The Clinical Sociologist as a Boundary Manager: The Case of University Administration

Managing conflicts at the interfaces or boundaries at the individual, group and organizational levels is an essential part of the job of a university administrator. As universities become subject to increasing external pressures, especially financial, administrators are called upon to reorganize, restructure and reallocate resources. These interventions substantially challenge academic administrators and the clinical sociologists who occupy these roles to utilize their skills as conflict and risk managers. This paper describes and discusses the experiences and observations of the authors as boundary managers in university settings

Wirkortäquilibration, Anschlagzeit, "time to peak effect": Bedeutung pharmakokinetisch-dynamischer Prinzipien für die tägliche klinische Praxis

Zusammenfassung: In der anästhesiologischen Pharmakologie spielen im Gegensatz zur internistischen Pharmakologie "Non-steady-state-Phänomene" eine herausragende Rolle. Ihr Verständnis ist eine Conditio sine qua non für die sichere und effiziente Applikation von anästhesierelevanten Medikamenten. Insbesondere die Verfügbarkeit der "optimierten target controlled infusion" ("optimized TCI"), von TCI-Systemen mit Ansteuerung des Effektkompartiments und dem relativ geringen Dosierungsspielraum bei "conscious sedation" unter erhaltener Spontanatmung verlangen von Anästhesisten, sich mit dem Konzept des Konzentrationsverlaufes am Wirkort auseinander zu setzen. Der Leser wird in die grundlegende Problematik eingeführt. Anwendungen der Prinzipien bei der Applikation von Muskelrelaxanzien, Propofol mit TCI-Systemen, volatilen Anästhetika und Opiaten werden erläuter

Targeted and untargeted metabolic profiling to discover bioactive compounds in seaweeds and hemp using gas and liquid chromatography-mass spectrometry

Greenhouse gas emissions are a global problem facing the dairy/beef industry. Novel feed additives consisting of seaweeds and hemp containing bioactive compounds are theorized to reduce enteric methane emissions. In this study we aimed to investigate the metabolic profiles of brown, red and green seaweeds and hemp using gas chromatography and liquid chromatography mass spectrometry. We used targeted and untargeted approaches, quantifying known halomethanes and phenolics, as well as identifying potentially novel bioactive compounds with anti-methanogenic properties. The main findings were: (a) Asparagopsis taxiformis contained halomethanes, with high concentrations of bromoform (4200 µg/g DW), six volatile halocarbons were tentatively identified; (b) no halomethanes were detected in the other studied seaweeds nor in hemp; (c) high concentrations of lignans were measured in hemp; (d) a high numbers of sulfated phenolic acids and unidentified sulfuric acid-containing compounds were detected in all seaweeds; (e) flavonoid glucosides and glucuronides were mainly identified in hemp; and (f) the condensed tannin gallocatechin was tentatively identified in Fucus sp. Using the combined metabolomics approach, an overview and in-depth information on secondary metabolites were provided. Halomethanes of Asparagopsis sp. have already been shown to be anti-methanogenic; however, metabolic profiles of seaweeds such as Dictyota and Sargassum have also been shown to contain compounds that may have anti-methanogenic potential

Micro-crystalline inclusions analysis by PIXE and RBS

A characteristic feature of the nuclear microprobe using a 3 MeV proton beam is the long range of particles (around 70 \mu m in light matrices). The PIXE method, with EDS analysis and using the multilayer approach for treating the X-ray spectrum allows the chemistry of an intra-crystalline inclusion to be measured, provided the inclusion roof and thickness at the impact point of the beam (Z and e, respectively) are known (the depth of the inclusion floor is Z + e). The parameter Z of an inclusion in a mineral can be measured with a precision of around 1 \mu m using a motorized microscope. However, this value may significantly depart from Z if the analyzed inclusion has a complex shape. The parameter e can hardly be measured optically. By using combined RBS and PIXE measurements, it is possible to obtain the geometrical information needed for quantitative elemental analysis. This paper will present measurements on synthetic samples to investigate the advantages of the technique, and also on natural solid and fluid inclusions in quartz. The influence of the geometrical parameters will be discussed with regard to the concentration determination by PIXE. In particular, accuracy of monazite micro-inclusion dating by coupled PIXE-RBS will be presented

Tectonic geomorphology and late Quaternary deformation on the Ragged Mountain fault, Yakutat microplate, south coastal Alaska

The 33 km-long Ragged Mountain fault (RMF) forms the northwestern corner of the Yakutat Terrane, which is colliding with the North American plate in south coastal Alaska at ~5.5 cm/yr. The fault zone contains three types of scarps in a zone up to 175 m wide: (1) antislope scarps on the lower range front, (2) a sinuous thrust scarp at the toe of the range front, and (3) a swarm of flexural-slip scarps on the footwall. Trenches across the first two scarp types reveal evidence for two Holocene surface ruptures, plus several late Pleistocene ruptures. In the antislope scarp trench, ruptures occurred at 0.5–3.9 ka; slightly younger than 8.3 ka; and at 18.1–21.8 ka (recurrence intervals 4.4–8 kyr and 9.8–13.3 kyr). Displacements per event ranged from 15 to 40 cm. In the thrust trench ruptures are dated at 2.8–5.9 ka; 5.9–17.2 ka, and 17.2–44.9 ka (mean recurrence intervals 7.2 kyr and 19.5 kyr). Displacements per event ranged from 26 to 77 cm. We interpret the thrust fault as the primary seismogenic structure, and its largest trench displacement (77 cm) equates to the average displacement expected for a 33 km-long reverse rupture. The flexural-slip scarp, in contrast, was rapidly formed ca. 4 ka but its sag pond sediments have continued to slowly fold up to present. The southern third of the fault is dominated by large gravitational failures of the range front (as large as 2.5 km wide, 0.6-0.7 km long, and 200–250 m thick), which head in a linear, 40 m-deep range-crest trough filled with lakes, a classic expression of deep-seated gravitational slope deformation