Compact Dual-Band and Wideband Filters With Resonant Apertures in Rectangular Waveguide

[EN] The objective of this article is to describe a new family of microwave bandpass filters in the rectangular waveguide based on resonant apertures, which can be used to implement both single- and dual-band transfer functions. The use of capacitive stubs and a staircase configuration is also discussed in order to enhance the out-of-band response and the selectivity of the filter with respect to the state of the art. Finally, simulations are compared with measured results, showing very good agreement, thereby fully validating both the new filter topologies and the design procedure.This work was supported in part by the Ministerio de Ciencia e Innovacion, Spanish Government, through the Research and Development Project PID2019-103982RB, under Grant MCIN/AEI/10.13039/501100011033; and in part by the Generalitat Valenciana under Santiago Grisolia Grant GRISOLIA/2017/073. This article is an expanded version from the IEEE MTT-S International Microwave Symposium (IMS 2021), Atlanta, GA, USA, June 20-25, 2021 [DOI: 10.1109/IMS19712.2021.9574801].Valencia Sullca, JF.; Cogollos, S.; Boria Esbert, VE.; Guglielmi, M. (2022). Compact Dual-Band and Wideband Filters With Resonant Apertures in Rectangular Waveguide. IEEE Transactions on Microwave Theory and Techniques. 70(6):3125-3140. https://doi.org/10.1109/TMTT.2022.31623073125314070

NGS TREX: next generation sequences transcriptome profile explorer

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NGS-Trex : next generation sequencing transcriptome profile explorer

Background: Next-Generation Sequencing (NGS) technology has exceptionally increased the ability to sequence DNA in a massively parallel and cost-effective manner. Nevertheless, NGS data analysis requires bioinformatics skills and computational resources well beyond the possibilities of many "wet biology" laboratories. Moreover, most of projects only require few sequencing cycles and standard tools or workflows to carry out suitable analyses for the identification and annotation of genes, transcripts and splice variants found in the biological samples under investigation. These projects can take benefits from the availability of easy to use systems to automatically analyse sequences and to mine data without the preventive need of strong bioinformatics background and hardware infrastructure.Results: To address this issue we developed an automatic system targeted to the analysis of NGS data obtained from large-scale transcriptome studies. This system, we named NGS-Trex (NGS Transcriptome profile explorer) is available through a simple web interface http://www.ngs-trex.org and allows the user to upload raw sequences and easily obtain an accurate characterization of the transcriptome profile after the setting of few parameters required to tune the analysis procedure. The system is also able to assess differential expression at both gene and transcript level (i.e. splicing isoforms) by comparing the expression profile of different samples.By using simple query forms the user can obtain list of genes, transcripts, splice sites ranked and filtered according to several criteria. Data can be viewed as tables, text files or through a simple genome browser which helps the visual inspection of the data.Conclusions: NGS-Trex is a simple tool for RNA-Seq data analysis mainly targeted to "wet biology" researchers with limited bioinformatics skills. It offers simple data mining tools to explore transcriptome profiles of samples investigated taking advantage of NGS technologies. \ua9 2013 Mignone et al.; licensee BioMed Central Ltd

Multipactor radiation analysis within a waveguide region based on a frequency-domain representation of the dynamics of charged particles

