1,478 research outputs found
Short report: molecular markers associated with Plasmodium falciparum resistance to sulfadoxine-pyrimethamine in the Democratic Republic of Congo.
Sulfadoxine-pyrimethamine (SP) is the first line antimalarial treatment in the Democratic Republic of Congo. Using polymerase chain reaction, we assessed the prevalence of mutations in the dihydrofolate reductase (dhfr) (codons 108, 51, 59) and dihydropteroate synthase (dhps) (codons 437, 540) genes of Plasmodium falciparum, which have been associated with resistance to pyrimethamine and sulfadoxine, respectively. Four hundred seventy-four patients were sampled in Kilwa (N = 138), Kisangani (N = 112), Boende (N = 106), and Basankusu (N = 118). The proportion of triple mutations dhfr varied between sites but was always > 50%. The proportion of dhps double mutations was < 20%, with some sites as low as 0.9%. A quintuple mutation was present in 12.8% (16/125) samples in Kilwa; 11.9% (13/109) in Kisangani, 2.9% (3/102) in Boende, and 0.9% (1/112) in Basankusu. These results suggest high resistance to pyrimethamine alone or combined with sulfadoxine. Adding artesunate to SP does not seem a valid alternative to the current monotherapy
The Structure and Dynamics of the Upper Chromosphere and Lower Transition Region as Revealed by the Subarcsecond VAULT Observations
The Very high Angular resolution ULtraviolet Telescope (VAULT) is a sounding
rocket payload built to study the crucial interface between the solar
chromosphere and the corona by observing the strongest line in the solar
spectrum, the Ly-a line at 1216 {\AA}. In two flights, VAULT succeeded in
obtaining the first ever sub-arcsecond (0.5") images of this region with high
sensitivity and cadence. Detailed analyses of those observations have
contributed significantly to new ideas about the nature of the transition
region. Here, we present a broad overview of the Ly-a atmosphere as revealed by
the VAULT observations, and bring together past results and new analyses from
the second VAULT flight to create a synthesis of our current knowledge of the
high-resolution Ly-a Sun. We hope that this work will serve as a good reference
for the design of upcoming Ly-a telescopes and observing plans.Comment: 28 pages, 11 figure
First VLTI infrared spectro-interferometry on GCIRS 7 - Characterizing the prime reference source for Galactic center observations at highest angular resolution
Investigating the environment of the massive black hole SgrA* at the center
of the Galaxy requires the highest angular resolution available to avoid source
confusion and to study the physical properties of the individual objects.
GCIRS7 has been used as wavefront and astrometric reference. Our studies
investigate, for the first time, its properties at 2&10um using VLTI/AMBER and
MIDI. We aim at analyzing the suitability of IRS7 as an IF-phase-reference for
the upcoming generation of dual-field facilities at optical interferometers. We
observed with (R~30) and 50m (proj.) baseline, resulting in 9 and 45mas
resolution for NIR and MIR, resp. The first K-band fringe detection of a GC
star suggests that IRS7 could be marginally resolved at 2um, which would imply
that the photosphere of the supergiant is enshrouded by a molecular and dusty
envelope. At 10um, IRS7 is strongly resolved with a visibility of approximately
0.2. The MIR is dominated by moderately warm (200 K), extended dust, mostly
distributed outside of a radius of about 120 AU (15 mas) around the star. A
deep 9.8-silicate absorption in excess of the usual extinction law with respect
to the NIR extinction has been found. This confirms recent findings of a
relatively enhanced, interstellar 9.8-silicate absorption with respect to the
NIR extinction towards another star in the central arcsec, suggesting an
unusual dust composition in that region. Our VLTI observations show that
interferometric NIR phase-referencing experiments with mas resolution using
IRS7 as phase-reference appear to be feasible, but more such studies are
required to definitely characterize the close environment around this star. We
demonstrate that interferometry is required to resolve the innermost
environment of stars at the Galactic center.Comment: 6 pages, 2 figures, accepted for publication in A&
Automatic eduction and statistical analysis of coherent structures in the wall region of a confine plane
This paper describes a vortex detection algorithm used to expose and statistically characterize the
coherent flow patterns observable in the velocity vector fields measured by Particle Image
Velocimetry (PIV) in the impingement region of air curtains. The philosophy and the architecture of
this algorithm are presented. Its strengths and weaknesses are discussed. The results of a
parametrical analysis performed to assess the variability of the response of our algorithm to the 3
user-specified parameters in our eduction scheme are reviewed. The technique is illustrated in the
case of a plane turbulent impinging twin-jet with an opening ratio of 10. The corresponding jet
Reynolds number, based on the initial mean flow velocity U0 and the jet width e, is 14000. The
results of a statistical analysis of the size, shape, spatial distribution and energetic content of the
coherent eddy structures detected in the impingement region of this test flow are provided.
