120 research outputs found
Association polymorphism CSFM50 with weight gain in Hereford beef cattle.
Este foi o tĂtulo do artigo submetido ao Congresso "Association of microsatellite CSFM50 with weaning weight in Hereford beef cattle", mas este foi o tĂtulo publicado no Proceedings
Many-body perturbation calculation of spherical nuclei with a separable monopole interaction: I. Finite nuclei
We present calculations of ground state properties of spherical, doubly
closed-shell nuclei from O to Pb employing the techniques of
many-body perturbation theory using a separable density dependent monopole
interaction. The model gives results in Hartree-Fock order which are of similar
quality to other effective density-dependent interactions. In addition, second
and third order perturbation corrections to the binding energy are calculated
and are found to contribute small, but non-negligible corrections beyond the
mean-field result. The perturbation series converges quickly, suggesting that
this method may be used to calculate fully correlated wavefunctions with only
second or third order perturbation theory. We discuss the quality of the
results and suggest possible methods of improvement.Comment: 20 Pages, 11 figure
A randomised phase II trial of Stereotactic Ablative Fractionated radiotherapy versus Radiosurgery for Oligometastatic Neoplasia to the lung (TROG 13.01 SAFRON II)
© 2016 Siva et al. Background: Stereotactic ablative body radiotherapy (SABR) is emerging as a non-invasive method for precision irradiation of lung tumours. However, the ideal dose/fractionation schedule is not yet known. The primary purpose of this study is to assess safety and efficacy profile of single and multi-fraction SABR in the context of pulmonary oligometastases. Methods/Design: The TROG 13.01/ALTG 13.001 clinical trial is a multicentre unblinded randomised phase II study. Eligible patients have up to three metastases to the lung from any non-haematological malignancy, each<5cm in size, non-central targets, and have all primary and extrathoracic disease controlled with local therapies. Patients are randomised 1:1 to a single fraction of 28Gy versus 48Gy in four fractions of SABR. The primary objective is to assess the safety of each treatment arm, with secondary objectives including assessment of quality of life, local efficacy, resource use and costs, overall and disease free survival and time to distant failure. Outcomes will be stratified by number of metastases and origin of the primary disease (colorectal versus non-colorectal primary). Planned substudies include an assessment of the impact of online e-Learning platforms for lung SABR and assessment of the effect of SABR fractionation on the immune responses. A total of 84 patients are required to complete the study. Discussion: Fractionation schedules have not yet been investigated in a randomised fashion in the setting of oligometastatic disease. Assuming the likelihood of similar clinical efficacy in both arms, the present study design allows for exploration of the hypothesis that cost implications of managing potentially increased toxicities from single fraction SABR will be outweighed by costs associated with delivering multiple-fraction SABR. Trials registration:ACTRN12613001157763 , registered 17th October 201
Medial Orbitofrontal Cortex Regulates Instrumental Conditioned Punishment, but not Pavlovian Conditioned Fear
Abstract
Bidirectionally aberrant medial orbitofrontal cortical (mOFC) activity has been consistently linked with compulsive disorders and related behaviors. Although rodent studies have established a causal link between mOFC excitation and compulsive-like actions, no such link has been made with mOFC inhibition. Here we use excitotoxic lesions of mOFC to investigate its role in sensitivity to punishment; a core characteristic of many compulsive disorders. In our first experiment, we demonstrated that mOFC lesions prevented rats from learning to avoid a lever that was punished with a stimulus that co-terminated with footshock. Our second experiment demonstrated that retrieval of punishment learning is also somewhat mOFC-dependent, as lesions prevented the extended retrieval of punishment contingencies relative to shams. In contrast, mOFC lesions did not prevent rats from re-acquiring the ability to avoid a punished lever when it was learned prior to lesions being administered. In both experiments, Pavlovian fear conditioning to the stimulus was intact for all animals. Together, these results reveal that the mOFC regulates punishment learning and retrieval in a manner that is separate from any role in Pavlovian fear conditioning. These results imply that aberrant mOFC activity may contribute to the punishment insensitivity that is observed across multiple compulsive disorders.</jats:p
An analysis of respiratory induced kidney motion on four-dimensional computed tomography and its implications for stereotactic kidney radiotherapy
The influence of oblique-angle forced exercise in surgically destabilized stifle joints is synergistic with bone, but antagonistic with cartilage in an ovine model of osteoarthritis
