Improvement and evaluation of the mesoscale meteorological model MM5 for air-quality applications in Southern California and the San Joaquin Valley: Final Report

The objective of the Penn State University (PSU) part of the study was to investigate the MM5's ability to simulate wintertime fog in the San Joaquin Valley (SJV) and summertime sea breeze flows in the South Coast Air Basin (SoCAB). For the SJV work the MM5 was configured with four nested grid and an advanced turbulence sub-model. Applied to the event of 7-12 December 1995, observed during the IMS-95 program, the model's innermost domain used 40 vertical layers and a 4-km mesh. Several experiments were performed to improve the turbulence sub-model for saturated conditions and to provide more accurate initial conditions for soil temperature and moisture. Results showed the MM5 correctly predicted the type of visibility obscuration (fog, haze, status or clear) in 14 out of the 18 events. For depth was estimated by the MM5 with a mean absolute error of only 92 m and a mean error of -41 m. Mean errors for both the surface temperature and dew point were within +1C, while the mean absolute errors were ~1.5-2.0 C. As a consequence, the mean error for dew-point depression is very small. Thus, the MM5 was shown to simulate fog and haze in the SJV with considerable accuracy. Extensions of the turbulence sub-model to include saturation effects and the specification of accurate soil temperature and moisture were important for simulating fog characteristics in the case. Additionally, MM5 was able to simulate the light and variable winds in the Sacramento and San Joaquin Valleys that prevailed during this event. Moreover, the winds responded quite well to the slowly changing synoptic-scale weather, as well, as confirmed by the observations. the objective for the San Jose State University (SJSU) work included use of SCOS97 data and MM5 simulations to understand meteorological factors in the formation of high ozone concentrations during 4-7 August 1997. Meteorological data for the case study included observations at 110 SCOS97 surface sites and upper air measurements from 12 rawinsonde and 26 RWP/RASS profilers. the MM5 version contained the PSU Marine Boundary Layer Initialization (MBLI) scheme, quadruple nested grids (horizontal resolutions of 135, 45, 15, and 5 km), 30 vertical layers, minimum sigma level of 46 m, USGS global land-use, GDAS global gridded model analyses and SSTs, analysis nudging, observational nudging, force-restore surface temperature, 1.5 order TKE, one-way continuous nesting, and a MAPS statistical evaluation. Analysis showed the ozone episode resulting from a unique combination of large-scale upper level synoptic forcings that included a weak local coastal 700 mb anticyclone. Its movement around SoCAB rotated the upper level synoptic background flow from its normal westerly onshore direction to a less common offshore easterly flow during the nighttime period preceding the episode. The resulting easterly upper level synoptic background winds influenced surface flow direction at inland sites, so that a surface frontal convergence zone resulted where the easterly flow met the westerly onshore sea breeze flow. The maximum inland penetration of the convergence zone was about to the San Gabriel Mountain peaks, the location of daytime maximum ozone-episode concentrations. The current MM5 simulations reproduced the main qualitative features of the evolution of the diurnal sea breeze cycle in the SoCAB with reasonable accuracy. The position of the sea breeze front during its daytime inland penetration and nighttime retreat could be determined from the simulated wind fields. the accuracy of predicted MM5 surface winds and temperatures over SoCAB were improved by the modifications of its deep-soil temperatures, interpolation of predicted temperatures and winds to SCOS97 observational levels, use of updated urban land-use patterns, and use of corrected input values for ocean and urban surface roughness parameter values.Prepared for the California Air Resources Board and California Environmental Protection AgencySJSU Foundation Subcontract no. 22-1505-7384Approved for public release; distribution is unlimited

Reflections on the Scientific Legacy of Sergej S. Zilitinkevich on PBL and Urban Parameterizations in NWP Models

The paper summarizes many of the scientific achievements of Professor Sergej S. Zilitinkevich (1936–2021). It first focuses on his basic and applied atmospheric boundary layer research contributions. It then reviews their applications within research and operational numerical weather prediction and air quality modeling, showing their contribution to solving modeling problems related to extremely-stable and -unstable boundary layers

An observational case study of synergies between an intense heat wave and the urban heat island in Beijing

The focus of this study is an intense heat episode that occurred on 9–13 July 2017 in Beijing, China, that resulted in severe impacts on natural and human variables, including record-setting daily electricity consumption levels. This event was observed and analyzed with a suite of local and mesoscale instruments, including a high-density automated weather station network, soil moisture sensors, and ground-based vertical instruments (e.g., a wind profiler, a ceilometer, and three radiometers) situated in and around the city, as well as electric power consumption data and analysis data from the U.S. National Centers for Environmental Prediction. The results show that the heat wave originated from dry adiabatic warming induced by the dy-namic downslope and synoptic subsidence. The conditions were aggravated by the increased air humidity during subsequent days, which resulted in historically high records of the heat index (i.e., an index repre-senting the apparent temperature that incorporates both air temperature and moisture). The increased thermal energy and decreased boundary layer height resulted in a highly energized urban boundary layer. The differences between urban and rural thermal conditions throughout almost the entire boundary layer were enhanced during the heat wave, and the canopy-layer urban heat island intensity (UHII) reached up to 8°C at a central urban station at 2300 local standard time 10 July. A double-peak pattern in the diurnal cycle of UHIIs occurred during the heat wave and differed from the single-peak pattern of the decadal average UHII cycles. Different spatial distributions of UHII values occurred during the day and night

