Generalization of fear-potentiated startle in the presence of auditory cues: a parametric analysis

Intense fear responses observed in trauma-, stressor-, and anxiety-related disorders can be elicited by a wide range of stimuli similar to those that were present during the traumatic event. The present study investigated the experimental utility of fear-potentiated startle paradigms to study this phenomenon, known as stimulus generalization, in healthy volunteers. Fear-potentiated startle refers to a relative increase in the acoustic startle response to a previously neutral stimulus that has been paired with an aversive stimulus. Specifically, in Experiment 1 an auditory pure tone (500 Hz) was used as the conditioned stimulus (CS+) and was reinforced with an unconditioned stimulus (US), an airblast to the larynx. A distinct tone (4000 Hz) was used as the nonreinforced stimulus (CS-) and was never paired with an airblast. Twenty-four hours later subjects underwent Re-training followed by a Generalization test, during which subjects were exposed to a range of generalization stimuli (250, 1000, 2000, 4000, 8000 Hz). In order to further examine the point at which fear no longer generalizes, a follow-up experiment (Experiment 2) was performed where a 4000 Hz pure tone was used as the CS+, and during the Generalization test, 2000 and 8000 Hz were used as generalization stimuli. In both Experiment 1 and 2 there was significant discrimination in US expectancy responses on all stimuli during the Generalization Test, indicating the stimuli were perceptually distinct. In Experiment 1, participants showed similar levels of fear-potentiated startle to the generalization stimuli that were adjacent to the CS+, and discriminated between stimuli that were 2 or more degrees from the CS+. Experiment 2 demonstrated no fear-potentiated startle generalization. The current study is the first to use auditory cues to test generalization of conditioned fear responses; such cues may be especially relevant to combat PTSD where much of the traumatic exposure may involve sounds

Underlining possible effects of Coriolis acceleration in experiments with a Mössbauer source

In recent years it seems that, by measuring the transverse Doppler effect in experiments with a Mössbauer source, we observe a higher blue-shift compared to that provided by the standard relativistic time dilation. If this experimental measure will be officially recognized by the scientific community, we believe that the correct explanation must be sought within Einstein's General Relativity theory. Having this in mind, the aim of this paper is to suggest a possible interpretation of the experimental results. We immediately emphasize that ours is only an idea and does not claim to be certainly the correct explanation in the case in which the experimental data will be confirmed

About the Teaching of the Inertial Field as Maxwell like-type

This paper has a didactic aim. The Einstein General Theory of Relativity is very difficult for undergraduates students and also for graduates who have not followed a course of study in gravitational physics. For example, the calculation of some of its known consequences, such as the gravitational time dilation, requires familiarity with space-time metrics. In this paper, starting with the analogy between the electromagnetic field and the inertial one, we want to analyze, through the Einstein Equivalence Principle (EEP), some simple effect in a fictious gravitational field by using the inertial potentials in analogy with the electromagnetic ones

Analisi Matematica per informatici, Teoria ed esercizi

Il libro si propone come guida didattica allo studio dell’Analisi Matematica, per gli studenti del corso di Laurea in Informatica. Il testo di teoria, ricco di esempi ed esercizi svolti presenti in appendice, è suddiviso in quattordici capitoli principali (ai quali si aggiungono quelli introduttivi e l’appendice) che vanno dalle basi della materia alla Serie di Taylor

Attention bias toward threatening faces in women with PTSD: eye tracking correlates by symptom cluster

Maladaptive patterns of attention to emotional stimuli are a common feature of posttraumatic stress disorder (PTSD), with growing evidence supporting sustained attention to threatening stimuli across trauma samples. However, it remains unclear how different PTSD symptom clusters are associated with attentional bias patterns, particularly in urban civilian settings with high rates of trauma exposure and PTSD. The present study examined associations among these variables in 70 traumatized primarily African American women. PTSD was measured using the Clinician Administered PTSD Scale, and eye tracking was used to measure patterns of attention as participants engaged in an attention bias (dot probe) task to emotional faces; average initial fixation (1 s) and dwell duration (overall time spent looking at emotional face versus neutral face across the 5 s task) were used to assess attention bias patterns toward emotional faces. Women with PTSD showed significantly longer dwell duration toward angry faces than women without PTSD (F = 5.16, p < .05). Bivariate correlation analyses with the PTSD symptom clusters showed a significant association between average initial fixation toward angry faces and higher levels of avoidance symptoms (r = 0.29, p < .05) as well as sustained attention to angry faces and higher levels of re-experiencing symptoms (r = 0.24, p < .05). Using separate linear regression models based on initial significant correlations, we found that PTSD avoidance symptoms were significantly related to average initial fixation toward angry faces (R2∆ = 0.09, p < .05) and PTSD re-experiencing symptoms were significantly related to dwell duration toward angry faces (R2∆ = 0.06, p < .05). These findings contribute to evidence that PTSD is related to both initial vigilance and sustained attention to threat and that certain symptom clusters may either drive or be more impacted by attentional biases, highlighting the benefits of addressing attentional biases within treatment