Higgs boson search significance deformations due to mixed-in scalars

The existence of exotic scalars that mix with the Standard Model (SM) Higgs boson can affect Higgs boson phenomenology in a multitude of ways. We consider two light Higgs bosons with shared couplings to SM fields and with masses close to each other, in the range where the h \to WW \to l \nu l \nu is an important search channel. In this channel, we do not find the dilution of significance of the `SM-like' Higgs boson that is naively expected because of the mixing. This is because of leakage of events from the decay of the other scalar into its signal region. Nevertheless, we show that the broadening of the h\to WW \to l \nu l \nu significance plots of Standard Model Higgs boson searches could indicate the first evidence of the the extra scalar state.Comment: 6 pages, 6 figures; v2: all plots now made with the lighter Higgs mass equal to 125 GeV and other minor corrections made, to be published in Physics Letters

Liquid-like behaviour of gold nanowire bridges

A combination of Focused Ion Beam (FIB) and Reactive Ion Etch (RIE) was used to fabricate free standing gold nanowire bridges with radii of 30 nm and below. These were subjected to point loading to failure at their mid-points using an Atomic Force Microscope (AFM), providing strength and deformation data. The results demonstrate a dimensionally dependent transition from conventional solid metallic properties to liquid-like behaviour including the unexpected reformation of a fractured bridge. The work reveals mechanical and materials properties of nanowires which could have significant impact on nanofabrication processes and nanotechnology devices such as Nano Electro Mechanical Systems (NEMS)

Oliveros Virus: A Novel Arenavirus from Argentina

AbstractDuring the past few decades several newly recognized rodent-borne arenaviruses have been shown to be associated with severe hemorrhagic fever cases in South America. Changes in ecology and farming practices throughout the region have increased the concern over the potential public health threat posed by such emerging virus diseases. Oliveros (OLV) virus is a recently discovered arenavirus of the rodentBolomys obscurusin Argentina. Genetic analysis of the small genomic RNA segment, which encodes the nucleocapsid protein and the envelope glycoproteins, shows that Oliveros is a novel, phylogenetically distinct member of theArenaviridaefamily which differs in nucleotide sequence from the previously characterized members by approximately 35% or more. Despite this level of diversity, OLV virus possesses the same ambisense genome structure and many overall RNA and protein features in common with other arenaviruses. These data represent an important first step in the development of specific immunological and PCR diagnostic reagents to allow assessment of the prevalence and disease potential of this virus

Self-assembling fluorescent hydrogel for highly efficient water purification and photothermal conversion

Employing fluorescent hydrogels for hazardous Hg(II) detection and removal is an efficient method for water purification. However, it remains challenging to establish a fluorescent system with low detection limit and high adsorption capacity that can readily be upcycled into a valuable material resource. Herein, we report on a fluorescent hydrogel with 0D sulfydryl-based carbon dots that are self-assembled with a 3D hydrogel network. The cellulose-based hydrogel exhibited good sensitivity for the detection of Hg(II) over a range from 0 to 40 µM with a limit detection of 3.0 × 10-6 M. The adsorption experiments confirmed that the cellulose-based hydrogel exhibits good Hg(II) extraction capacity of over 662.25 mg g−1 at room temperature, and can effectively reduce the Hg concentration to attain acceptable levels that comply with industrial water standards (0.05 mg L-1). Subsequently, we used a facile strategy to convert the exhausted waste adsorbent by in-situ sulfurization into a suitable material for solar steam generation. The as-prepared upcycled aerogel evaporators exhibited excellent evaporation rates of ∼ 1.30 kg m−2 h−1 under one sun irradiation. These results not only provide a strategy for heavy metal ion recognition and adsorption, but also provide a route to recycle hazardous waste for seawater desalination.</p

Forefoot pathology in rheumatoid arthritis identified with ultrasound may not localise to areas of highest pressure: cohort observations at baseline and twelve months

