Análise citogenética de híbridos entre Triticum durum x Aegilops tauschii com potencial uso em programas de melhoramento genético de trigo.

Editores técnicos: Joseani Mesquita Antunes, Ana Lídia Variani Bonato, Márcia Barrocas Moreira Pimentel

Pooled analysis of cardiac safety in patients with cancer treated with pertuzumab

Background: Pertuzumab, a human epidermal growth factor receptor (HER) 2 dimerization inhibitor, has demonstrated promising efficacy in combination with trastuzumab in patients with metastatic breast cancer. As HER signaling pathways are not only involved in oncogenesis, but also in myocardial homeostasis, an analysis of cardiac safety data was undertaken in a large group of patients treated with pertuzumab. Patients and methods: A complete database of patients treated with full-dose pertuzumab was used to describe the incidence of asymptomatic left ventricular systolic dysfunction (LVSD) and symptomatic heart failure (HF). Results: Information for 598 unique patients was available for the current analysis. Of the patients treated with pertuzumab alone (n = 331) or pertuzumab in combination with a non-anthracycline-containing cytotoxic (n = 175) or trastuzumab (n = 93), 23 (6.9%), 6 (3.4%), and 6 (6.5%), respectively, developed asymptomatic LVSD and 1 (0.3%), 2 (1.1%), and 1 (1.1%), respectively, displayed symptomatic HF. None of the 15 patients receiving both pertuzumab and erlotinib demonstrated LVSD. Conclusions: Patients treated with pertuzumab experienced relatively low levels of asymptomatic LVSD or symptomatic HF. There was no notable increase in cardiac side-effects when pertuzumab was given in combination with other anticancer agent

On the controllability of bimodal piecewise linear systems

This paper studies controllability of bimodal systems that consist of two linear dynamics on each side of a given hyperplane. We show that the controllability properties of these systems can be inferred from those of linear systems for which the inputs are constrained in a certain way. Inspired by the earlier work on constrained controllability of linear systems, we derive necessary and sufficient conditions for a bimodal piecewise linear system to be controllable.Natl Sci Fdn; Univ Penn, Sch Engn & Appl Sci

Probing dark matter substructure in the gravitational lens HE0435-1223 with the WFC3 grism

Strong gravitational lensing provides a powerful test of Cold Dark Matter (CDM) as it enables the detection and mass measurement of low mass haloes even if they do not contain baryons. Compact lensed sources such as Active Galactic Nuclei (AGN) are particularly sensitive to perturbing subhalos, but their use as a test of CDM has been limited by the small number of systems which have significant radio emission which is extended enough avoid significant lensing by stars in the plane of the lens galaxy, and red enough to be minimally affected by differential dust extinction. Narrow-line emission is a promising alternative as it is also extended and, unlike radio, detectable in virtually all optically selected AGN lenses. We present first results from a WFC3 grism narrow-line survey of lensed quasars, for the quadruply lensed AGN HE0435-1223. Using a forward modelling pipeline which enables us to robustly account for spatial blending, we measure the [OIII] 5007 \AA~ flux ratios of the four images. We find that the [OIII] fluxes and positions are well fit by a simple smooth mass model for the main lens. Our data rule out a $M_{600}>10^{8} (10^{7.2}) M_\odot$ NFW perturber projected within $\sim$1\farcs0 (0\farcs1) arcseconds of each of the lensed images, where $M_{600}$ is the perturber mass within its central 600 pc. The non-detection is broadly consistent with the expectations of $\Lambda$CDM for a single system. The sensitivity achieved demonstrates that powerful limits on the nature of dark matter can be obtained with the analysis of $\sim20$ narrow-line lenses.Comment: Accepted for publication in MNRAS, 15 pages, 8 figure

MIPS 24 Micron Observations of the Hubble Deep Field South: Probing the IR-Radio Correlation of Galaxies at z > 1

We present MIPS 24 micron observations of the Hubble Deep Field South taken with the Spitzer Space Telescope. The resulting image is 254 arcmin^2 in size and has a sensitivity ranging between ~12 to ~30 microJy rms, with a median sensitivity of ~20 microJy rms. A total of 495 sources have been cataloged with a signal-to-noise ratio greater than 5 sigma. The source catalog is presented as well as source counts which have been corrected for completeness and flux boosting. The IR sources are then combined with MUSYC optical/NIR and ATHDFS radio observations to obtain redshifts and radio flux densities of the sample. We use the IR/radio flux density ratio (q_24) to explore the IR-radio correlation for this IR sample and find q_24 = 0.71 +- 0.31 for sources detected in both IR and radio. The results are extended by stacking IR sources not detected in the radio observations and we derive an average q_24 for redshift bins between 0 1) sources have an average q_{24} ratio which is better fit by local LIRG SEDs rather than local ULIRG SEDs, indicating that high redshift ULIRGs differ in their IR/radio properties. So ULIRGs at high redshift have SEDs different from those found locally. Infrared faint radio sources are examined, and while nine radio sources do not have a MIPS detection and are therefore radio-loud AGN, only one radio source has an extreme IRAC 3.6 micron to radio flux density ratio indicating it is a radio-loud AGN at z > 1.Comment: 11 pages, 8 figures, accepted for publication in Ap

The Grism Lens-Amplified Survey from Space (GLASS). XII. Spatially Resolved Galaxy Star Formation Histories and True Evolutionary Paths at z > 1

