Constructing a Learning Community: One Medical Schools Needs Assessment

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Prospectus, March 22, 1984

BARKSTALL TALKS ABOUT DISCRIMINATION; News Digest; This is Karyn\u27s chance: and nothing will stop her!!; Scream and run--best self defense; PC Happenings: Workshop for radiologic technologists, SIU counselor at Parkland, Parkland play to open; Fear, anger, guilt and confusion: Common feelings after rape; StuGo conducting survey; 1984 motorcycle courses; Fall Registration; Did You Know...; The changing face of Women\u27s Lib: Working with and through the system; \u27Harry and Son\u27 warm and touching......; Run--\u27Just for the health of it\u27; Parkland student helps disaster effort; School prayer debate continues; \u27Yes\u27 appears at Assembly Hall; Creative Corner...Especially for you!!: Rain, Window Watching, We begin our lives as tiny..., The sun\u27s golden rays..., Climbing the Mountain, We are alone in this world..., He was only joking..., Used Too, You can\u27t stop rock-\u27n-roll..., The prison of my mind..., I am too younf to feel so worn and tired..., Living hard and fast..., Don\u27t get me wrong..., I can never forget...; Champaign County in the middle of a tornado belt; Tornado prevention; Classifieds; YES concert proves to be big disappointment; Skating projects emotion; \u27Splash\u27 wildly funny entertainment; WILL hosts telecourse; Orioles to repeat; Class A results; Lady Cobras finish third; Cobras eliminated; 1984 Parkland College Baseball Roster; Wet grounds hamper softball; Chargers ready for the Hall; I.M. Newshttps://spark.parkland.edu/prospectus_1984/1028/thumbnail.jp

Electron Correlation Effects in Resonant Inelastic X-ray Scattering of NaV2O5

Element- and site-specific resonant inelastic x-ray scattering spectroscopy (RIXS) is employed to investigate electron correlation effects in {$\rm NaV_2O_5$}. In contrast to single photon techniques, RIXS at the vanadium $L_3$ edge is able to probe $d-d^*$ transitions between V d-bands. A sharp energy loss feature is observed at -1.56 eV, which is well reproduced by a model calculation including correlation effects. The calculation identifies the loss feature as excitation between the lower and upper Hubbard bands and permits an accurate determination of the Hubbard interaction term $U= 3.0 \pm 0.2$ eV.Comment: 15 pages, four figures, accepted to Phys. Rev. Let

Discovery of sarolaner:A novel, Orally administered, broad-spectrum, Isoxazoline ectoparasiticide for dogs

AbstractThe novel isoxazoline ectoparasiticide, sarolaner, was identified during a lead optimization program for an orally-active compound with efficacy against fleas and ticks on dogs. The aim of the discovery program was to identify a novel isoxazoline specifically for use in companion animals, beginning with de novo synthesis in the Zoetis research laboratories. The sarolaner molecule has unique structural features important for its potency and pharmacokinetic (PK) properties, including spiroazetidine and sulfone moieties. The flea and tick activity resides in the chirally pure S-enantiomer, which was purified to alleviate potential off-target effects from the inactive enantiomer. The mechanism of action was established in electrophysiology assays using CHO-K1 cell lines stably expressing cat flea (Ctenocephalides felis) RDL (resistance-to-dieldrin) genes for assessment of GABA-gated chloride channel (GABACls) pharmacology. As expected, sarolaner inhibited GABA-elicited currents at both susceptible (CfRDL-A285) and resistant (CfRDL-S285) flea GABACls with similar potency. Initial whole organism screening was conducted in vitro using a blood feeding assay against C. felis. Compounds which demonstrated robust activity in the flea feed assay were subsequently tested in an in vitro ingestion assay against the soft tick, Ornithodoros turicata. Efficacious compounds which were confirmed safe in rodents at doses up to 30mg/kg were progressed to safety, PK and efficacy studies in dogs. In vitro sarolaner demonstrated an LC80 of 0.3μg/mL against C. felis and an LC100 of 0.003μg/mL against O. turicata. In a head-to-head comparative in vitro assay with both afoxolaner and fluralaner, sarolaner demonstrated superior flea and tick potency. In exploratory safety studies in dogs, sarolaner demonstrated safety in dogs≥8 weeks of age upon repeated monthly dosing at up to 20mg/kg. Sarolaner was rapidly and well absorbed following oral dosing. Time to maximum plasma concentration occurred within the first day post-dose. Bioavailability for sarolaner was calculated at >85% and the compound was highly protein bound (>99.9%). The half-life for sarolaner was calculated at 11–12 days. Sarolaner plasma concentrations indicated dose proportionality over the range 1.25–5mg/kg, and these same doses provided robust efficacy (>99%) for ≥35days against both fleas (C. felis) and multiple species of ticks (Rhipicephalus sanguineus, Ixodes ricinus and Dermacentor reticulatus) after oral administration to dogs. As a result of these exploratory investigations, sarolaner was progressed for development as an oral monthly dose for treatment and control of fleas and ticks on dogs