BackgroundPlantar pressures are commonly used as clinical measures, especially to determine optimum foot orthotic design. In rheumatoid arthritis (RA) high plantar foot pressures have been linked to metatarsophalangeal (MTP) joint radiological erosion scores. However, the sensitivity of foot pressure measurement to soft tissue pathology within the foot is unknown. The aim of this study was to observe plantar foot pressures and forefoot soft tissue pathology in patients who have RA.Methods A total of 114 patients with established RA (1987 ACR criteria) and 50 healthy volunteers were assessed at baseline. All RA participants returned for reassessment at twelve months. Interface foot-shoe plantar pressures were recorded using an F-Scan® system. The presence of forefoot soft tissue pathology was assessed using a DIASUS musculoskeletal ultrasound (US) system. Chi-square analyses and independent t-tests were used to determine statistical differences between baseline and twelve months. Pearson’s correlation coefficient was used to determine interrelationships between soft tissue pathology and foot pressures.ResultsAt baseline, RA patients had a significantly higher peak foot pressures compared to healthy participants and peak pressures were located in the medial aspect of the forefoot in both groups. In contrast, RA participants had US detectable soft tissue pathology in the lateral aspect of the forefoot. Analysis of person specific data suggests that there are considerable variations over time with more than half the RA cohort having unstable presence of US detectable forefoot soft tissue pathology. Findings also indicated that, over time, changes in US detectable soft tissue pathology are out of phase with changes in foot-shoe interface pressures both temporally and spatially.Conclusions We found that US detectable forefoot soft tissue pathology may be unrelated to peak forefoot pressures and suggest that patients with RA may biomechanically adapt to soft tissue forefoot pathology. In addition, we have observed that, in patients with RA, interface foot-shoe pressures and the presence of US detectable forefoot pathology may vary substantially over time. This has implications for clinical strategies that aim to offload peak plantar pressures

Bear Canyon Virus: An Arenavirus Naturally Associated with the California Mouse (Peromyscus californicus)

Thirty-four rodents captured in southern California were studied to increase our knowledge of the arenaviruses indigenous to the western United States. An infectious arenavirus was isolated from 5 of 27 California mice but none of the 7 other rodents. Analyses of viral nucleocapsid protein gene sequence data indicated that the isolates from the California mice are strains of a novel Tacaribe serocomplex virus (proposed name “Bear Canyon”) that is phylogenetically most closely related to Whitewater Arroyo and Tamiami viruses, the only other Tacaribe serocomplex viruses known to occur in North America. The discovery of Bear Canyon virus is the first unequivocal evidence that the virus family Arenaviridae is naturally associated with the rodent genus Peromyscus and that a Tacaribe serocomplex virus occurs in California

Amphiphilic engineering of reduced graphene oxides using a carbon nitride coating for superior removal of organic pollutants from wastewater

Amphiphilic carbon nitride (g-C3N4) was decorated onto reduced graphene oxide (rGO) to obtain rGO-g-C3N4 composites as excellent adsorbents for the removal of aromatic organic compounds from industrial wastewater. The as obtained rGO-g-C3N4 composites are effective adsorbents for organic compounds due to the amphiphilic g-C3N4. We propose a new adsorption model using an amphiphilic additive which can enhance the water accessibility and hydrophobic interactions between rGO with organic compounds in aqueous media. Where, even water-soluble organic molecules like rhodamine B (RhB) have a high adsorption capability for the rGO-g-C3N4 (520 mg g−1). Molecular dynamics simulations were used to investigate the interactions between RhB and rGO-g-C3N4 and indicated that amphiphilic g-C3N4 accelerates the adsorption process. In addition, the amphipathic adsorption approach is enhanced as the salinity of water increases, which can offer great operational flexibility and versatility. This research demonstrates that the highly efficient interactions between aromatic organic molecules and amphiphilic carbon-based nanomaterials can be used for practical applications.</p

Relapse Recovery in Relapsing-Remitting Multiple Sclerosis: An Analysis of the CombiRx Dataset

BACKGROUND: Clinical relapses are the defining feature of relapsing forms of multiple sclerosis (MS), but relatively little is known about the time course of relapse recovery. OBJECTIVE: The aim of this study was to investigate the time course of and patient factors associated with the speed and success of relapse recovery in people with relapsing-remitting MS (RRMS). METHODS: Using data from CombiRx, a large RRMS trial (clinicaltrials.gov identifier NCT00211887), we measured the time to recovery from the first on-trial relapse. We used Kaplan-Meier survival analyses and Cox regression models to investigate the association of patient factors with the time to unconfirmed and confirmed relapse recovery. RESULTS: CombiRx included 1008 participants. We investigated 240 relapses. Median time to relapse recovery was 111 days. Most recovery events took place within 1 year of relapse onset: 202 of 240 (84%) individuals recovered during follow-up, 161 of 202 (80%) by 180 days, and 189 of 202 (94%) by 365 days. Relapse severity was the only factor associated with relapse recovery. CONCLUSION: Recovery from relapses takes place up to approximately 1 year after the event. Relapse severity, but no other patient factors, was associated with the speed of relapse recovery. Our findings inform clinical practice and trial design in RRMS