South Carolina Department of Transportation and the United States Department of Agriculture, Partnering for Success in Migratory Bird Treaty Act Compliance: A Case Study

The South Carolina Department of Transportation (SCDOT) is responsible for maintaining over 8,400 bridges statewide and several species of migratory birds use these structures as nesting locations. These birds, including their nests and eggs, are protected under the Migratory Bird Treaty Act (MBTA). During a review of MBTA compliance in 2014, SCDOT concluded that they had no procedures in place to allow take to occur when active migratory bird nests were found within project limits. Project delays were the only management method available when active nests were found. SCDOT entered a Cooperative Service Agreement with USDA Wildlife Services (WS) in 2016 to address MBTA compliance on SCDOT projects. The agreement called for WS to manage migratory birds at bridge projects to prevent project delays. WS would repeatedly visit bridge projects, survey the bridges for nests, and remove the nests before they became active. Since 2016, WS has inspected 233 bridges and migratory birds were present at approximately 66% of those bridges with a total of 9,250 inactive nests being removed using a variety of methods. Since the partnership’s inception, construction delays due to migratory birds have been completely avoided with an average cost per project of $1,525. With the passage of a new motor fuel user fee in South Carolina, SCDOT plans to replace 465 bridges over the next 10 years. This increase in work will require continued development and implementation of the partnership to effectively meet the rapidly growing transportation needs while minimizing impacts to species protected under the MBTA

Process Control of Activated Sludge Treatment, Phase II

Material balances on substrate and microorganisms were derived in conjunction with various mixing configurations thought to accurately describe the activated sludge process. These models include the completely mixed with bypass, plug flow, and plug flow with bypass. Two sets of kinetic mechanisms for substrate utilization and bacterial growth were employed. A feed forward controller was designed from linear approximations of the material balances derived in the completely mixed with bypass mixing model. Utilizing frequency response methods, the controller was found essentially identical to a completely mixed modeled controller developed in a prior investigation. Through computer simulation the controller\u27s effectiveness was tested. The controller maintained suitable effluent quality principally through proportional control on the influent flow rate. Additional proportional derivative control on influent substrate concentration produced further reductions in substrate levels; however, when employing realistic forcing functions,these reductions were minor. Comparison of mixing models was dependent upon the degree of substrate loading inflicted on the system. Bypassing had a detrimental effect on effluent quality and process control. Experimental studies were performed to find a representative kinetic and mixing model which reproduces the diurnal fluctuations of key activated sludge process parameters found at the Lexington Wastewater Treatment Plant. A suitable model was not found as experimental and theoretical results did not agree

Process Control of Activated Sludge Treatment

General feed forward controllers, conforming to standard control modes, have been derived for an activated sludge process. The analysis indicated that the appropriate controllers are proportional control with measurement of substrate flow rate, and derivative control with measurement of inlet substrate concentration, and manipulation of the rate of return sludge by both controllers. The performance of these controllers was tested by computer simulation of five dynamic aerator models with and without sludge storage, and with two settling basin models. In all cases significant reduction of the maximum exit substrate concentration was achieved. Additional improvement resulted from the use of sludge storage. As the aerator model became more linear the control results also improved. The first dynamic results were obtained using a perfect steady state settler model, the remainder assumed that the settler dynamics could be represented by a variable time delay. The addition of the settler dynamics caused the control to degrade somewhat. Finally the generality of the two controllers was proved mathematically for the five biological kinetic models for substrate utilization and bacterial growth

Poor caregiver mental health predicts mortality of patients with neurodegenerative disease.

Dementia and other neurodegenerative diseases cause profound declines in functioning; thus, many patients require caregivers for assistance with daily living. Patients differ greatly in how long they live after disease onset, with the nature and severity of the disease playing an important role. Caregiving can also be extremely stressful, and many caregivers experience declines in mental health. In this study, we investigated the role that caregiver mental health plays in patient mortality. In 176 patient-caregiver dyads, we found that worse caregiver mental health predicted greater patient mortality even when accounting for key risk factors in patients (i.e., diagnosis, age, sex, dementia severity, and patient mental health). These findings highlight the importance of caring for caregivers as well as patients when attempting to improve patients' lives

Age Differences in Interhemispheric Interactions: Callosal Structure, Physiological Function, and Behavior

There is a fundamental gap in understanding how brain structural and functional network connectivity are interrelated, how they change with age, and how such changes contribute to older adults’ sensorimotor deficits. Recent neuroimaging approaches including resting state functional connectivity MRI (fcMRI) and diffusion tensor imaging (DTI) have been used to assess brain functional (fcMRI) and structural (DTI) network connectivity, allowing for more integrative assessments of distributed neural systems than in the past. Declines in corpus callosum size and microstructure with advancing age have been well documented, but their contributions to age deficits in unimanual and bimanual function are not well defined. Our recent work implicates age-related declines in callosal size and integrity as a key contributor to unimanual and bimanual control deficits. Moreover, our data provide evidence for a fundamental shift in the balance of excitatory and inhibitory interhemispheric processes that occurs with age, resulting in age differences in the relationship between functional and structural network connectivity. Training studies suggest that the balance of interhemispheric interactions can be shifted with experience, making this a viable target for future interventions

A Pilot Online Survey Assessing Risk Factors for HIV Acquisition in the Navy and Marine Corps, 2005-2010

The Department of Defense policy Don\u27t Ask, Don\u27t Tell (DADT) ended in September, 2011. The Navy Bloodborne Infection Management Center conducted a post-DADT pilot survey of HIV seroconverters identified when the DADT policy was in effect. Sailors and Marines newly diagnosed as HIV positive from 2005 to 2010 were invited to participate in an online survey. A structured questionnaire elicited risk information about the 3-year period before HIV diagnosis. Respondents reported engaging commonly in same sex sexual activity, having concurrent partners, and poor condom use for anal sex. In this first post-DADT repeal report of self-reported behaviors, male-to-male sexual contact was a much more common mode of infection than previously reported. Several opportunities for primary prevention messaging now possible after DADT repeal are evident

LONP1 and mtHSP70 cooperate to promote mitochondrial protein folding

Most mitochondrial precursor polypeptides are imported from the cytosol into the mitochondrion, where they must efficiently undergo folding. Mitochondrial precursors are imported as unfolded polypeptides. For proteins of the mitochondrial matrix and inner membrane, two separate chaperone systems, HSP60 and mitochondrial HSP70 (mtHSP70), facilitate protein folding. We show that LONP1, an AAA+ protease of the mitochondrial matrix, works with the mtHSP70 chaperone system to promote mitochondrial protein folding. Inhibition of LONP1 results in aggregation of a protein subset similar to that caused by knockdown of DNAJA3, a co-chaperone of mtHSP70. LONP1 is required for DNAJA3 and mtHSP70 solubility, and its ATPase, but not its protease activity, is required for this function. In vitro, LONP1 shows an intrinsic chaperone-like activity and collaborates with mtHSP70 to stabilize a folding intermediate of OXA1L. Our results identify LONP1 as a critical factor in the mtHSP70 folding pathway and demonstrate its proposed chaperone activity

Tethered capsule endomicroscopy enables less-invasive imaging of gastrointestinal tract microstructure

Here, we introduce “tethered capsule endomicroscopy,” that involves swallowing an optomechanically-engineered pill that captures cross-sectional, 30 μm (lateral) × 7 μm (axial) resolution, microscopic images of the gut wall as it travels through the digestive tract. Results in human subjects show that this technique rapidly provides three-dimensional, microstructural images of the upper gastrointestinal tract in a simple and painless procedure, opening up new opportunities for screening for internal diseases