[EN] A technique for the accurate computation of the electromagnetic fields radiated by a charged particle moving within a parallel-plate waveguide is presented. Based on a transformation of the time-varying current density of the particle into a time-harmonic current density, this technique allows the evaluation of the radiated electromagnetic fields both in the frequency and time domains, as well as in the near- and far-field regions. For this purpose, several accelerated versions of the parallel-plate Green's function in the frequency domain have been considered. The theory has been successfully applied to the multipactor discharge occurring within a two metal-plates region. The proposed formulation has been tested with a particle-in-cell code based on the finite-difference time-domain method, obtaining good agreement.The authors would like to thank ESA/ESTEC for having funded this research activity through the Contract "RF Breakdown in Multicarrier Systems" (Contract No. 19918/06/NL/GLC).Gimeno, B.; Sorolla, E.; Anza, S.; Vicente, C.; Gil, J.; Pérez, AM.; Boria Esbert, VE.... (2009). Multipactor radiation analysis within a waveguide region based on a frequency-domain representation of the dynamics of charged particles. Physical review. E, Statistical, nonlinear, and soft matter physics. 79(4):1-9. https://doi.org/10.1103/PhysRevE.79.046604S19794Figueroa, H., Gai, W., Konecny, R., Norem, J., Ruggiero, A., Schoessow, P., & Simpson, J. (1988). Direct Measurement of Beam-Induced Fields in Accelerating Structures. Physical Review Letters, 60(21), 2144-2147. doi:10.1103/physrevlett.60.2144Ng, K.-Y. (1990). Wake fields in a dielectric-lined waveguide. 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Dipole-mode wakefields in dielectric-loaded rectangular waveguide accelerating structures. Physical Review E, 68(1). doi:10.1103/physreve.68.016502Stupakov, G., Bane, K. L. F., & Zagorodnov, I. (2007). Optical approximation in the theory of geometric impedance. Physical Review Special Topics - Accelerators and Beams, 10(5). doi:10.1103/physrevstab.10.054401Hatch, A. J., & Williams, H. B. (1954). The Secondary Electron Resonance Mechanism of Low‐Pressure High‐Frequency Gas Breakdown. Journal of Applied Physics, 25(4), 417-423. doi:10.1063/1.1721656Hatch, A. J., & Williams, H. B. (1958). Multipacting Modes of High-Frequency Gaseous Breakdown. Physical Review, 112(3), 681-685. doi:10.1103/physrev.112.681Vaughan, J. R. M. (1988). Multipactor. IEEE Transactions on Electron Devices, 35(7), 1172-1180. doi:10.1109/16.3387Gilardini, A. L. (1995). Multipacting discharges: Constant‐ktheory and simulation results. Journal of Applied Physics, 78(2), 783-795. doi:10.1063/1.360336Riyopoulos, S. (1997). Multipactor saturation due to space-charge-induced debunching. Physics of Plasmas, 4(5), 1448-1462. doi:10.1063/1.872319Kryazhev, A., Buyanova, M., Semenov, V., Anderson, D., Lisak, M., Puech, J., … Sombrin, J. (2002). Hybrid resonant modes of two-sided multipactor and transition to the polyphase regime. Physics of Plasmas, 9(11), 4736-4743. doi:10.1063/1.1514969Udiljak, R., Anderson, D., Ingvarson, P., Jordan, U., Jostell, U., Lapierre, L., … Sombrin, J. (2003). New method for detection of multipaction. IEEE Transactions on Plasma Science, 31(3), 396-404. doi:10.1109/tps.2003.811646De Lara, J., Perez, F., Alfonseca, M., Galan, L., Montero, I., Roman, E., & Garcia-Baquero, D. R. (2006). Multipactor prediction for on-board spacecraft RF equipment with the MEST software tool. IEEE Transactions on Plasma Science, 34(2), 476-484. doi:10.1109/tps.2006.872450Torregrosa, G., Coves, A., Vicente, C. P., Perez, A. M., Gimeno, B., & Boria, V. E. (2006). Time evolution of an electron discharge in a parallel-plate dielectric-loaded waveguide. IEEE Electron Device Letters, 27(7), 619-621. doi:10.1109/led.2006.877284Udiljak, R., Anderson, D., Lisak, M., Semenov, V. E., & Puech, J. (2007). Multipactor in a coaxial transmission line. I. Analytical study. Physics of Plasmas, 14(3), 033508. doi:10.1063/1.2710464Semenov, V. E., Zharova, N., Udiljak, R., Anderson, D., Lisak, M., & Puech, J. (2007). Multipactor in a coaxial transmission line. II. Particle-in-cell simulations. Physics of Plasmas, 14(3), 033509. doi:10.1063/1.2710466Anza, S., Vicente, C., Gimeno, B., Boria, V. E., & Armendáriz, J. (2007). Long-term multipactor discharge in multicarrier systems. Physics of Plasmas, 14(8), 082112. doi:10.1063/1.2768019Udiljak, R., Anderson, D., Lisak, M., Puech, J., & Semenov, V. E. (2007). Multipactor in a Waveguide Iris. IEEE Transactions on Plasma Science, 35(2), 388-395. doi:10.1109/tps.2007.892737Burton, R. J., de Jong, M. S., & Funk, L. W. (1991). Vacuum and multipactor performance of the hadron electron ring accelerator 52 MHz cavities. Journal of Vacuum Science & Technology A: Vacuum, Surfaces, and Films, 9(3), 2081-2084. doi:10.1116/1.577417Yamaguchi, S., Saito, Y., Anami, S., & Michizono, S. (1992). Trajectory simulation of multipactoring electrons in an S-band pillbox RF window. IEEE Transactions on Nuclear Science, 39(2), 278-282. doi:10.1109/23.277497Kishek, R., & Lau, Y. Y. (1995). Interaction of Multipactor Discharge and rf Circuit. Physical Review Letters, 75(6), 1218-1221. doi:10.1103/physrevlett.75.1218Lay-Kee Ang, Lau, Y. Y., Kishek, R. A., & Gilgenbach, R. M. (1998). Power deposited on a dielectric by multipactor. IEEE Transactions on Plasma Science, 26(3), 290-295. doi:10.1109/27.700756Kishek, R. A., Lau, Y. Y., Ang, L. K., Valfells, A., & Gilgenbach, R. M. (1998). Multipactor discharge on metals and dielectrics: Historical review and recent theories. Physics of Plasmas, 5(5), 2120-2126. doi:10.1063/1.872883Neuber, A., Hemmert, D., Krompholz, H., Hatfield, L., & Kristiansen, M. (1999). Initiation of high power microwave dielectric interface breakdown. Journal of Applied Physics, 86(3), 1724-1728. doi:10.1063/1.370953Chojnacki, E. (2000). Simulations of a multipactor-inhibited waveguide geometry. Physical Review Special Topics - Accelerators and Beams, 3(3). doi:10.1103/physrevstab.3.032001Cimino, R., Collins, I. R., Furman, M. A., Pivi, M., Ruggiero, F., Rumolo, G., & Zimmermann, F. (2004). Can Low-Energy Electrons Affect High-Energy Physics Accelerators? Physical Review Letters, 93(1). doi:10.1103/physrevlett.93.014801Abe, T., Kageyama, T., Akai, K., Ebihara, K., Sakai, H., & Takeuchi, Y. (2006). Multipactoring zone map of an rf input coupler and its application to high beam current storage rings. 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Efficient computation of the 2-D Green’s function for 1-D periodic structures using the Ewald method. IEEE Transactions on Antennas and Propagation, 53(9), 2977-2984. doi:10.1109/tap.2005.854556Kustepeli, A., & Martin, A. Q. (2000). On the splitting parameter in the Ewald method. IEEE Microwave and Guided Wave Letters, 10(5), 168-170. doi:10.1109/75.85036

