1,278 research outputs found
Effect of high frequency ultrasounds on lycopene and total phenolic concentration, antioxidant properties and α-glucosidase inhibitory activity of tomato juice
Tomato juice was subjected to high frequency ultrasounds(378 and 583 kHz)at increasing energy densities (up to 250 MJ/m3). Results relevant to the treatments at high frequency providing an energy density of 250 MJ/m3 were compared with those obtained at 24 kHz delivering the same energy density. Lycopene and total phenolic concentration, as well as the α-glucosidase inhibitory activityof tomato juice, were not affected by ultrasound regardless the frequency and energy density. However, the antioxidant properties were negatively affected by high frequency ultrasounds
Mortality rates and division of labor in the leaf-cutting ant, Atta colombica
Division of labor in social groups is affected by the relative costs and benefits of conducting different tasks. However, most studies have examined the dynamics of division of labor, rather than the costs and benefits that presumably underlie the evolution of such systems. In social insects, division of labor may be simplistically described as a source-sink system, with external tasks, such as foraging, acting as sinks for the work force. The implications of two distinct sinks – foraging and waste-heap working – for division of labor were examined in the leaf-cutting ant Atta colombica. Intrinsic mortality rates were similar across external task groups. Exposure to waste (a task-related environment) led to a 60% increase in the mortality rate of waste-heap workers compared to workers not exposed to waste. Given the small number of workers present in the waste-heap task group, such increases in mortality are unlikely to affect division of labor and task allocation dramatically, except perhaps under conditions of stress
Dust emission at 8-mic and 24-mic as Diagnostics of HII Region Radiative Transfer
We use the Spitzer SAGE survey of the Magellanic Clouds to evaluate the
relationship between the 8-mic PAH emission, 24-mic hot dust emission, and HII
region radiative transfer. We confirm that in the higher-metallicity Large
Magellanic Cloud, PAH destruction is sensitive to optically thin conditions in
the nebular Lyman continuum: objects identified as optically thin candidates
based on nebular ionization structure show 6 times lower median 8-mic surface
brightness (0.18 mJy arcsec^-2) than their optically thick counterparts (1.2
mJy arcsec^-2). The 24-mic surface brightness also shows a factor of 3 offset
between the two classes of objects (0.13 vs 0.44 mJy arcsec^-2, respectively),
which is driven by the association between the very small dust grains and
higher density gas found at higher nebular optical depths. In contrast, PAH and
dust formation in the low-metallicity Small Magellanic Cloud is strongly
inhibited such that we find no variation in either 8-mic or 24-mic emission
between our optically thick and thin samples. This is attributable to extremely
low PAH and dust production together with high, corrosive UV photon fluxes in
this low-metallicity environment. The dust mass surface densities and
gas-to-dust ratios determined from dust maps using Herschel HERITAGE survey
data support this interpretation.Comment: Accepted to ApJ, May 15, 2017. 10 pages, 9 figure
Hierarchical progressive surveys. Multi-resolution HEALPix data structures for astronomical images, catalogues, and 3-dimensional data cubes
Scientific exploitation of the ever increasing volumes of astronomical data
requires efficient and practical methods for data access, visualisation, and
analysis. Hierarchical sky tessellation techniques enable a multi-resolution
approach to organising data on angular scales from the full sky down to the
individual image pixels. Aims. We aim to show that the Hierarchical progressive
survey (HiPS) scheme for describing astronomical images, source catalogues, and
three-dimensional data cubes is a practical solution to managing large volumes
of heterogeneous data and that it enables a new level of scientific
interoperability across large collections of data of these different data
types. Methods. HiPS uses the HEALPix tessellation of the sphere to define a
hierarchical tile and pixel structure to describe and organise astronomical
data. HiPS is designed to conserve the scientific properties of the data
alongside both visualisation considerations and emphasis on the ease of
implementation. We describe the development of HiPS to manage a large number of
diverse image surveys, as well as the extension of hierarchical image systems
to cube and catalogue data. We demonstrate the interoperability of HiPS and
Multi-Order Coverage (MOC) maps and highlight the HiPS mechanism to provide
links to the original data. Results. Hierarchical progressive surveys have been
generated by various data centres and groups for ~200 data collections
including many wide area sky surveys, and archives of pointed observations.