Rivaroxaban for secondary stroke prevention in patients with embolic strokes of undetermined source : Design of the NAVIGATE ESUS randomized trial

Peer reviewe

Urban climate and resiliency: A synthesis report of state of the art and future research directions

The Urban Climate and Resiliency-Science Working Group (i.e., The WG) was convened in the summer of 2018 to explore the scientific grand challenges related to climate resiliency of cities. The WG leveraged the presentations at the 10th International Conference on Urban Climate (ICUC10) held in New York City (NYC) on 6–10 August 2018 as input forum. ICUC10 was a collaboration between the International Association of Urban Climate, American Meteorological Society, and World Meteorological Organization. It attracted more than 600 participants from more than 50 countries, resulting in close to 700 oral and poster presentations under the common theme of “Sustainable & Resilient Urban Environments”. ICUC10 covered topics related to urban climate and weather processes with far-reaching implications to weather forecasting, climate change adaptation, air quality, health, energy, urban planning, and governance. This article provides a synthesis of the analysis of the current state of the art and of the recommendations of the WG for future research along each of the four Grand Challenges in the context of urban climate and weather resiliency; Modeling, Observations, Cyber-Informatics, and Knowledge Transfer & Applications

Project ATLANTA (ATlanta Land-use ANalysis: Temperature and Air quality): A Study of how the Urban Landscape Affects Meteorology and Air Quality Through Time

It is our intent through this investigation to help facilitate measures that can be Project ATLANTA (ATlanta Land-use ANalysis: applied to mitigate climatological or air quality Temperature and Air-quality) is a NASA Earth degradation, or to design alternate measures to sustain Observing System (EOS) Interdisciplinary Science or improve the overall urban environment in the future. investigation that seeks to observe, measure, model, and analyze how the rapid growth of the Atlanta. The primary objectives for this research effort are: 1) To In the last half of the 20th century, Atlanta, investigate and model the relationship between Atlanta Georgia has risen as the premier commercial, urban growth, land cover change, and the development industrial, and transportation urban area of the of the urban heat island phenomenon through time at southeastern United States. The rapid growth of the nested spatial scales from local to regional; 2) To Atlanta area, particularly within the last 25 years, has investigate and model the relationship between Atlanta made Atlanta one of the fastest growing metropolitan urban growth and land cover change on air quality areas in the United States. The population of the through time at nested spatial scales from local to Atlanta metropolitan area increased 27% between 1970 regional; and 3) To model the overall effects of urban and 1980, and 33% between 1980-1990 (Research development on surface energy budget characteristics Atlanta, Inc., 1993). Concomitant with this high rate of across the Atlanta urban landscape through time at population growth, has been an explosive growth in nested spatial scales from local to regional. Our key retail, industrial, commercial, and transportation goal is to derive a better scientific understanding of how services within the Atlanta region. This has resulted in land cover changes associated with urbanization in the tremendous land cover change dynamics within the Atlanta area, principally in transforming forest lands to metropolitan region, wherein urbanization has urban land covers through time, has, and will, effect consumed vast acreas of land adjacent to the city local and regional climate, surface energy flux, and air proper and has pushed the rural/urban fringe farther quality characteristics. Allied with this goal is the and farther away from the original Atlanta urban core. prospect that the results from this research can be An enormous transition of land from forest and applied by urban planners, environmental managers agriculture to urban land uses has occurred in the and other decision-makers, for determining how Atlanta area in the last 25 years, along with subsequent urbanization has impacted the climate and overal

Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study

The prevalence of hypertension in African Americans (AAs) is higher than in other US groups; yet, few have performed genome-wide association studies (GWASs) in AA. Among people of European descent, GWASs have identified genetic variants at 13 loci that are associated with blood pressure. It is unknown if these variants confer susceptibility in people of African ancestry. Here, we examined genome-wide and candidate gene associations with systolic blood pressure (SBP) and diastolic blood pressure (DBP) using the Candidate Gene Association Resource (CARe) consortium consisting of 8591 AAs. Genotypes included genome-wide single-nucleotide polymorphism (SNP) data utilizing the Affymetrix 6.0 array with imputation to 2.5 million HapMap SNPs and candidate gene SNP data utilizing a 50K cardiovascular gene-centric array (ITMAT-Broad-CARe [IBC] array). For Affymetrix data, the strongest signal for DBP was rs10474346 (P= 3.6 × 10−8) located near GPR98 and ARRDC3. For SBP, the strongest signal was rs2258119 in C21orf91 (P= 4.7 × 10−8). The top IBC association for SBP was rs2012318 (P= 6.4 × 10−6) near SLC25A42 and for DBP was rs2523586 (P= 1.3 × 10−6) near HLA-B. None of the top variants replicated in additional AA (n = 11 882) or European-American (n = 69 899) cohorts. We replicated previously reported European-American blood pressure SNPs in our AA samples (SH2B3, P= 0.009; TBX3-TBX5, P= 0.03; and CSK-ULK3, P= 0.0004). These genetic loci represent the best evidence of genetic influences on SBP and DBP in AAs to date. More broadly, this work supports that notion that blood pressure among AAs is a trait with genetic underpinnings but also with significant complexit

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.

Blood pressure is a heritable trait influenced by several biological pathways and responsive to environmental stimuli. Over one billion people worldwide have hypertension (≥140 mm Hg systolic blood pressure or  ≥90 mm Hg diastolic blood pressure). Even small increments in blood pressure are associated with an increased risk of cardiovascular events. This genome-wide association study of systolic and diastolic blood pressure, which used a multi-stage design in 200,000 individuals of European descent, identified sixteen novel loci: six of these loci contain genes previously known or suspected to regulate blood pressure (GUCY1A3-GUCY1B3, NPR3-C5orf23, ADM, FURIN-FES, GOSR2, GNAS-EDN3); the other ten provide new clues to blood pressure physiology. A genetic risk score based on 29 genome-wide significant variants was associated with hypertension, left ventricular wall thickness, stroke and coronary artery disease, but not kidney disease or kidney function. We also observed associations with blood pressure in East Asian, South Asian and African ancestry individuals. Our findings provide new insights into the genetics and biology of blood pressure, and suggest potential novel therapeutic pathways for cardiovascular disease prevention

URBAN TERRAIN CLIMATOLOGY AND REMOTE SENSING *

. Urban areas have been conceived of as monolithic heat islands because traditional ground observation techniques do not lend themselves to more specific analyses. Observations of urban energy-exchange obtained from calibrated electro-optical scanners combined with energy budget simulation techniques provide tools to relate the urban land use mosaic to the heat island phenomenon. Maps of surface energy-related phenomena were made from airborne scanner outputs for selected flightpaths across the city of Baltimore, Maryland. Conditions for the flight time were simulated according to the various types of land use using an energy budget simulation model which lends itself to extrapolation of simulated grid-point conditions into a map form. Maps made by simulation compare sufficiently well with those made by aerial observation to encourage further refinement of the simulation approach.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/72392/1/j.1467-8306.1976.tb01110.x.pd

Efficacy of finerenone in patients with type 2 diabetes, chronic kidney disease and altered markers of liver steatosis and fibrosis: A FIDELITY subgroup analysis

AIM Investigating the effect of finerenone on liver function, cardiovascular and kidney composite outcomes in patients with chronic kidney disease and type 2 diabetes, stratified by their risk of liver steatosis, inflammation and fibrosis. MATERIALS AND METHODS Post hoc analysis stratified patients (N = 13 026) by liver fibrosis and enzymes: high risk of steatosis (hepatic steatosis index >36); elevated transaminases [alanine transaminase (ALT) >33 (males) and >25 IU/L (females)]; and fibrosis-4 (FIB-4) index scores >3.25, >2.67 and >1.30. Liver enzymes were assessed by changes in ALT, aspartate aminotransferase and gamma-glutamyl transferase. Composite kidney outcome was defined as onset of kidney failure, sustained estimated glomerular filtration rate decline ≥57% from baseline over ≥4 weeks or kidney death. Composite cardiovascular outcome was defined as cardiovascular death, non-fatal myocardial infarction, non-fatal stroke or hospitalization for heart failure. RESULTS ALT, aspartate aminotransferase and gamma-glutamyl transferase levels were consistent between treatment groups and remained stable throughout. Finerenone consistently reduced the risk of composite kidney outcome, irrespective of altered liver tests. Higher FIB-4 score was associated with higher incidence rates of composite cardiovascular outcome. Finerenone reduced the risk of composite cardiovascular outcome versus placebo in FIB-4 subgroups by 52% (>3.25), 39% (>2.67) and 24% (>1.30) (p values for interaction = .01, .13 and .03, respectively). CONCLUSIONS Finerenone has neutral effects on liver parameters in patients with chronic kidney disease and type 2 diabetes. Finerenone showed robust and consistent kidney benefits in patients with altered liver tests, and profound cardiovascular benefits even in patients with higher FIB-4 scores who were at high risk of developing cardiovascular complications