25 research outputs found

    10 Jahre Bildungsstandards - Tagungsband des AK Grundschule in der GDM 2014

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    In diesem Tagungsband sind die Ergebnisse der Herbsttagung des Arbeitskreises Grundschule in der Gesellschaft fĂŒr Didaktik der Mathematik (GDM) in Tabarz vom 07. bis 09. November 2014 zum Thema „10 Jahre Bildungsstandards – RĂŒckblick und Perspektiven“ dokumentiert. Zehn Jahre nach der Verabschiedung der Bildungsstandards nutzte der Arbeitskreis die Tagung, um aus dem Blickwinkel der Grundschule eine RĂŒckschau vorzunehmen und dabei mögliche Perspektiven herauszuarbeiten. Das Rahmenthema wurde in vier HauptvortrĂ€gen im Plenum diskutiert. ZusĂ€tzlich wurde eine Podiumsdiskussion zum Thema durchgefĂŒhrt. Wie es bereits lange Tradition ist, setzten sich außerdem Arbeitsgruppen zu den klassischen Themenfeldern Arithmetik, Geometrie, Sachrechnen und Daten, Zufall & Wahrscheinlichkeit sowie zu den Bereichen Vorschulische Bildung, Lehren & Forschen mit Neuen Medien in der Primarstufe und Lehrerfortbildung intensiv mit aktuellen Forschungs- und Praxisfragen auseinander.The Proceedings of the 2014 Conference of the Research Group on Primary Mathematics Education (Arbeitskreis Grundschule in der GDM) focus on the 10th anniversary of the ‘Bildungsstandards’. Four invited talks as well as a panel discussion addressed the main theme in plenum. Additionally, workings groups on the research areas arithmetic, geometry, modelling, data & probability, as well as groups on teacher education, ICT, and last not least early mathematics education offered discussions on current research issues

    Multiple Loci Are Associated with White Blood Cell Phenotypes

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    White blood cell (WBC) count is a common clinical measure from complete blood count assays, and it varies widely among healthy individuals. Total WBC count and its constituent subtypes have been shown to be moderately heritable, with the heritability estimates varying across cell types. We studied 19,509 subjects from seven cohorts in a discovery analysis, and 11,823 subjects from ten cohorts for replication analyses, to determine genetic factors influencing variability within the normal hematological range for total WBC count and five WBC subtype measures. Cohort specific data was supplied by the CHARGE, HeamGen, and INGI consortia, as well as independent collaborative studies. We identified and replicated ten associations with total WBC count and five WBC subtypes at seven different genomic loci (total WBC count—6p21 in the HLA region, 17q21 near ORMDL3, and CSF3; neutrophil count—17q21; basophil count- 3p21 near RPN1 and C3orf27; lymphocyte count—6p21, 19p13 at EPS15L1; monocyte count—2q31 at ITGA4, 3q21, 8q24 an intergenic region, 9q31 near EDG2), including three previously reported associations and seven novel associations. To investigate functional relationships among variants contributing to variability in the six WBC traits, we utilized gene expression- and pathways-based analyses. We implemented gene-clustering algorithms to evaluate functional connectivity among implicated loci and showed functional relationships across cell types. Gene expression data from whole blood was utilized to show that significant biological consequences can be extracted from our genome-wide analyses, with effect estimates for significant loci from the meta-analyses being highly corellated with the proximal gene expression. In addition, collaborative efforts between the groups contributing to this study and related studies conducted by the COGENT and RIKEN groups allowed for the examination of effect homogeneity for genome-wide significant associations across populations of diverse ancestral backgrounds

    New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk

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    To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P<5 × 10−8), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk

    Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.

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    Numerous genetic loci have been associated with systolic blood pressure (SBP) and diastolic blood pressure (DBP) in Europeans. We now report genome-wide association studies of pulse pressure (PP) and mean arterial pressure (MAP). In discovery (N = 74,064) and follow-up studies (N = 48,607), we identified at genome-wide significance (P = 2.7 × 10(-8) to P = 2.3 × 10(-13)) four new PP loci (at 4q12 near CHIC2, 7q22.3 near PIK3CG, 8q24.12 in NOV and 11q24.3 near ADAMTS8), two new MAP loci (3p21.31 in MAP4 and 10q25.3 near ADRB1) and one locus associated with both of these traits (2q24.3 near FIGN) that has also recently been associated with SBP in east Asians. For three of the new PP loci, the estimated effect for SBP was opposite of that for DBP, in contrast to the majority of common SBP- and DBP-associated variants, which show concordant effects on both traits. These findings suggest new genetic pathways underlying blood pressure variation, some of which may differentially influence SBP and DBP

    Taking stock after nine years of SINUS at elementary schools in Germany: an evaluation of mathematics-related data within the framework of TIMSS 2011

