502 research outputs found
Reply to drs Bhatt and Hofmann
Coment on : The maximum effective needle-to-nerve distance for ultrasound-guided interscalene block: an exploratory study. [Reg Anesth Pain Med. 2014]]]>
interscalene block; patient
eng
oai:serval.unil.ch:BIB_7C5BB1A51EF1
2022-05-07T01:21:10Z
phdthesis
urnserval
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https://serval.unil.ch/notice/serval:BIB_7C5BB1A51EF1
Etude radiologique des lésions du parenchyme rénal chez 50 enfants atteints d'infection urinaire récidivante
Godat, Pierre-Michel
Université de Lausanne, Faculté de médecine
info:eu-repo/semantics/doctoralThesis
phdthesis
1978
fre
https://serval.unil.ch/resource/serval:BIB_7C5BB1A51EF1.P001/REF.pdf
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info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_7C5BB1A51EF19
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Restricted: indefinite embargo
Copying allowed only for non-profit organizations
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oai:serval.unil.ch:BIB_7C5D453F3147
2022-05-07T01:21:10Z
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https://serval.unil.ch/notice/serval:BIB_7C5D453F3147
HLA and HIV: modeling adaptation to moving targets.
info:doi:10.1038/sj.tpj.6500200
info:eu-repo/semantics/altIdentifier/doi/10.1038/sj.tpj.6500200
info:eu-repo/semantics/altIdentifier/pmid/14583794
Telenti, A.
Beckmann, J.S.
Mallal, S.
info:eu-repo/semantics/article
article
2003
The pharmacogenomics journal, vol. 3, no. 5, pp. 254-256
info:eu-repo/semantics/altIdentifier/pissn/1470-269X
urn:issn:1470-269X
Animals; Gene Targeting/methods; HIV/genetics; HLA Antigens/genetics; Humans
eng
oai:serval.unil.ch:BIB_7C5D5BD8F500
2022-05-07T01:21:10Z
openaire
documents
urnserval
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https://serval.unil.ch/notice/serval:BIB_7C5D5BD8F500
Overexpressed or intraperitoneally injected human transferrin prevents photoreceptor degeneration in rd10 mice.
info:eu-repo/semantics/altIdentifier/pmid/21179240
Picard, E.
Jonet, L.
Sergeant, C.
Vesvres, M.H.
Behar-Cohen, F.
Courtois, Y.
Jeanny, J.C.
info:eu-repo/semantics/article
article
2010
Molecular Vision, vol. 16, pp. 2612-2625
info:eu-repo/semantics/altIdentifier/eissn/1090-0535
urn:issn:1090-0535
<![CDATA[PURPOSE: Retinal degeneration has been associated with iron accumulation in age-related macular degeneration (AMD), and in several rodent models that had one or several iron regulating protein impairments. We investigated the iron concentration and the protective role of human transferrin (hTf) in rd10 mice, a model of retinal degeneration.
METHODS: The proton-induced X-ray emission (PIXE) method was used to quantify iron in rd10 mice 2, 3, and 4 weeks after birth. We generated mice with the β-phosphodiesterase mutation and hTf expression by crossbreeding rd10 mice with TghTf mice (rd10/hTf mice). The photoreceptor loss and apoptosis were evaluated by terminal deoxynucleotidyl transferase dUTP nick end labeling in 3-week-old rd10/hTf mice and compared with 3-week-old rd10 mice. The neuroprotective effect of hTf was analyzed in 5-day-old rd10 mice treated by intraperitoneal administration with hTf for up to 25 days. The retinal hTf concentrations and the thickness of the outer nuclear layer were quantified in all treated mice at 25 days postnatally.
RESULTS: PIXE analysis demonstrated an age-dependent iron accumulation in the photoreceptors of rd10 mice. The rd10/hTf mice had the rd10 mutation, expressed high levels of hTf, and showed a significant decrease in photoreceptor death. In addition, rd10 mice intraperitoneally treated with hTf resulted in the retinal presence of hTf and a dose-dependent reduction in photoreceptor degeneration.
