FAUNA BURUANA. COLEOPTERA, Fam. Lamellicornia Coprophaga

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Plasmodium falciparum proteome changes in response to doxycycline treatment

<p>Abstract</p> <p>Background</p> <p>The emergence of <it>Plasmodium falciparum </it>resistance to most anti-malarial compounds has highlighted the urgency to develop new drugs and to clarify the mechanisms of anti-malarial drugs currently used. Among them, doxycycline is used alone for malaria chemoprophylaxis or in combination with quinine or artemisinin derivatives for malaria treatment. The molecular mechanisms of doxycycline action in <it>P. falciparum </it>have not yet been clearly defined, particularly at the protein level.</p> <p>Methods</p> <p>A proteomic approach was used to analyse protein expression changes in the schizont stage of the malarial parasite <it>P. falciparum </it>following doxycycline treatment. A comparison of protein expression between treated and untreated protein samples was performed using two complementary proteomic approaches: two-dimensional fluorescence difference gel electrophoresis (2D-DIGE) and isobaric tagging reagents for relative and absolute quantification (iTRAQ).</p> <p>Results</p> <p>After doxycycline treatment, 32 and 40 <it>P. falciparum </it>proteins were found to have significantly deregulated expression levels by 2D-DIGE and iTRAQ methods, respectively. Although some of these proteins have been already described as being deregulated by other drug treatments, numerous changes in protein levels seem to be specific to doxycycline treatment, which could perturb apicoplast metabolism. Quantitative reverse transcription polymerase chain reaction (RT-PCR) was performed to confirm this hypothesis.</p> <p>Conclusions</p> <p>In this study, a specific response to doxycycline treatment was distinguished and seems to involve mitochondrion and apicoplast organelles. These data provide a starting point for the elucidation of drug targets and the discovery of mechanisms of resistance to anti-malarial compounds.</p

Phylogeny of the Oniticellini and Onthophagini Dung Beetles (Scarabaeidae, Scarabaeinae) from Morphological Evidence

A phylogenetic study was conducted to hypothesize relationships of most of the genera of the Oniticellini and Onthophagini for the first time using morphological characters from a diverse array of external and internal sclerites. The monophyly and sister relationship of both tribes was found using Bayesian and parsimony analyses with heavily to moderately weighted data. An alternative hypothesis based on parsimony analyses of unweighted or slightly weighted data show a paraphyletic Oniticellini without the Onthophagini, although recognition of the subtribe Helictopleurina as a tribe would eliminate non-monophyly. Of the three Oniticellini subtribes, the Helictopleurina and Drepanocerina are monophyletic. There is no support for the monophyly of the Oniticellina or the Onthophagini subtribe Alloscelina, as currently defined. The genus Liatongus is paraphyletic, while strong support was found for monophyly of the Madagascan genus, Helictopleurus. The genus Onthophagus is never monophyletic in any analysis performed. Two new subtribes are also proposed: Liatongina subtr. n. including the genus Liatongus and Attavicina subtr. n. including the genera Attavicinus and Paroniticellus. Topological evidence shows that the ancestral oniticellines and onthophagines were all coprophagous with alternative food sources evolving relatively recently. Both myrmecophily and termitophily probably evolved only once in the onthophagines. The phylogenetic analysis supports an African origin for the two tribes, with a relatively early age for the split of the Madagascar helictopleurines from the remaining oniticellines via dispersal. Furthermore, the presence of the oniticellines in the New World is hypothesized to be due to two relatively old dispersal events via Beringia and two relatively recent trans-Atlantic invasions of the Caribbean

Ataenius Corporaali, nov. sp. de Sumatra

Volume: 67Start Page: 117End Page: 11

Descriptions sommaires de quelques Bolbocerini [Col.]

Boucomont Antoine. Descriptions sommaires de quelques Bolbocerini [Col.]. In: Bulletin de la Société entomologique de France, volume 7 (9),1902. pp. 184-185

Notes sur quelques sous-genres de Bolboceras [Col.] et description d’un sous-genre nouveau

Boucomont Antoine. Notes sur quelques sous-genres de Bolboceras [Col.] et description d’un sous-genre nouveau. In: Bulletin de la Société entomologique de France, volume 14 (7),1909. pp. 116-118

Genre nouveau et espèces nouvelles de Coprophages [Col.], du Yunnan

Boucomont Antoine. Genre nouveau et espèces nouvelles de Coprophages [Col.], du Yunnan. In: Bulletin de la Société entomologique de France, volume 17 (13),1912. pp. 275-278

Coprophaga Africana. Genre nouveau et especes nouvelles

Volume: 8Start Page: 261End Page: 26

Genre nouveau et espèces nouvelles de Coprophages [Col.], du Yunnan

Boucomont Antoine. Genre nouveau et espèces nouvelles de Coprophages [Col.], du Yunnan. In: Bulletin de la Société entomologique de France, volume 17 (13),1912. pp. 275-278