These can be accessed and visualised in Aladin, Aladin Lite, and other
applications. HiPS provides a basis for further innovations in the use of
hierarchical data structures to facilitate the description and statistical
analysis of large astronomical data sets.Comment: 21 pages, 6 figures. Accepted for publication in Astronomy &
Astrophysic
Colloidal, tribological and sensory properties of oral nutritional supplements
This study aims to evaluate the physicochemical and sensory properties of oral nutritional supplements (ONSs). High physical stability was measured in ONSs with mean particle sizes <0.33 !m and viscosity >19.3 mPa·s. ONSs formulated with dairy-soy protein mixtures displayed low friction coefficients, whereas ONSs containing dairy proteins alone had high friction coefficient values in the boundary regime. Sensory analysis revealed low to medium liking across the products and the highest preference was found in samples with the highest perceived 'sweetness', 'vanilla aroma' and 'thickness'. The results will underpin the formulation of novel ONSs with good physical stability and sensory acceptability
Evaluating 5-nitrofurans as trypanocidal agents
The nitroheterocycle nifurtimox, as part of a nifurtimox-eflornithine combination therapy, represents one of a limited number of treatments targeting Trypanosoma brucei, the causative agent of human African trypanosomiasis. The mode of action of this prodrug involves an initial activation reaction catalysed by a type I nitroreductase (NTR), an enzyme found predominantly in prokaryotes, leading to the formation of a cytotoxic unsaturated open chain nitrile metabolite. Here, we evaluate the trypanocidal activity of a library of other 5-nitrofurans against bloodstream form T. brucei as a preliminary step in the identification of additional nitroaromatic compounds that could potentially partner eflornithine. Biochemical screening against purified enzyme revealed that all 5-nitrofurans were effective substrates for TbNTR with the preferred compounds having apparent kcat/KM values approximately 50-fold greater than nifurtimox. For several compounds, in vitro reduction by this nitroreductase yielded products characterized by mass spectroscopy as either unsaturated or saturated open chain nitriles. When tested against bloodstream form T. brucei, many of the derivatives displayed significant growth inhibitory properties with the most potent compounds generating IC50 values around 200 nM. The anti-parasitic activity of the most potent agents was demonstrated to be NTR dependent as parasites having reduced levels of the enzyme displayed resistance to the compounds while parasites over expressing TbNTR showed hypersensitivity. We conclude that other members of the 5-nitrofurans class of nitroheterocycles have potential to treat human African trypanosomiasis perhaps as an alternative partner prodrug to nifurtimox in the next generation of eflornithine-based combinational therapies
The remnant of SN1987A revealed at (sub-)mm wavelengths
Context: Supernova 1987A (SN1987A) exploded in the Large Magellanic Cloud
(LMC). Its proximity and rapid evolution makes it a unique case study of the
early phases in the development of a supernova remnant. One particular aspect
of interest is the possible formation of dust in SN1987A, as SNe could
contribute significantly to the dust seen at high redshifts. Aims: We explore
the properties of SN1987A and its circumburst medium as seen at mm and sub-mm
wavelengths, bridging the gap between extant radio and infrared (IR)
observations of respectively the synchrotron and dust emission. Methods:
SN1987A was observed with the Australia Telescope Compact Array (ATCA) at 3.2
mm in July 2005, and with the Atacama Pathfinder EXperiment (APEX) at 0.87 mm
in May 2007. We present the images and brightness measurements of SN1987A at
these wavelengths for the first time. Results: SN1987A is detected as an
unresolved point source of 11.2 +/- 2.0 mJy at 3.2 mm (5" beam) and 21 +/- 4
mJy at 0.87 mm (18" beam). These flux densities are in perfect agreement with
extrapolations of the powerlaw radio spectrum and modified-blackbody dust
emission, respectively. This places limits on the presence of free-free
emission, which is similar to the expected free-free emission from the ionized
ejecta from SN1987A. Adjacent, fainter emission is observed at 0.87 mm
extending ~0.5' towards the south-west. This could be the impact of the
supernova progenitor's wind when it was still a red supergiant upon a dense
medium. Conclusions: We have established a continuous spectral energy
distribution for the emission from SN1987A and its immediate surroundings,
linking the IR and radio data. This places limits on the contribution from
ionized plasma. Our sub-mm image reveals complexity in the distribution of cold
dust surrounding SN1987A, but leaves room for freshly synthesized dust in the
SN ejecta.Comment: Accepted for publication in Astronomy and Astrophysics Letters on 28
April 2011. A better quality figure 1 can be had from
http://www.astro.keele.ac.uk/~jacco/research/SN1987A087mm.ep
Leukocyte Bim deficiency does not impact atherogenesis in ldlr -/- mice, despite a pronounced induction of autoimmune inflammation
Proapoptotic Bcl-2 family member Bim is particularly relevant for deletion of autoreactive and activated T and B cells, implicating Bim in autoimmunity. As atherosclerosis is a chronic inflammatory process with features of autoimmune disease, we investigated the impact of hematopoietic Bim deficiency on plaque formation and parameters of plaque stability. Bim−/− or wild type bone marrow transplanted ldlr−/− mice were fed a Western type diet (WTD) for 5 or 10 weeks, after which they were immunophenotyped and atherosclerotic lesions were analyzed. Bim−/− transplanted mice displayed splenomegaly and overt lymphocytosis. CD4+ and CD8+ T cells were more activated (increased CD69 and CD71 expression, increased interferon gamma production). B cells were elevated by 147%, with a shift towards the pro-atherogenic IgG-producing B2 cell phenotype, resulting in a doubling of anti-oxLDL IgG1 antibody titers in serum of bim−/− mice. Bim−/− mice displayed massive intraplaque accumulation of Ig complexes and of lesional T cells, although this did not translate in changes in plaque size or stability features (apoptotic cell and macrophage content). The surprising lack in plaque phenotype despite the profound pro-atherogenic immune effects may be attributable to the sharp reduction of serum cholesterol levels in WTD fed bim−/− mice
Insoluble glycogen, a metabolizable internal adsorbent, decreases the lethality of endotoxin shock in rats
Insoluble glycogen is an enzymatically modified form of naturally occurring soluble glycogen with a great adsorbing capacity. It can be metabolized by phagocytes to glucose. In this study we used insoluble glycogen intravenously in the experimental endotoxin shock of rats. Wistar male rats were sensitized to endotoxin by Pb acetate. The survival of rats were compared in groups of animals endotoxin shock treated and non-treated with insoluble glycogen. Furthermore, we have determined in vitro the binding capacity of insoluble glycogen for endotoxin, tumour necrosis factor alpha, interleukin-1 and secretable phospholipase A2. Use of 10 mg/kg dose of insoluble glycogen could completely prevent the lethality of shock induced by LD50 quantity of endotoxin in rats. All animals treated survived. Insoluble glycogen is a form of ‘metabolizable internal adsorbents’. It can potentially be
used for treatment of septic shock
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