The Contribution of Dental Amalgam to Urinary Mercury Excretion in Children

BACKGROUND: Urinary mercury concentrations are widely used as a measure of mercury exposure from dental amalgam fillings. No studies have evaluated the relationship of these measures in a longitudinal context in children. OBJECTIVE: We evaluated urinary mercury in children 8–18 years of age in relation to number of amalgam surfaces and time since placement over a 7-year course of amalgam treatment. METHODS: Five hundred seven children, 8–10 years of age at baseline, participated in a clinical trial to evaluate the neurobehavioral effects of dental amalgam in children. Subjects were randomized to either dental amalgam or resin composite treatments. Urinary mercury and creatinine concentrations were measured at baseline and annually on all participants. RESULTS: Treatment groups were comparable in baseline urinary mercury concentration (~ 1.5 μg/L). Mean urinary mercury concentrations in the amalgam group increased to a peak of ~ 3.2 μg/L at year 2 and then declined to baseline levels by year 7 of follow-up. There was a strong, positive association between urinary mercury and both number of amalgam surfaces and time since placement. Girls had significantly higher mean urinary mercury concentrations than boys throughout the course of amalgam treatment. There were no differences by race in urinary mercury concentration associated with amalgam exposure. CONCLUSIONS: Urinary mercury concentrations are highly correlated with both number of amalgam fillings and time since placement in children. Girls excrete significantly higher concentrations of mercury in the urine than boys with comparable treatment, suggesting possible sex-related differences in mercury handling and susceptibility to mercury toxicity.info:eu-repo/semantics/publishedVersio

Prospectus, April 18, 1984

CHORAL UNION DEMANDING AND REWARDING; News Digest; Is your child part of the identi-child program?; Budding playwrights get chance to have work produced; PC Happenings: Parkland wins Automotive Contest, German Club annual Springfest, EMT workshop offered, Petitions available for Stu-Go, Stu-Go lacks quorum; Here Comes the Easter Bunny (or the Easter Hare?); Faces We Make; Former Prospectus entertainment writer: Alender services held; Strange things at the library; Only Food Service Management course in area: Sutton leads Food Service Management program; Criminal justice program well rounded; Running may increase protein need; Easter means Easter egg time; Second Wind hosts race; Did You Know...; Classifieds; Creative Corner...Especially for you!!: Recollections, She\u27s More than a Nurse, You are a corn-fed steak..., Memories..., A fire burns, AKTING??????????????..., Sometimes in their heed to tact..., Clouds, Disturb Not the Dead, Follow the Wind, I don\u27t know why I bother..., Innoncent Eyes, Please tell me what it is you want..., Running scared from yourself and tripped, babe..., Time Bomb, Don\u27t go away--Linger on..., Class, Raggedy Ann lay in the back of an old station wagon..., Too Late, To God; Ice Capades comes to town: Skaters say it\u27s hard work but well worth it; few surprises during Hollywood\u27s biggest night; \u27Queen\u27 film at Assembly Hall; Director shines in film; \u27Go-Go\u27s\u27 are back on track; \u27Weird Al\u27 hits big time; Fan Club to host film; Parkland College 1984 baseball roster; Cobra men lose two; 1984 Parkland Outdoor Track Bests; Sports Digest; Women lose twin bill; Prospectus survey resultshttps://spark.parkland.edu/prospectus_1984/1024/thumbnail.jp

Prospectus, March 7, 1984

CONGRESS RETURNS TO A \u27MOST IMPORTANT\u27 STUDENT AID DEBATE; News Digest; Four paintings stolen from Parkland; \u27Job Training and Partnership Act\u27: JTPA \u27good opportunity for dedicated\u27; PC Happenings: TV programs for busy parents, Parkland announces registration, Polish folk arts at Parkland; Sargent talks to Lifelong Learners\u27 Club; Yaxley scholarship; Stu-Go News; \u27Planned Parenthood\u27--pro choice organization; In the Library--Paperbacks; Nolen enjoys differences; What is Sadie Hawkins Day?; Did You Know...; Scholarship news for real estate students; Tuexdo styles are changing; What did you thinnk of the Grammy Awards?; Classifieds; \u27Good looking coed\u27 hunt draws lots of photos; Urbana construction will increase; Learning to relax can kill stress; \u27Women\u27s History Week\u27 honored; Parkland Christian Fellowship to sponsor conference; Weather conditions force closing; Math contest at Parkland; Financia; aid for summer and fall; The latest in swimwear; \u27Western look\u27 changing; Creative Corner...Especially for you!!: Believe..., Creed, Dream, The End, Darkness...; All Up to Me, Listening to an old..., Father to Son, How to know just what is real..., For Larry, Hi, I\u27m crazy ...; Bite the Bullet, Answer, Why can\u27t we see?, Love sparked nu the heat of summer...,Keg, A low rumble starts..., Oh, Mothers..., Has the human race forgot to look at a sunset..., I tried to play your game..., You\u27ve let me down...; Jackson leads the way at this year\u27s Grammy awards; Dexter--valuable asset; $50,000 and silence \u27cheap way for MSU to avoid lawsuit\u27; In the Library--; Channel 12 fund drive stresses \u27TV worth paying for\u27; Woody Allen\u27s latest hilarious; \u27Foghat\u27 hits C/U March 18; Predictions for the upcoming Academy Awards; \u27Big Country\u27 to appear; \u27Full Metal Jacket\u27 talent search; \u27The Right Stuff\u27 finally opens in area; Energetic movie should do well; Baseball Schedule; Bank president--NFL referee; High School Notes; Softball Schedule; Cobra baseball to start; Women win tournament; Lake Land advances in sectional; Mens basketball scores; I.M. News; Cobra men advance to sectional; Cobras end up with last year\u27s record; Tae Kwon Do showed display; Cooper remembers 6 good years; First basketball coach tells how it was; NJCAA meethttps://spark.parkland.edu/prospectus_1984/1029/thumbnail.jp