Expansion du pin d'Alep. Rôle des processus allélopathiques dans la dynamique successionnelle.

L'objet de cet article est de montrer quel peut être le rôle des processus allélopathiques dans le cas d'espèces ligneuses constituant des éléments majeurs des successions secondaires en région méditerranéenne. Les études confirment les propriétés allélopathiques du pin d'Alep, propriétés qu'il faut nuancer en fonction des stades dynamiques et en fonction des sources d'allélochimiques (pluviolessivats ou exsudats racinaires). Enfin la mise en évidence de phénomènes d'autotoxicité amène une réflexion sur les régulations de la dynamique populationnelle de ce pin et sur ses conséquences sur la succession végétale

Integrability as a consequence of discrete holomorphicity: the Z_N model

It has recently been established that imposing the condition of discrete holomorphicity on a lattice parafermionic observable leads to the critical Boltzmann weights in a number of lattice models. Remarkably, the solutions of these linear equations also solve the Yang-Baxter equations. We extend this analysis for the Z_N model by explicitly considering the condition of discrete holomorphicity on two and three adjacent rhombi. For two rhombi this leads to a quadratic equation in the Boltzmann weights and for three rhombi a cubic equation. The two-rhombus equation implies the inversion relations. The star-triangle relation follows from the three-rhombus equation. We also show that these weights are self-dual as a consequence of discrete holomorphicity.Comment: 11 pages, 7 figures, some clarifications and a reference adde

Predicted efficacy and tolerance of different dosage regimens of benzylpenicillin in horses based on a pharmacokinetic study with three IM formulations and one IV formulation

IntroductionBenzylpenicillin (BP) is a first-line antibiotic in horses but there are discrepancies between manufacturers and literature recommendations regarding dosing regimen. Objectives of this study were to evaluate pharmacokinetics and local tolerance of four different formulations of BP in adult horses, and to suggest optimized dosing regimen according to the formulation.MethodsA cross-over design was used in 3 phases for the intramuscular injection of three different products: procaine BP alone, procaine BP/ benzathine BP combination or penethamate hydriodide were administered IM in the gluteal muscles of 6 horses for 3 days. Single IV administration of sodium BP was performed to the same horses with a dose of 22,000 IU BP/kg bwt 39 weeks after last IM injection. BP plasma concentrations were determined by UPLC assay coupled with mass spectrometry and a PK/PD analysis was conducted to predict the efficacy of various dosing regimens by estimating values of the fT>MIC index for different minimum inhibitory concentrations (MIC). Tolerance at the site of IM injection was monitored by creatine kinase activity quantified with a validated chemistry system and clinical scorings.Results and discussionExcept one neurological reaction following one administration of penethamate hydriodide, the tolerance was good. Procaine BP alone, procaine BP/benzathine BP combination or penethamate hydriodide intramuscular administrations at a dosage of 22,000 IU BP/kg bwt q24h for 5 days would yield plasma concentrations that should be effective against bacteria with MIC of ≤0.256, 0.125 or 0.064 mg/L respectively. Of all the tested treatments, the use of a sodium BP by IV Constant Rate Infusion (CRI) for 10 hours a day was deemed to be the most efficient. All the formulations tested in this study are adequate to treat infections with susceptible Streptococcus equi

On directed interacting animals and directed percolation

We study the phase diagram of fully directed lattice animals with nearest-neighbour interactions on the square lattice. This model comprises several interesting ensembles (directed site and bond trees, bond animals, strongly embeddable animals) as special cases and its collapse transition is equivalent to a directed bond percolation threshold. Precise estimates for the animal size exponents in the different phases and for the critical fugacities of these special ensembles are obtained from a phenomenological renormalization group analysis of the correlation lengths for strips of width up to n=17. The crossover region in the vicinity of the collapse transition is analyzed in detail and the crossover exponent $\phi$ is determined directly from the singular part of the free energy. We show using scaling arguments and an exact relation due to Dhar that $\phi$ is equal to the Fisher exponent $\sigma$ governing the size distribution of large directed percolation clusters.Comment: 23 pages, 3 figures; J. Phys. A 35 (2002) 272

Leaf litter traits of invasive alien species slow down decomposition compared to Spanish natives: a broad phylogenetic comparison.

Leaf traits related to the performance of invasive alien species can influence nutrient cycling through litter decomposition. However, there is no consensus yet about whether there are consistent differences in functional leaf traits between invasive and native species that also manifest themselves through their "after life" effects on litter decomposition. When addressing this question it is important to avoid confounding effects of other plant traits related to early phylogenetic divergences and to understand the mechanism underlying the observed results to predict which invasive species will exert larger effects on nutrient cycling. We compared initial leaf litter traits, and their effect on decomposability as tested in standardized incubations, in 19 invasive-native pairs of co-familial species from Spain. They included 12 woody and seven herbaceous alien species representative of the Spanish invasive flora. The predictive power of leaf litter decomposition rates followed the order: growth form > family > status (invasive vs. native) > leaf type. Within species pairs litter decomposition tended to be slower and more dependent on N and P in invaders than in natives. This difference was likely driven by the higher lignin content of invader leaves. Although our study has the limitation of not representing the natural conditions from each invaded community, it suggests a potential slowing down of the nutrient cycle at ecosystem scale upon invasion. © Springer-Verlag 2009

A community effort in SARS-CoV-2 drug discovery.

peer reviewedThe COVID-19 pandemic continues to pose a substantial threat to human lives and is likely to do so for years to come. Despite the availability of vaccines, searching for efficient small-molecule drugs that are widely available, including in low- and middle-income countries, is an ongoing challenge. In this work, we report the results of an open science community effort, the "Billion molecules against Covid-19 challenge", to identify small-molecule inhibitors against SARS-CoV-2 or relevant human receptors. Participating teams used a wide variety of computational methods to screen a minimum of 1 billion virtual molecules against 6 protein targets. Overall, 31 teams participated, and they suggested a total of 639,024 molecules, which were subsequently ranked to find 'consensus compounds'. The organizing team coordinated with various contract research organizations (CROs) and collaborating institutions to synthesize and test 878 compounds for biological activity against proteases (Nsp5, Nsp3, TMPRSS2), nucleocapsid N, RdRP (only the Nsp12 domain), and (alpha) spike protein S. Overall, 27 compounds with weak inhibition/binding were experimentally identified by binding-, cleavage-, and/or viral suppression assays and are presented here. Open science approaches such as the one presented here contribute to the knowledge base of future drug discovery efforts in finding better SARS-CoV-2 treatments.R-AGR-3826 - COVID19-14715687-CovScreen (01/06/2020 - 31/01/2021) - GLAAB Enric