Is Turkey’s Foreign Policy Moving East?

The Justice and Development Party (Adalet ve Kalkınma Partisi, AKP) of Turkey has reoriented its country\u27s historical Westward-looking foreign policy towards the Middle East because of a freeze in European Union accession, trans-national security issues resulting from the Kurdistan Worker\u27s Party (PKK), and the expansion of its economic interests into the region. The United States should take careful note of these changes in an effort to mitigate any opposition to the AKP’s policies, as well as to better utilize Turkey’s growing clout in the region

myGRN: a database and visualisation system for the storage and analysis of developmental genetic regulatory networks

<p>Abstract</p> <p>Background</p> <p>Biological processes are regulated by complex interactions between transcription factors and signalling molecules, collectively described as Genetic Regulatory Networks (GRNs). The characterisation of these networks to reveal regulatory mechanisms is a long-term goal of many laboratories. However compiling, visualising and interacting with such networks is non-trivial. Current tools and databases typically focus on GRNs within simple, single celled organisms. However, data is available within the literature describing regulatory interactions in multi-cellular organisms, although not in any systematic form. This is particularly true within the field of developmental biology, where regulatory interactions should also be tagged with information about the time and anatomical location of development in which they occur.</p> <p>Description</p> <p>We have developed myGRN (<url>http://www.myGRN.org</url>), a web application for storing and interrogating interaction data, with an emphasis on developmental processes. Users can submit interaction and gene expression data, either curated from published sources or derived from their own unpublished data. All interactions associated with publications are publicly visible, and unpublished interactions can only be shared between collaborating labs prior to publication. Users can group interactions into discrete networks based on specific biological processes. Various filters allow dynamic production of network diagrams based on a range of information including tissue location, developmental stage or basic topology. Individual networks can be viewed using myGRV, a tool focused on displaying developmental networks, or exported in a range of formats compatible with third party tools. Networks can also be analysed for the presence of common network motifs. We demonstrate the capabilities of myGRN using a network of zebrafish interactions integrated with expression data from the zebrafish database, ZFIN.</p> <p>Conclusion</p> <p>Here we are launching myGRN as a community-based repository for interaction networks, with a specific focus on developmental networks. We plan to extend its functionality, as well as use it to study networks involved in embryonic development in the future.</p

Constructing a Godly society: the template for a Reformed community in the writings of John Hooper (c.1500-1555).

Ever since John Hooper (c.1500-1555), the future Bishop of Gloucester and Worcester, made his famous stand against wearing vestments that placed him in opposition to the leading English clergy, he has been branded in the history of the English Reformation by many as a renegade and a radical. However, this thesis presents Hooper as one who saw himself as a conformist who sought to create the reformed community he desired within the established political and religious customs of his day. To explore this idea, this thesis examines how Hooper imagined a Protestant community for the kingdom of England or elsewhere. It identifies what Hooper considered to be the sources of God’s authority in the community; how that authority was exercised through officials within the community and through godly laws, strong clerical preaching and a universal commitment to vocation. It examines how the people should respond to leaders who brought the successful introduction of Protestantism to their community. Hooper’s vision was advanced in a series of tracts and letters written in Zurich and shortly after his return to England (1547-1551). They were composed at a time when Hooper enjoyed the greatest freedom to articulate his ideas in the company of his mentor, Heinrich Bullinger (1504-1575), and refined through his tenure as a bishop in the Church of England. The reformed community that Hooper envisioned was one that was dependent upon a strong magistrate but also required the acceptance and participation of its members in fully embracing their own vocation and reform. Hooper strongly affirmed that leaders – both ecclesiastical and civil – had a duty to model their reformation in accordance with God’s Law, the Ten Commandments. He assumed that the people would abide by the authority of the Decalogue and practice the Protestant faith together. He also believed that living in such a community would usher in a period of peace and prosperity. Hooper’s zeal for reform was demonstrated by his belief that the Reformation required wholehearted embrace by everyone, but he was willing to operate within established English traditions, in order to see his Protestant beliefs realised within the community

Ship interactions in arbitrary channels

Thesis (S.B. and S.M.)--Massachusetts Institute of Technology, Dept. of Ocean Engineering, 1998.Includes bibliographical references (p. 95-97).by Brodie James Hynes.S.B.and S.M

Can sponge morphologies act as environmental proxies to biophysical factors in the Great Barrier Reef, Australia?