Although many questions remain open, new insights into the way these structures might form,
organize and evolve are given. Relevant results provide an original picture of the plane turbulent
impinging jet
Anomalous Couplings in Double Higgs Production
The process of gluon-initiated double Higgs production is sensitive to
non-linear interactions of the Higgs boson. In the context of the Standard
Model, studies of this process focused on the extraction of the Higgs trilinear
coupling. In a general parametrization of New Physics effects, however, an even
more interesting interaction that can be tested through this channel is the
(ttbar hh) coupling. This interaction vanishes in the Standard Model and is a
genuine signature of theories in which the Higgs boson emerges from a
strongly-interacting sector. In this paper we perform a model-independent
estimate of the LHC potential to detect anomalous Higgs couplings in
gluon-fusion double Higgs production. We find that while the sensitivity to the
trilinear is poor, the perspectives of measuring the new (ttbar hh) coupling
are rather promising.Comment: 22 pages, 9 figures. v2: plots of Figs.8 and 9 redone to include
experimental uncertainty on the Higgs couplings, references adde
Meson Form Factors and Non-Perturbative Gluon Propagators
The meson (pion and kaon) form factor is calculated in the perturbative
framework with alternative forms for the running coupling constant and the
gluon propagator in the infrared kinematic region. These modified forms are
employed to test the sensibility of the meson form factor to the
nonperturbative contributions. Its is a powerful discriminating quantity and
the results obtained with a particular choice of modified running coupling
constant and gluon propagator have a good agreement with the available data,
for both mesons, indicating the robustness of the method of calculation.
Nevertheless, nonperturbative aspects may be included in the perturbative
framework of calculation of exclusive processes.Comment: 18 pages, 7 figures. Discutions added, clarifing figures. Accepted to
be published in Phys. Rev.
Running coupling in Yang-Mills theory - a flow equation study -
The effective average action of Yang-Mills theory is analyzed in the
framework of exact renormalization group flow equations. Employing the
background-field method and using a cutoff that is adjusted to the spectral
flow, the running of the gauge coupling is obtained on all scales. In four
dimensions and for the gauge groups SU(2) and SU(3), the coupling approaches a
fixed point in the infrared.Comment: 35 pages, 3 figures, v2: References added, minor improvements,
version to appear in PR
On the Infrared Exponent for Gluon and Ghost Propagation in Landau Gauge QCD
In the covariant description of confinement, one expects the ghost
correlations to be infrared enhanced. Assuming ghost dominance, the long-range
behavior of gluon and ghost correlations in Landau gauge QCD is determined by
one exponent kappa. The gluon propagator is infrared finite (vanishing) for
kappa =1/2 (kappa > 1/2) which is still under debate. Here, we study critical
exponent and coupling for the infrared conformal behavior from the asymptotic
form of the solutions to the Dyson-Schwinger equations in an ultraviolet finite
expansion scheme. The value for kappa is directly related to the ghost-gluon
vertex. Assuming that it is regular in the infrared, one obtains kappa = 0.595.
This value maximizes the critical coupling alpha_c(kappa), yielding alpha_c^max
= (4 Pi/Nc) 0.709 approx. 2.97 for Nc=3. For larger kappa the vertex acquires
an infrared singularity in the gluon momentum, smaller ones imply infrared
singular ghost legs. Variations in alpha_c remain within 5% from kappa = 0.5 to
0.7. Above this range, alpha_c decreases more rapidly with alpha_c -> 0 as
kappa -> 1 which sets the upper bound on kappa.Comment: 22 Pages, 10 Figures, LaTeX2e, revtex4, some notes and references
added in response to communication
Analytic properties of the Landau gauge gluon and quark propagators
We explore the analytic structure of the gluon and quark propagators of
Landau gauge QCD from numerical solutions of the coupled system of renormalized
Dyson--Schwinger equations and from fits to lattice data. We find sizable
negative norm contributions in the transverse gluon propagator indicating the
absence of the transverse gluon from the physical spectrum. A simple analytic
structure for the gluon propagator is proposed. For the quark propagator we
find evidence for a mass-like singularity on the real timelike momentum axis,
with a mass of 350 to 500 MeV. Within the employed Green's functions approach
we identify a crucial term in the quark-gluon vertex that leads to a positive
definite Schwinger function for the quark propagator.Comment: 42 pages, 16 figures, revtex; version to be published in Phys Rev
Optimized isolation of 7,7âČ-biphyscion starting from Cortinarius rubrophyllus, a chemically unexplored fungal species rich in photosensitizers
Mushrooms such as the dermocyboid Cortinarius rubrophyllus are characterized by strikingly colorful fruiting bodies. The molecular dyes responsible for such colors recently experienced a comeback as photoactive compounds with remarkable photophysical and photobiological properties. One of them-7,7'-biphyscion-is a dimeric anthraquinone that showed promising anticancer effects in the low nanomolar range under blue-light irradiation. Compared to acidic anthraquinones, 7,7'-biphyscion was more efficiently taken up by cells and induced apoptosis after photoactivation. However, seasonal collection of mushrooms producing this compound, low extraction yields, and tricky fungal identification hamper further developments to the clinics. To bypass these limitations, we demonstrate here an alternative approach utilizing a precursor of 7,7'-biphyscion, i.e., the pre-anthraquinone flavomannin-6,6'-dimethyl ether, which is abundant in many species of the subgenus Dermocybe. Controlled oxidation of the crude extract significantly increased the yield of 7,7'-biphyscion by 100%, which eased the isolation process. We also present the mycochemical and photobiological characterization of the yet chemically undescribed species, i.e. C. rubrophyllus. In total, eight pigments (1-8) were isolated, including two new glycosylated anthraquinones (1 and 2). Light-dependent generation of singlet oxygen was detected for the first time for emodin-1-O-beta-D-glucopyranoside (3) [photophysical measurement: Phi(Delta) =0.11 (CD3OD)]. Furthermore, emodin (7) was characterized as promising compound in the photocytotoxicity assay with EC50-values in the low micromolar range under irradiation against cells of the cancer cell lines AGS, A549, and T24.Metals in Catalysis, Biomimetics & Inorganic Material
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