The Ursinus Weekly, March 9, 1959

J. Robbins is \u2759 May queen; Court, committees are picked • Folk song concert presented, Mar. 21 • Juniors plan to present prom • Dr. Helen Cam to speak at Forum Wed. • Junior men should apply for Cub and Key • 90th anniversary of its charter celebrated by Ursinus on Feb. 19 • Campus Chest opens annual charity drive • APO plans for future events • SEAP hears pupils discuss teachers • Editorial: Giving? • Weavers • Letters to the editor • Sun dial was fast • Intramural night to be held Tuesday, March 24 • Badminton team wins third in row • Courtmen end season; Lose 2 more contests • Grapplers end season with 3-5 record • Religion in life week presented • Curtain Club begins tryouts for Spring play • Student faculty show to be new & different • Sophs present dancehttps://digitalcommons.ursinus.edu/weekly/1379/thumbnail.jp

The Ursinus Weekly, October 6, 1958

Helfferich succeeds McClure as President • Dr. Allan L. Rice has new Swedish book published • Messiah begins; Students register on Tues. and Wed. • New look in uniforms brightens band this year • APO holds open meeting Tues. evening, October 7 • Presidents speak: Welcome class of 1962 • Y starts program; Commissions meet • New jazz magazine hits the market • Spirit Committee plans dance • Doctor C. N. Parkinson to address Forum Tues. • Student teachers receive positions • Pre-medical society views symposium at Pennsylvania • New senators hold first meeting of Fall semester • Editorial: Entertainment • Letters to the editor • Selecting a house • Amigo speaks • Lantern chooses Miller, McCabe as new editors • Hockey squad to meet Swarthmore for first game • Soccermen begin practice; Season opens October 15 • Crusader\u27s early TD edges Bear eleven 6-0 • Middle Atlantic Conference opens season Oct. 2nd • Fall intramurals offer speedball • Danforth releases applications for graduate study • Dr. E. H. Miller appears on television program • But still try... • Former basketball coach dies of polio in Virginia • Last season • Cadaverism • Engagement • J. Von Koppenfels • Beta Sigma Lambda frat. holds dance Sat. at L.A.M. • Curtain Club reception planned for October 9https://digitalcommons.ursinus.edu/weekly/1367/thumbnail.jp

Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples

Funder: NCI U24CA211006Abstract: The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) curated consensus somatic mutation calls using whole exome sequencing (WES) and whole genome sequencing (WGS), respectively. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2,658 cancers across 38 tumour types, we compare WES and WGS side-by-side from 746 TCGA samples, finding that ~80% of mutations overlap in covered exonic regions. We estimate that low variant allele fraction (VAF < 15%) and clonal heterogeneity contribute up to 68% of private WGS mutations and 71% of private WES mutations. We observe that ~30% of private WGS mutations trace to mutations identified by a single variant caller in WES consensus efforts. WGS captures both ~50% more variation in exonic regions and un-observed mutations in loci with variable GC-content. Together, our analysis highlights technological divergences between two reproducible somatic variant detection efforts

Transition to Adult Services among Behaviorally Infected Adolescents with HIV: A Qualitative Study

Objectives: The present study aimed to describe the experiences of youth with behaviorally acquired HIV who transitioned to adult care, to identify difficulties encountered, and to explore areas for improvement. Methods: Semi-structured interviews were conducted with 10 young adults ranging from 24 to 29 years old. Themes were derived from coding participant interviews. Results: Participants experienced adolescent care providers as an important source of support, felt anxiety about transition, provided recommendations for improving the process, and described significant changes associated with adult HIV care. Conclusions: Findings support the development of a clear and structured transition process to address patients’ fears and worries through early communication, planning, and coordination for adult healthcare, highlighting the need for future research in this area

Emergence of Resistance in HIV-1 Integrase with Dolutegravir Treatment in a Pediatric Population from the IMPAACT P1093 Study.

P1093 is a multicenter, open-label, phase I/II study of pharmacokinetics, safety, and tolerability of dolutegravir plus an optimized background regimen in pediatric participants aged 4 weeks to &lt;18 years with HIV-1. Most participants were highly treatment experienced. We report the mechanisms of emergent integrase strand transfer inhibitor (INSTI) resistance among adolescents and children receiving dolutegravir. Plasma was collected at screening and near protocol-defined virologic failure (PDVF) for population-level and, for some samples, clonal-level integrase genotyping, phenotyping, and replication capacity. HIV-1 RNA was assessed in all available plasma samples. Phylogenetic analysis of clonal integrase sequences and homology modeling of HIV-1 intasome complexes containing resistance-associated substitutions were performed. Treatment-emergent INSTI resistance was detected in 8 participants who met PDVF criteria. The rare INSTI resistance-associated substitution G118R or R263K developed in 6 participants. The on-study secondary integrase substitution E157Q or L74I was observed in 2 participants. G118R reduced dolutegravir susceptibility and integrase replication capacity more than R263K and demonstrated greater reduction in susceptibility and integrase replication capacity when present with specific secondary integrase substitutions, including L74M, T66I, and E138E/K. Continuing evolution after R263K acquisition led to reduced dolutegravir susceptibility and integrase replication capacity. Structural examination revealed potential mechanisms for G118R- and R263K-mediated INSTI resistance. G118R and R263K INSTI resistance substitutions, which are distinct to second-generation INSTIs, were detected in adolescents and children with prior virologic failure who received dolutegravir. This study provides additional molecular and structural characterization of integrase to aid in the understanding of INSTI resistance mechanisms in antiretroviral-experienced populations. (This study has been registered at ClinicalTrials.gov under identifier NCT01302847.)