Sponges play a vital role in the world’s most complex and vulnerable marine ecosystems. Various in situ studies have suggested that sponge morphologies (developed from exposure to a range of biophysical factors) can be considered as ecological indicators to current detrimental environmental changes such as climate change, overfishing, pollution and dredging for coastal development. Regional and long-term taxonomic data on sponges within each geographic range is not always available, especially from the Great Barrier Reef (GBR), due to dearth of sponge research. In this study, to understand large-scale variation and advance sponge research and knowledge, morphological characteristics were adopted as a rapid practical way to identify sponges from photo-transect images of a long-term dataset from the GBR. Biennial surveys were carried out in 2008–2014 from 28 pairs of take and no-take zones of the GBR. To evaluate the temporal changes in sponge morphology and correlation between abiotic factors, remote-sensed data such as chlorophyll a, current, wave height and sea surface temperature (SST) during the survey period were analyzed. Results showed sponges were ubiquitous in all six surveyed locations and their distribution was spatially heterogeneous. Encrusting forms were dominant followed by upright, massive, cups and tabular growth forms. Sponges were more prevalent in Innisfail, Pompey and Townsville compared to Cairns, Swain and Capricorn Bunker. Biennial observations showed greater sponge coverage in 2010 and 2014, especially in the central GBR, which may be related to the geomorphology and habitat of reefs along with its influence by wind and wave action. Also, the aftermath of Cyclone Hamish (2009) and Yasi (2011) would have triggered suspended particulate matter that are beneficial to sponge growth. Geostrophic current showed a weak relationship on encrusting, upright and massive forms, whereas, chl-a, wave height and SST appeared to have no effect on sponge morphology, suggesting sponges may be resilient to adverse conditions in the GBR. Whilst selected sponge morphologies can act as environmental proxies to monitor adverse conditions, further in situ research on other environmental parameters such as turbidity, sedimentation, cyclone, tides are required to bring substantial conclusions on sponge morphologies as ecological indicators

An Investigation into Tetrodotoxin (TTX) Levels Associated with the Red Dorsal Spots in Eastern Newt (Notophthalmus viridescens) Efts and Adults

We investigated the concentration of tetrodotoxin (TTX) in sections of skin containing and lacking red dorsal spots in both Eastern newt (Notophthalmus viridescens) efts and adults. Several other species, such as Pleurodeles waltl and Echinotriton andersoni, have granular glands concentrated in brightly pigmented regions on the dorsum, and thus we hypothesized that the red dorsal spots of Eastern newts may also possess higher levels of TTX than the surrounding skin. We found no difference between the concentrations of TTX in the red spots as compared to neighboring skin lacking these spots in either efts or adults. However, efts with more red dorsal spots had elevated TTX levels relative to efts with fewer spots

The role of the gut microbiome in sustainable teleost aquaculture

As the most diverse vertebrate group and a major component of a growing global aquaculture industry, teleosts continue to attract significant scientific attention. The growth in global aquaculture, driven by declines in wild stocks, has provided additional empirical demand, and thus opportunities, to explore teleost diversity. Among key developments is the recent growth in microbiome exploration, facilitated by advances in high-throughput sequencing technologies. Here, we consider studies on teleost gut microbiomes in the context of sustainable aquaculture, which we have discussed in four themes: diet, immunity, artificial selection and closed-loop systems. We demonstrate the influence aquaculture has had on gut microbiome research, while also providing a road map for the main deterministic forces that influence the gut microbiome, with topical applications to aquaculture. Functional significance is considered within an aquaculture context with reference to impacts on nutrition and immunity. Finally, we identify key knowledge gaps, both methodological and conceptual, and propose promising applications of gut microbiome manipulation to aquaculture, and future priorities in microbiome research. These include insect-based feeds, vaccination, mechanism of pro- and prebiotics, artificial selection on the hologenome, in-water bacteriophages in recirculating aquaculture systems (RAS), physiochemical properties of water and dysbiosis as a biomarker