The Dunhuang chinese sky: a comprehensive study of the oldest known star atlas

This paper presents an analysis of the star atlas included in the medieval Chinese manuscript (Or.8210/S.3326), discovered in 1907 by the archaeologist Aurel Stein at the Silk Road town of Dunhuang and now held in the British Library. Although partially studied by a few Chinese scholars, it has never been fully displayed and discussed in the Western world. This set of sky maps (12 hour angle maps in quasi-cylindrical projection and a circumpolar map in azimuthal projection), displaying the full sky visible from the Northern hemisphere, is up to now the oldest complete preserved star atlas from any civilisation. It is also the first known pictorial representation of the quasi-totality of the Chinese constellations. This paper describes the history of the physical object - a roll of thin paper drawn with ink. We analyse the stellar content of each map (1339 stars, 257 asterisms) and the texts associated with the maps. We establish the precision with which the maps are drawn (1.5 to 4 degrees for the brightest stars) and examine the type of projections used. We conclude that precise mathematical methods were used to produce the atlas. We also discuss the dating of the manuscript and its possible author and confirm the dates 649-684 (early Tang dynasty) as most probable based on available evidence. This is at variance with a prior estimate around +940. Finally we present a brief comparison with later sky maps, both in China and in Europe.Comment: 19 pages, 5 Tables, 8 Figure

Immunisation of migrants in EU/EEA countries: Policies and practices

In recent years various EU/EEA countries have experienced an influx of migrants from low and middle-income countries. In 2018, the “Vaccine European New Integrated Collaboration Effort (VENICE)” survey group conducted a survey among 30 EU/EEA countries to investigate immunisation policies and practices targeting irregular migrants, refugees and asylum seekers (later called “migrants” in this report). Twenty-nine countries participated in the survey. Twenty-eight countries reported having national policies targeting children/adolescent and adult migrants, however vaccinations offered to adult migrants are limited to specific conditions in seven countries. All the vaccinations included in the National Immunisation Programme (NIP) are offered to children/adolescents in 27/28 countries and to adults in 13/28 countries. In the 15 countries offering only certain vaccinations to adults, priority is given to diphtheria-tetanus, measles-mumps-rubella and polio vaccinations. Information about the vaccines given to child/adolescent migrants is recorded in 22 countries and to adult migrants in 19 countries with a large variation in recording methods found across countries. Individual and aggregated data are reportedly not shared with other centres/institutions in 13 and 15 countries, respectively. Twenty countries reported not collecting data on vaccination uptake among migrants; only three countries have these data at the national level. Procedures to guarantee migrants’ access to vaccinations at the community level are available in 13 countries. In conclusion, although diversified, strategies for migrant vaccination are in place in all countries except for one, and the strategies are generally in line with international recommendations. Efforts are needed to strengthen partnerships and implement initiatives across countries of origin, transit and destination to develop and better share documentation in order to guarantee a completion of vaccination series and to avoid unnecessary re-vaccination. Development of migrant-friendly strategies to facilitate migrants' access to vaccination and collection of vaccination uptake data among migrants is needed to meet existing gaps

Predictors of hospital discharge and mortality in patients with diabetes and COVID-19: updated results from the nationwide CORONADO study

AIMS/HYPOTHESIS: This is an update of the results from the previous report of the CORONADO (Coronavirus SARS-CoV-2 and Diabetes Outcomes) study, which aims to describe the outcomes and prognostic factors in patients with diabetes hospitalised for coronavirus disease-2019 (COVID-19). METHODS: The CORONADO initiative is a French nationwide multicentre study of patients with diabetes hospitalised for COVID-19 with a 28-day follow-up. The patients were screened after hospital admission from 10 March to 10 April 2020. We mainly focused on hospital discharge and death within 28 days. RESULTS: We included 2796 participants: 63.7% men, mean age 69.7 ± 13.2 years, median BMI (25th-75th percentile) 28.4 (25.0-32.4) kg/m(2). Microvascular and macrovascular diabetic complications were found in 44.2% and 38.6% of participants, respectively. Within 28 days, 1404 (50.2%; 95% CI 48.3%, 52.1%) were discharged from hospital with a median duration of hospital stay of 9 (5-14) days, while 577 participants died (20.6%; 95% CI 19.2%, 22.2%). In multivariable models, younger age, routine metformin therapy and longer symptom duration on admission were positively associated with discharge. History of microvascular complications, anticoagulant routine therapy, dyspnoea on admission, and higher aspartate aminotransferase, white cell count and C-reactive protein levels were associated with a reduced chance of discharge. Factors associated with death within 28 days mirrored those associated with discharge, and also included routine treatment by insulin and statin as deleterious factors. CONCLUSIONS/INTERPRETATION: In patients with diabetes hospitalised for COVID-19, we established prognostic factors for hospital discharge and death that could help clinicians in this pandemic period. TRIAL REGISTRATION: Clinicaltrials.gov identifier: NCT04324736

