Stephen Kings Das Mädchen (Schneekluth Verlag) – Eine rhetorische Lektüre des Schutzumschlags

“The book as an object is comfortingly substantial in its content and its material presence. At a time when so much information is dispersed in virtual form, it is especially important to examine the book as a distinctive object reflecting a marriage of authors’ words and designers’ vision.” In Bibliotheken und Archiven findet man ihn selten – zumindest nicht am Stück. Wenn doch, dann an Sonderstandorten, in Kartons und auch nur dann, wenn genug Platz zu deren Aufbewahrung vorhanden ist. Selt..

Taste, A New Incentive to Switch to (R)-Praziquantel in Schistosomiasis Treatment

Schistosomiasis, or Bilharzia, is a parasitic disease caused by flatworms, which affects about 200 million people worldwide. Praziquantel (PZQ) is the drug compound of choice in the control and treatment of this disease. Only half of the drug dose currently administered actually has activity against schistosomiasis, whereas the other half has no activity. Therefore, the WHO has assigned the low-cost preparation of the pure active component a key priority for future PZQ research and development. PZQ has two major administration drawbacks, the first being the high dose needed, the second its well documented bitter taste. Attempts of masking the unpleasant taste have not been successful. We hypothesized that the non-active component in PZQ would be the main contributor to the unpleasant taste of the drug. We determined the extent of bitterness for regular PZQ compared to the pure active component in a taste study in humans. We found that the pure active component alone is significantly less bitter than regular PZQ. This new finding should serve as an additional incentive for the PZQ research and development community to provide a low-cost, large-scale preparation route to the pure active component of PZQ

A Sound Approach to Language Matters: In Honor of Ocke-Schwen Bohn

The contributions in this Festschrift were written by Ocke’s current and former PhD-students, colleagues and research collaborators. The Festschrift is divided into six sections, moving from the smallest building blocks of language, through gradually expanding objects of linguistic inquiry to the highest levels of description - all of which have formed a part of Ocke’s career, in connection with his teaching and/or his academic productions: “Segments”, “Perception of Accent”, “Between Sounds and Graphemes”, “Prosody”, “Morphology and Syntax” and “Second Language Acquisition”. Each one of these illustrates a sound approach to language matters

Auflösung des Sehens. Bilder, Vergrößerungen, Blicke

Lutz H. Auflösung des Sehens. Bilder, Vergrößerungen, Blicke. In: Bothe T, Suter R, eds. Prekäre Bilder. Eikones. Paderborn: Wilhelm Fink; 2010: 197-223

Trinuclear Nickel Complexes with Triplesalen Ligands: Simultaneous Occurrence of Mixed Valence and Valence Tautomerism in the Oxidized Species

Glaser T, Heidemeier M, Fröhlich R, Hildebrandt P, Bothe E, Bill E. Trinuclear Nickel Complexes with Triplesalen Ligands: Simultaneous Occurrence of Mixed Valence and Valence Tautomerism in the Oxidized Species. Inorg. Chem. 2005;44(15):5467-5482.The coordination chemistries of the triple tetradentate triplesalen ligands H(6)talen, H(6)talen(t-Bu2), and H(6)talen(NO2) have been investigated with nickel(II). These triplesalen ligands provide three salen-like coordination environments bridged in a meta-phenylene arrangement by a phloroglucinol backbone. The structures of the complexes [(talen)Ni-3(II)], [(talen(t-Bu2))Ni-3(II)], and [(talen(NO2))Ni-3(II)] have been determined by single-crystal X-ray diffraction, All three compounds are composed of neutral trinuclear complexes with square-planar coordinated Ni-II ions in a salen-like coordination environment. Whereas the overall molecular structure of [(talen(NO2))Ni-II3] is nearly planar, the structures of [(talen)Ni-II3] and [(talen(t-Bu2))Ni-3(II)] are bowl-shaped as a result of ligand folding. The strongest ligand folding occurs at the central nickel-phenolate bond of [(talen(t-Bu2))Ni-3(II)], resulting in the formation of a chiral hemispherical pocket, The dependence of the physical properties by the substituents on the terminal phenolates has been studied by FTIR, resonance Raman, UV-vis-NIR absorption, and electrochemistry. The three nickel-salen subunits are electronically interacting via the 7, system of the bridging phloroglucinol backbone. The strength of this interaction is mediated by two opposing effects: the electron density at the terminal phenolates and the folding of the ligand at the central phenolates. The parent complex [(talen)Ni-3(II)] is irreversibly oxidized at 0.32 V versus ferrocenium/ferrocene (Fc(+)/ Fc), whereas [(talen(t-Bu2))Ni-3(II)] and [(talen(NO2))Ni-3(II)] exhibit reversible oxidations at 0.22 V versus Fc(+)/Fc and 0.52 V versus Fc(+)/Fc, respectively. The oxidized species [(talen(t-Bu2))Ni-3](+) and [(talen(NO2))Ni-3](+) undergo a valence-tautomeric transformation involving a Ni-II and a phenoxyl radical species, as observed by EPR spectroscopy. Thus, these oxidized forms exhibit the phenomena of valence tautomerism and mixed valence simultaneously. The extent of delocalization of the radical species and of the Ni-II species is discussed

Bildung und Hochschule. Impulse für Studium und Lehre am Beispiel des Leuphana College

Beck K, Bothe T, Glaser T, Heuer C, Schütz J, Seifert A, eds. Bildung und Hochschule. Impulse für Studium und Lehre am Beispiel des Leuphana College. Münster: Waxmann; 2016

Bildung und Hochschule. Impulse für Studium und Lehre am Beispiel des Leuphana College

Beck K, Bothe T, Glaser T, Heuer C, Schütz J, Seifert A, eds. Bildung und Hochschule. Impulse für Studium und Lehre am Beispiel des Leuphana College. Münster: Waxmann; 2016

Integrative Verknüpfung von Studium und Praxis am Leuphana College

Hellmann K, Teigeler M, Seifert A. Integrative Verknüpfung von Studium und Praxis am Leuphana College. In: Beck K, Bothe T, Glaser T, Heuer C, Schütz J, Seifert A, eds. Bildung und Hochschule. Impulse für Studium und Lehre am Beispiel des Leuphana College. Münster: Waxmann; 2016: 205-216

Highly oxidized diiron complexes: generation, spectroscopy, and stabilities

Strautmann JBH, von Richthofen C-GF, George SDB, Bothe E, Bill E, Glaser T. Highly oxidized diiron complexes: generation, spectroscopy, and stabilities. CHEMICAL COMMUNICATIONS. 2009;(19):2637-2639.Oxidation of the diferric complex [(LFeOFeL)-O-III-L-III] to the monoradical complex [(LFeOFeL center dot)-O-III-L-III](+) and the diradical complex [(LFeOFeL center dot)-Fe-center dot-O-III-L-III](2+) is followed by a decay into monomeric complexes including a highly reactive putative [LFeIV=O] complex