentum (pT) using the ALICE detector at the CERN LHC. Furthermore, the single-particle pT distributions of KS0, Λ , and Λ ¯ in inelastic pp collisions at s=7 TeV are reported here for the first time. The pT distributions are studied at midrapidity within the transverse momentum range 0 ≤ pT≤ 20 GeV/c, depending on the particle species. The pT spectra, integrated yields, and particle yield ratios are discussed as a function of collision energy and compared with measurements at lower s and with results from various general-purpose QCD-inspired Monte Carlo models. A hardening of the spectra at high pT with increasing collision energy is observed, which is similar for all particle species under study. The transverse mass and xT≡2pT/s scaling properties of hadron production are also studied. As the collision energy increases from s = 7–13 TeV, the yields of non- and single-strange hadrons normalized to the pion yields remain approximately constant as a function of s, while ratios for multi-strange hadrons indicate enhancements. The pT-differential cross sections of π±, K ± and p (p ¯) are compared with next-to-leading order perturbative QCD calculations, which are found to overestimate the cross sections for π± and p (p ¯) at high pT

Measurement of D-0, D+, D+* and D-s(+) production in pp collisions at root s=5.02 TeV with ALICE

The measurements of the production of prompt D0, D+, D+, and Ds+ mesons in proton-proton (pp) collisions at TeV with the ALICE detector at the Large Hadron Collider (LHC) are reported. D mesons were reconstructed at mid-rapidity (|y|<0.5) via their hadronic decay channels D0K-+, D+K-++, D+D0+K-++, Ds+phi+K+K-+, and their charge conjugates. The production cross sections were measured in the transverse momentum interval 0<36 for D0, 1<36 for D+ and D+, and in 2<24 for Ds+ mesons. Thanks to the higher integrated luminosity, an analysis in finer pT bins with respect to the previous measurements at sTeV was performed, allowing for a more detailed description of the cross-section pT shape. The measured pT-differential production cross sections are compared to the results at s=7TeV and to four different perturbative QCD calculations. Its rapidity dependence is also tested combining the ALICE and LHCb measurements in pp collisions at s=5.02 TeV. This measurement will allow for a more accurate determination of the nuclear modification factor in p-Pb and Pb-Pb collisions performed at the same nucleon-nucleon centre-of-mass energy

Status of cosmic-ray antideuteron searches

The precise measurement of cosmic-ray antiparticles serves as important means for identifying the nature of dark matter. Recent years showed that identifying the nature of dark matter with cosmic-ray positrons and higher energy antiprotons is difficult, and has lead to a significantly increased interest in cosmic-ray antideuteron searches. Antideuterons may also be generated in dark matter annihilations or decays, offering a potential breakthrough in unexplored phase space for dark matter. Low-energy antideuterons are an important approach because the flux from dark matter interactions exceeds the background flux by more than two orders of magnitude in the low-energy range for a wide variety of models. This review is based on the "dbar14 - dedicated cosmic-ray antideuteron workshop", which brought together theorists and experimentalists in the field to discuss the current status, perspectives, and challenges for cosmic-ray antideuteron searches and discusses the motivation for antideuteron searches, the theoretical and experimental uncertainties of antideuteron production and propagation in our Galaxy, as well as give an experimental cosmic-ray antideuteron search status update. This report is a condensed summary of the article "Review of the theoretical and experimental status of dark matter identification with cosmic-ray antideuteron" (arXiv:1505.07785).Comment: 9 pages, 4 figures, ICRC 2015 proceeding

First determination of the one-proton induced Non-Mesonic Weak Decay width of p-shell {\Lambda}-Hypernuclei

Previous studies of proton and neutron spectra from Non-Mesonic Weak Decay of eight Lambda-Hypernuclei (A = 5-16) have been revisited. New values of the ratio of the two-nucleon and the one-proton induced decay widths, Gamma_2N/Gamma_p, are obtained from single proton spectra, Gamma_2N/Gamma_p = 0.50 +/- 0.24, and from neutron and proton coincidence spectra, Gamma_2N/Gamma_p = 0.36 +/- 0.14stat +0.05sys -0.04sys , in full agreement with previously published ones. With these values, a method is developed to extract the one-proton induced decay width in units of the free Lambda decay width, Gamma_p/Gamma_Lambda, without resorting to Intra Nuclear Cascade models but by exploiting only experimental data, under the assumption of a linear dependence on A of the Final State Interaction contribution. This is the first systematic determination ever done and it agrees within the errors with recent theoretical calculations.Comment: 16 pages, 3 figures, 2 table