Large animal models of osteoarthritis are a necessary testing ground for FDA approval of human medicine applications. Sheep models have advantages over other available large animals, but development and progression of osteoarthritis in sheep is exceedingly slow, which handicaps progress in development of potential treatments. We combined oblique angle forced exercise to increase stress on the stifle, with surgical destabilization to hasten the development of osteoarthritis in ewes. Methods for early detection of clinical signs included radiography, urine, and serum biomarker assays and gait analysis and ex vivo we used microcomputed tomography and macroscopic joint analysis. Our model was able to produce clinically detectable signs of osteoarthritis in a relatively short period (14 weeks). Changes in bone were highly correlated between microcomputed tomography and radiographic analysis and changes in cartilage correlated well between urinary glycosaminoglycan levels and serum aggrecanase analyses. Exercise improved the negative effects of destabilization in bone but exacerbated the negative effects of destabilization in cartilage. These observations suggest that we may need to consider treatments for bone and cartilage separately. These results represent an improved large animal model of osteoarthritis with rapid onset of disease and superior detection of bone and soft tissue changes
Nucleon-Nucleon Interaction: A Typical/Concise Review
Nearly a recent century of work is divided to Nucleon-Nucleon (NN)
interaction issue. We review some overall perspectives of NN interaction with a
brief discussion about deuteron, general structure and symmetries of NN
Lagrangian as well as equations of motion and solutions. Meanwhile, the main NN
interaction models, as frameworks to build NN potentials, are reviewed
concisely. We try to include and study almost all well-known potentials in a
similar way, discuss more on various commonly used plain forms for two-nucleon
interaction with an emphasis on the phenomenological and meson-exchange
potentials as well as the constituent-quark potentials and new ones based on
chiral effective field theory and working in coordinate-space mostly. The
potentials are constructed in a way that fit NN scattering data, phase shifts,
and are also compared in this way usually. An extra goal of this study is to
start comparing various potentials forms in a unified manner. So, we also
comment on the advantages and disadvantages of the models and potentials partly
with reference to some relevant works and probable future studies.Comment: 85 pages, 5 figures, than the previous v3 edition, minor changes, and
typos fixe
Regioisomeric and substituent effects upon the outcome of the reaction of 1-borodienes with nitrosoarene compounds
A study of the reactivity of 1-borodienes with nitrosoarene compounds has been carried out showing an outcome that differs according to the hybridization state of the boron moiety. Using an sp2 boron substituent, a one-pot hetero-Diels–Alder/ring contraction cascade occurred to afford N-arylpyrroles with low to good yields depending on the electronic properties of the substituents on the borodiene, whereas an sp3 boron substituent led to the formation of stable boro-oxazines with high regioselectivity in most of the cases, in moderate to good yields. 1H and 11B NMR studies on two boro-oxazine regioisomers showed that selective deprotection can be performed. Formation of either the pyrrole or the furan derivative is pH- and regioisomer-structure-dependent. The results obtained, together with previous B3LYP calculations, support mechanistic proposals which suggest that pyrrole, or furan, formation proceeds via oxazine formation, followed by a boryl rearrangement and an intramolecular addition–elimination sequence
Quantum cascade laser frequency stabilisation at the sub-Hz level
Quantum Cascade Lasers (QCL) are increasingly being used to probe the
mid-infrared "molecular fingerprint" region. This prompted efforts towards
improving their spectral performance, in order to reach ever-higher resolution
and precision. Here, we report the stabilisation of a QCL onto an optical
frequency comb. We demonstrate a relative stability and accuracy of 2x10-15 and
10-14, respectively. The comb is stabilised to a remote near-infrared
ultra-stable laser referenced to frequency primary standards, whose signal is
transferred via an optical fibre link. The stability and frequency traceability
of our QCL exceed those demonstrated so far by two orders of magnitude. As a
demonstration of its capability, we then use it to perform high-resolution
molecular spectroscopy. We measure absorption frequencies with an 8x10-13
relative uncertainty. This confirms the potential of this setup for ultra-high
precision measurements with molecules, such as our ongoing effort towards
testing the parity symmetry by probing chiral species
Static, dynamic balance and functional performance in subjects with and without plantar fasciitis
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