SUCCOR Nodes: May Sentinel Node Biopsy Determine the Need for Adjuvant Treatment?

Background The SUCCOR cohort was developed to analyse the overall and disease-free survival at 5 years in women with FIGO 2009 stage IB1 cervical cancer. The aim of this study was to compare the use of adjuvant therapy in these women, depending on the method used to diagnose lymphatic node metastasis. Patients and Methods We used data from the SUCCOR cohort, which collected information from 1049 women with FIGO 2009 stage IB1 cervical cancer who were operated on between January 2013 and December 2014 in Europe. We calculated the adjusted proportion of women who received adjuvant therapy depending on the lymph node diagnosis method and compared disease free and overall survival using Cox proportional-hazards regression models. Inverse probability weighting was used to adjust for baseline potential confounders. Results The adjusted proportion of women who received adjuvant therapy was 33.8% in the sentinel node biopsy + lymphadenectomy (SNB+LA) group and 44.7% in the LA group (p = 0.02), although the proportion of positive nodal status was similar (p = 0.30). That difference was greater in women with negative nodal status and positive Sedlis criteria (difference 31.2%, p = 0.01). Here, those who underwent a SNB+LA had an increased risk of relapse [hazard ratio (HR) 2.49, 95% confidence interval (CI) 0.98–6.33, p = 0.056] and risk of death (HR 3.49, 95% CI 1.04–11.7, p = 0.042) compared with those who underwent LA. Conclusions Women in this study were less likely to receive adjuvant therapy if their nodal invasion was determined using SNB+LA compared with LA. These results suggest a lack of therapeutic measures available when a negative result is obtained by SNB+LA, which may have an impact on the risk of recurrence and survival

Analysis of the electromagnetic radiation generated by a multipactor discharge occurring within a microwave passive component

International audienceMultipactoring is a non-linear phenomenon that appears in highpower microwave equipments operating under vacuum conditions and causes several undesirable effects. In this manuscript, a theoretical and experimental study of the RF spectrum radiated by a multipactor discharge, occurring within a realistic microwave component based on rectangular waveguides, is reported. The electromagnetic coupling of a multipactor current to the fundamental propagative mode of a uniform waveguide has been analyzed in the context of the microwave network theory. The discharge produced under a single-carrier RF voltage regime has been approached as a shunt current source exciting such a mode in a transmission-line gap-region. By means of a simple equivalent circuit, this model allows predicting the harmonics generated by the discharge occurring in a realistic passive waveguide component. Power spectrum radiated by a third order multipactor discharge has been measured in an E-plane silver-plated waveguide transformer, thus validating qualitatively the presented theory to simulate the noise generated by a single-carrier multipactor discharge

Study of the Secondary Electron Yield in Dielectrics Using Equivalent Circuital Models

© 2018 IEEE. Personal use of this material is permitted. Permissíon from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertisíng or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.[EN] Secondary electron emission has an important role on the triggering of the multipactor effect; therefore, its study and characterization are essential in radio-frequency waveguide applications. In this paper, we propose a theoretical model, based on equivalent circuit models, to properly understand charging and discharging processes that occur in dielectric samples under electron irradiation for secondary electron emission characterization. Experimental results obtained for Pt, Si, GaS, and Teflon samples are presented to verify the accuracy of the proposed model. Good agreement between theory and experiments has been found.The authors would like to thank the European High Power Space Materials Laboratory for its contribution-a laboratory funded by the European Regional Development Fund-a way of making Europe. Many thanks to the University of Valencia (Spain) for supporting this research activity with the internal program "Assistance for temporary stays of invited researchers within the framework of the Subprogramme Attraction of Talent 2015".Bañón, D.; Socuellamos, JM.; Mata-Sanz, R.; Mercadé-Morales, L.; Gimeno Martínez, B.; Boria Esbert, VE.; Raboso García-Baquero, D.... (2018). Study of the Secondary Electron Yield in Dielectrics Using Equivalent Circuital Models. IEEE Transactions on Plasma Science. 46(4):859-867. https://doi.org/10.1109/TPS.2018.2809602S85986746