CONCLUSIONS: Our results suggest that iron accumulation in the retinas of rd10 mutant mice is associated with photoreceptor degeneration. For the first time, the enhanced survival of cones and rods in the retina of this model has been demonstrated through overexpression or systemic administration of hTf. This study highlights the therapeutic potential of Tf to inhibit iron-induced photoreceptor cell death observed in degenerative diseases such as retinitis pigmentosa and age-related macular degeneration
Enabling low power acoustics for capillary sonoreactors
Capillary reactors demonstrate outstanding potential for on-demand flow chemistry applications. However, non-uniform distribution of multiphase flows, poor solid handling, and the risk of clogging limit their usability for continuous manufacturing. While ultrasonic irradiation has been traditionally applied to address some of these limitations, their acoustic efficiency, uniformity and scalability to larger reactor systems are often disregarded. In this work, high-speed microscopic imaging reveals how cavitation-free ultrasound can unclog and prevent the blockage of capillary reactors. Modeling techniques are then adapted from traditional acoustic designs and applied to simulate and prototype sonoreactors with wider and more uniform sonication areas. Blade-, block- and cylindrical shape sonotrodes are optimized to accommodate longer capillary lengths in sonoreactors resonating at 28 kHz. Finally, a novel helicoidal capillary sonoreactor is proposed to potentially deal with a high concentration of solid particles in miniaturized flow chemistry. The acoustic designs and first principle rationalization presented here offer a transformative step forward in the scale-up of efficient capillary sonoreactors.This research was partially funded by the EU project MAPSYN (Microwave, Acoustic and Plasma SYNtheses) developed in the group of Photochemistry and Electrochemistry of Semiconductors (GFES) at the University of Alicante (Spain), under grant agreement No. CP-IP 309376 of the European Union Seventh Framework Program
Integral representation of the linear Boltzmann operator for granular gas dynamics with applications
We investigate the properties of the collision operator associated to the
linear Boltzmann equation for dissipative hard-spheres arising in granular gas
dynamics. We establish that, as in the case of non-dissipative interactions,
the gain collision operator is an integral operator whose kernel is made
explicit. One deduces from this result a complete picture of the spectrum of
the collision operator in an Hilbert space setting, generalizing results from
T. Carleman to granular gases. In the same way, we obtain from this integral
representation of the gain operator that the semigroup in L^1(\R \times \R,\d
\x \otimes \d\v) associated to the linear Boltzmann equation for dissipative
hard spheres is honest generalizing known results from the first author.Comment: 19 pages, to appear in Journal of Statistical Physic
A cortical potential reflecting cardiac function
Emotional trauma and psychological stress can precipitate cardiac arrhythmia and sudden death through arrhythmogenic effects of efferent sympathetic drive. Patients with preexisting heart disease are particularly at risk. Moreover, generation of proarrhythmic activity patterns within cerebral autonomic centers may be amplified by afferent feedback from a dysfunctional myocardium. An electrocortical potential reflecting afferent cardiac information has been described, reflecting individual differences in interoceptive sensitivity (awareness of one's own heartbeats). To inform our understanding of mechanisms underlying arrhythmogenesis, we extended this approach, identifying electrocortical potentials corresponding to the cortical expression of afferent information about the integrity of myocardial function during stress. We measured changes in cardiac response simultaneously with electroencephalography in patients with established ventricular dysfunction. Experimentally induced mental stress enhanced cardiovascular indices of sympathetic activity (systolic blood pressure, heart rate, ventricular ejection fraction, and skin conductance) across all patients. However, the functional response of the myocardium varied; some patients increased, whereas others decreased, cardiac output during stress. Across patients, heartbeat-evoked potential amplitude at left temporal and lateral frontal electrode locations correlated with stress-induced changes in cardiac output, consistent with an afferent cortical representation of myocardial function during stress. Moreover, the amplitude of the heartbeat-evoked potential in the left temporal region reflected the proarrhythmic status of the heart (inhomogeneity of left ventricular repolarization). These observations delineate a cortical representation of cardiac function predictive of proarrhythmic abnormalities in cardiac repolarization. Our findings highlight the dynamic interaction of heart and brain in stress-induced cardiovascular morbidity
Integrative analyses identify modulators of response to neoadjuvant aromatase inhibitors in patients with early breast cancer
Introduction
Aromatase inhibitors (AIs) are a vital component of estrogen receptor positive (ER+) breast cancer treatment. De novo and acquired resistance, however, is common. The aims of this study were to relate patterns of copy number aberrations to molecular and proliferative response to AIs, to study differences in the patterns of copy number aberrations between breast cancer samples pre- and post-AI neoadjuvant therapy, and to identify putative biomarkers for resistance to neoadjuvant AI therapy using an integrative analysis approach.
Methods
Samples from 84 patients derived from two neoadjuvant AI therapy trials were subjected to copy number profiling by microarray-based comparative genomic hybridisation (aCGH, n = 84), gene expression profiling (n = 47), matched pre- and post-AI aCGH (n = 19 pairs) and Ki67-based AI-response analysis (n = 39).
Results
Integrative analysis of these datasets identified a set of nine genes that, when amplified, were associated with a poor response to AIs, and were significantly overexpressed when amplified, including CHKA, LRP5 and SAPS3. Functional validation in vitro, using cell lines with and without amplification of these genes (SUM44, MDA-MB134-VI, T47D and MCF7) and a model of acquired AI-resistance (MCF7-LTED) identified CHKA as a gene that when amplified modulates estrogen receptor (ER)-driven proliferation, ER/estrogen response element (ERE) transactivation, expression of ER-regulated genes and phosphorylation of V-AKT murine thymoma viral oncogene homolog 1 (AKT1).
Conclusions
These data provide a rationale for investigation of the role of CHKA in further models of de novo and acquired resistance to AIs, and provide proof of concept that integrative genomic analyses can identify biologically relevant modulators of AI response
Reduction of Dispersion in Ultrasonically-Enhanced Micropacked Beds
Channeling of gas can reduce mass transfer performance in multiphase micropacked-bed reactors. Viscous and capillary forces cause this undesired and often unpredictable phenomenon in systems with catalyst particle sizes of hundreds of micrometers. In this work, we acoustically modify flow in a micropacked-bed reactor to reduce gas channeling by applying high-power sonication at low ultrasonic frequencies (∼40 kHz). Experimental residence time distributions reveal two orders of magnitude reduction in dispersion with ultrasound, allowing for nearly plug-flow behavior at high flow rates in the bed. Sonication appears to partially fluidize the packed-bed under pressurized cocurrent two-phase flow, effectively improving dispersion characteristics.This research was partially funded by the EU project MAPSYN: Microwave, Acoustic and Plasma SYNtheses, under Grant CPIP 309376 of the European Union Seventh Framework Program
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