Modern data empower observers to describe galaxies as the spatially and biographically complex objects they are. We illustrate this through case studies of four, $z\sim1.3$ systems based on deep, spatially resolved, 17-band + G102 + G141 Hubble Space Telescope grism spectrophotometry. Using full spectrum rest-UV/-optical continuum fitting, we characterize these galaxies' observed $\sim$kpc-scale structures and star formation rates (SFRs) and reconstruct their history over the age of the universe. The sample's diversity---passive to vigorously starforming; stellar masses $\log M_*/M_\odot=10.5$ to $11.2$---enables us to draw spatio-temporal inferences relevant to key areas of parameter space (Milky Way- to super-Andromeda-mass progenitors). Specifically, we find signs that bulge mass-fractions ($B/T$) and SF history shapes/spatial uniformity are linked, such that higher $B/T$s correlate with "inside-out growth" and central specific SFRs that peaked above the global average for all starforming galaxies at that epoch. Conversely, the system with the lowest $B/T$ had a flat, spatially uniform SFH with normal peak activity. Both findings are consistent with models positing a feedback-driven connection between bulge formation and the switch from rising to falling SFRs ("quenching"). While sample size forces this conclusion to remain tentative, this work provides a proof-of-concept for future efforts to refine or refute it: JWST, WFIRST, and the 30-m class telescopes will routinely produce data amenable to this and more sophisticated analyses. These samples---spanning representative mass, redshift, SFR, and environmental regimes---will be ripe for converting into thousands of sub-galactic-scale empirical windows on what individual systems actually looked like in the past, ushering in a new dialog between observation and theory.Comment: 18 pp, 15 figs, 3 tables (main text); 5 pp, 5 figs, 1 table (appendix); Submitted to AAS Journals 1 October 201

Neural responses to facial and vocal expressions of fear and disgust

Neuropsychological studies report more impaired responses to facial expressions of fear than disgust in people with amygdala lesions, and vice versa in people with Huntington's disease. Experiments using functional magnetic resonance imaging (fMRI) have confirmed the role of the amygdala in the response to fearful faces and have implicated the anterior insula in the response to facial expressions of disgust. We used fMRI to extend these studies to the perception of fear and disgust from both facial and vocal expressions. Consistent with neuropsychological findings, both types of fearful stimuli activated the amygdala. Facial expressions of disgust activated the anterior insula and the caudate-putamen; vocal expressions of disgust did not significantly activate either of these regions. All four types of stimuli activated the superior temporal gyrus. Our findings therefore (i) support the differential localization of the neural substrates of fear and disgust; (ii) confirm the involvement of the amygdala in the emotion of fear, whether evoked by facial or vocal expressions; (iii) confirm the involvement of the anterior insula and the striatum in reactions to facial expressions of disgust; and (iv) suggest a possible general role for the perception of emotional expressions for the superior temporal gyrus

EAZY: A Fast, Public Photometric Redshift Code

We describe a new program for determining photometric redshifts, dubbed EAZY. The program is optimized for cases where spectroscopic redshifts are not available, or only available for a biased subset of the galaxies. The code combines features from various existing codes: it can fit linear combinations of templates, it includes optional flux- and redshift-based priors, and its user interface is modeled on the popular HYPERZ code. A novel feature is that the default template set, as well as the default functional forms of the priors, are not based on (usually highly biased) spectroscopic samples, but on semi-analytical models. Furthermore, template mismatch is addressed by a novel rest-frame template error function. This function gives different wavelength regions different weights, and ensures that the formal redshift uncertainties are realistic. We introduce a redshift quality parameter, Q_z, that provides a robust estimate of the reliability of the photometric redshift estimate. Despite the fact that EAZY is not "trained" on spectroscopic samples, the code (with default parameters) performs very well on existing public datasets. For K-selected samples in CDF-South and other deep fields we find a 1-sigma scatter in dz/(1+z) of 0.034, and we provide updated photometric redshift catalogs for the FIRES, MUSYC, and FIREWORKS surveys.Comment: Accepted for publication in the Astrophysical Journal. 13 pages, 11 figures. Code available at http://www.astro.yale.edu/eazy

Through the looking GLASS: HST spectroscopy of faint galaxies lensed by the Frontier Fields cluster MACS0717.5+3745

The Grism Lens-Amplified Survey from Space (GLASS) is a Hubble Space Telescope (HST) Large Program, which will obtain 140 orbits of grism spectroscopy of the core and infall regions of 10 galaxy clusters, selected to be among the very best cosmic telescopes. Extensive HST imaging is available from many sources including the CLASH and Frontier Fields programs. We introduce the survey by analyzing spectra of faint multiply-imaged galaxies and $z\gtrsim6$ galaxy candidates obtained from the first seven orbits out of fourteen targeting the core of the Frontier Fields cluster MACS0717.5+3745. Using the G102 and G141 grisms to cover the wavelength range 0.8-1.7$\mu$m, we confirm 4 strongly lensed systems by detecting emission lines in each of the images. For the 9 $z\gtrsim6$ galaxy candidates clear from contamination, we do not detect any emission lines down to a seven-orbit 1$\sigma$ noise level of $\sim$5$\times$10$^{-18}$erg s$^{-1}$cm$^{-2}$. Taking lensing magnification into account, our flux sensitivity reaches $\sim$0.2-5$\times$10$^{-18}$erg s$^{-1}$cm$^{-2}$. These limits over an uninterrupted wavelength range rule out the possibility that the high-$z$ galaxy candidates are instead strong line emitters at lower redshift. These results show that by means of careful modeling of the background - and with the assistance of lensing magnification - interesting flux limits can be reached for large numbers of objects, avoiding pre-selection and the wavelength restrictions inherent to ground-based multi-slit spectroscopy. These observations confirm the power of slitless HST spectroscopy even in fields as crowded as a cluster core.Comment: Accepted by ApJ letters, 8 pages, 4 figures, GLASS website at http://glass.physics.ucsb.ed