Research response to coronavirus disease 2019 needed better coordination and collaboration: a living mapping of registered trials

Objectives: Researchers worldwide are actively engaging in research activities to search for preventive and therapeutic interventions against coronavirus disease 2019 (COVID-19). Our aim was to describe the planning of randomized controlled trials (RCTs) in terms of timing related to the course of the COVID-19 epidemic and research question evaluated. Study Design and Setting: We performed a living mapping of RCTs registered in the WHO International Clinical Trials Registry Platform. We systematically search the platform every week for all RCTs evaluating preventive interventions and treatments for COVID-19 and created a publicly available interactive mapping tool at https://covid-nma.com to visualize all trials registered. Results: By August 12, 2020, 1,568 trials for COVID-19 were registered worldwide. Overall, the median ([Q1–Q3]; range) delay between the first case recorded in each country and the first RCT registered was 47 days ([33–67]; 15–163). For the 9 countries with the highest number of trials registered, most trials were registered after the peak of the epidemic (from 100% trials in Italy to 38% in the United States). Most trials evaluated treatments (1,333 trials; 85%); only 223 (14%) evaluated preventive strategies and 12 postacute period intervention. A total of 254 trials were planned to assess different regimens of hydroxychloroquine with an expected sample size of 110,883 patients. Conclusion: This living mapping analysis showed that COVID-19 trials have relatively small sample size with certain redundancy in research questions. Most trials were registered when the first peak of the pandemic has passed

Position taxonomique de divers mollicutes et etude d'organismes de ce type (MLO) par hybridation ADN-ADN

SIGLECNRS T Bordereau / INIST-CNRS - Institut de l'Information Scientifique et TechniqueFRFranc

CONDITIONS DE TRAVAIL ET SANTE DES AIDES A DOMICILE (ENQUETE AUPRES D'UNE ASSOCIATION DE LOIRE-ATLANTIQUE (DES MEDECINE DU TRAVAIL))

NANTES-BU Médecine pharmacie (441092101) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

Academics - an uncertain professional identity

University professions have considerably changed over the last few decades. In addition to teaching and research there are now many administrative and representative activities. The academic profession is still divided into hierarchies, statuses and disciplines with different practices and values and this does not contribute to a common identity. As the required duties are now almost only a certain amount of teaching hours per year, everybody works very differently according to their temperament, discipline, status, sex, age and so forth. A loss of prestige for intellectual professions is more crucial for French academics because outside the Universities there are great research bodies like the CNRS and INSERM and prestigious schools ("Grandes Ecoles").Université Paris X-Nanterre, FRALa profession d'universitaire a considérablement changé en quelques décennies : au double métier d'enseignant et de chercheur, se sont ajoutées de multiples activités administratives et représentatives. La profession reste hiérarchisée en de multiples statuts, et morcelée en disciplines ayant chacune des pratiques et des valeurs différentes, ce qui ne contribue pas à constituer une identité commune. Comme les obligations professionnelles se réduisent quasiment à un nombre d'heures d'enseignement, chacun s'investit de façon très inégale selon son tempérament, sa discipline, son statut, son sexe, son âge... La perte de prestige des professions intellectuelles actuelle est d'autant plus mal vécue par les universitaires français qu'il existe hors de l'Université de grands organismes de recherche (CNRS, INSERM...) et des institutions d'enseignement prestigieuses (les Grandes Écoles)