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    Dieser Beitrag stellt erste Ergebnisse der wissenschaftlichen Begleitforschung zum Programm SINUS an Grundschulen (SGS) vor. Um Dimensionen der Wirksamkeit des Programms zu betrachten, werden mathematische Kompetenzen von SchĂŒlerinnen und SchĂŒlern sowie das Weiterbildungs- und Kooperationsverhalten von MathematiklehrkrĂ€ften an SINUS-Grundschulen analysiert und mit Ergebnissen der fĂŒr Deutschland reprĂ€sentativen Trends in International Mathematics and Science Study (TIMSS) 2011 verglichen. Es wird u. a. deutlich, dass MathematiklehrkrĂ€fte an SINUS-Grundschulen im Vergleich zu den im Rahmen von TIMSS befragten Kolleginnen und Kollegen von Professionalisierungsaspekten berichten, die eng mit dem SINUS-Ansatz einhergehen. Auf SchĂŒlerebene können bei den SchĂŒlerinnen und SchĂŒlern an SINUS-Grundschulen höhere Kompetenzwerte in Mathematik festgestellt werden. (DIPF/Orig.)The authors present first results of the supportive research accompanying the program "SINUS in Elementary School" (German abbreviation: SGS), a program aimed to increase the efficiency of lessons in mathematics and science. In order to investigate the dimensions of the program\u27s efficacy, the mathematical competencies of students as well as the teachers\u27 attitude regarding further education and cooperation at elementary schools working with SINUS were analyzed and compared to the results of the "Trends in International Mathematics and Science Study" (TIMSS) of 2011, which is representative for Germany. It was revealed that math teachers at SINUS elementary schools, in contrast to their colleagues within the framework of TIMSS, report aspects of professionalization that are closely linked to the SINUS approach. On the student level, it could be shown that the students at SINUS elementary schools achieve higher competence values in mathematics. (DIPF/Orig.

    Carbon reduction activism in the UK: lexical creativity and lexical framing in the context of climate change

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    This article examines discourses associated with a new environmental movement, “Carbon Rationing Action Groups” (CRAGs). This case study is intended to contribute to a wider investigation of the emergence of a new type of language used to debate climate change mitigation. Advice on how to reduce one's “carbon footprint,” for example, is provided almost daily. Much of this advice is framed by the use of metaphors and “carbon compounds”—lexical combinations of at least two roots—such as “carbon finance” or “low carbon diet.” The study uses a combination of tools from frame analysis and lexical pragmatics within the general framework of ecolinguistics to compare and contrast language use on the CRAGs' website with press coverage reporting on them. The analysis shows how the use of such lexical carbon compounds enables and facilitates different types of metaphorical frames such as dieting, finance and tax paying, war time rationing, and religious imperatives in the two corpora

    Integration ungesicherter SelbstÀndigkeit in die GRV: Notwendige Weiterentwicklung der Alterssicherung in Bismarck-Tradition?

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    Integrating Uninsured Self-Employment into the German Statutory Pension Insurance: A Necessary Development in Pension Provision following the Bismarckian Tradition?This article examines the possible inclusion of self-employed people into the German statutory pension insurance using AVID 2005 data. The group of self-employed considered here consists of people who are currently not covered by an obligatory pension system during episodes of self-employment and who can, therefore, be presumed to need social protection. Model calculations on the individual level show the conditions under which this extended cover of the statutory pension insurance can lead to an improvement in the old age security for the people concerned. Monthly pension contributions that amount to at least half of the standard contribution („Regelbeitrag“) have to be assumed in order to substantially reduce the risk of future old age poverty

    Calculati ons of gaseous and parti culate emissions from German agriculture 1990 – 2017 : Report on methods and data (RMD) Submission 2019

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    The report at hand (including a comprehensive annex of data) serves as additional document to the National Inventory Report (NIR) on the German green house gas emissions and the Informative Inventory Report (IIR) on the German emissions of air pollutants (especially ammonia). The report documents the calculation methods used in the German agricultural inventory model GAS-EM as well as input data, emission results and uncertainties of the emission reporting submission 2018 for the years 1990 - 2017. In this context the sector Agriculture comprises the emissions from animal husbandry, the use of agricultural soils and anaerobic digestion of energy crops. As required by the guidelines, emissions from activities preceding agriculture, from the use of energy and from land use change are reported elsewhere in the national inventories. The report at hand (including a comprehensive annex of data) serves as additional document to the National Inventory Report (NIR) on the German green house gas emissions and the Informative Inventory Report (IIR) on the German emissions of air pollutants (especially ammonia). The report documents the calculation methods used in the German agricultural inventory model GAS-EM as well as input data, emission results and uncertainties of the emission reporting submission 2018 for the years 1990 - 2017. In this context the sector Agriculture comprises the emissions from animal husbandry, the use of agricultural soils and anaerobic digestion of energy crops. As required by the guidelines, emissions from activities preceding agriculture, from the use of energy and from land use change are reported elsewhere in the national inventories.The report at hand (including a comprehensive annex of data) serves as additional document to the National Inventory Report (NIR) on the German green house gas emissions and the Informative Inventory Report (IIR) on the German emissions of air pollutants (especially ammonia). The report documents the calculation methods used in the German agricultural inventory model GAS-EM as well as input data, emission results and uncertainties of the emission reporting submission 2018 for the years 1990 - 2017. In this context the sector Agriculture comprises the emissions from animal husbandry, the use of agricultural soils and anaerobic digestion of energy crops. As required by the guidelines, emissions from activities preceding agriculture, from the use of energy and from land use change are reported elsewhere in the national inventories. The calculation methods are based in principle on the international guidelines for emission reporting and have been continuingly improved during the past years by the ThĂŒnen Institute working group on agricultural emission inventories, partly in cooperation with KTBL. In particular, these improvements concern the calculation of energy requirements, feeding and the N balance of the most important animal categories. In addition, technical measures such as air scrubbing (mitigation of ammonia emissions) and digestion of animal manures (mitigation of emissions of methane and laughing gas) have been taken into account. For the calculation of emissions from anaerobic digestion of animal manures and energy crops (including spreading of the digestate), the aforementioned working group developed, in cooperation with KTBL, a national methodology
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