What can fertility indicators tell us about pronatalist policy options?

The identification and implementation of ways to avert the adverse future consequences of rapid population ageing represent urgent new public policy challenges. This paper synthesises the available knowledge on pronatalist policy options and assesses their potential impact by examining three fertility indicators: the total fertility rate, the tempo-adjusted total fertility rate and the personal ideal family size. Using recent data from thirteen European countries, the TFR is found to be lower than the ideal family size in each population. The two main reasons for this gap are tempo effects and economic, social and biological obstacles to the implementation of reproductive preferences. These factors together are estimated to average approximately 0.8 to 0.9 births per woman. Policy options to raise fertility without interfering with existing reproductive preferences are proposed. The concluding section briefly examines the impact of an increase in fertility on future trends in the old-age dependency ratio.

Five period measures of longevity

This study provides a summary of recently proposed alternatives period measures of "longevity" and assesses whether empirical differences between these measures are consistent with predictions from analytic studies. Particular attention is given to the tempo effect. Three of the five period measures are virtually equal to one another in a simulated population in which mortality follows a Gompertz model with a constant rate of improvement. Similar results are observed among females in Denmark, England and Wales and Sweden in the last quarter century. However, these three measures differ substantially from the conventional period life expectancy when mortality changes over time. These findings are consistent with theoretical analysis by Bongaarts and Feeney (2002, 2003, 2005) which demonstrated that this deviation is caused by a tempo effect whose size varies with the rate of change in mortality.life expectancy, longevity, measures, period, tempo distortion

The causes of educational differences in fertility in Sub-Saharan Africa

This study first presents an analytic framework that describes the chain of causation linking fertility to its multiple layers of determinants. Next, this framework is applied to analyse the causes of educational fertility differences in 30 sub-Saharan African countries using data from DHS surveys. The results demonstrate that education levels are positively associated with demand for and use of contraception and negatively associated with fertility and desired family size. In addition, there are differences by level of education in the relationships between indicators. As education rises, fertility is lower at a given level of contraceptive use, contraceptive use is higher at a given level of demand, and demand is higher at a given level of desired family size. The most plausible explanations for these shifting relationships are that better-educated women marry later and less often, use contraception more effectively, have more knowledge about and access to contraception, have greater autonomy in reproductive decision-making, and are more motivated to implement demand because of the higher opportunity costs of unintended childbearing.

The Quantum and Tempo of Life-Cycle Events

This study develops and applies a general framework for the analysis of the period quantum and tempo of life-cycle events, extending methods developed previously by the authors. The existence of tempo distortions is demonstrated in selected period quantum measures such as the total fertility rate and in period tempo measures such as life expectancy. A tempo distortion is defined as an inflation or deflation of a period quantum or tempo indicator of a life-cycle event, such as birth, marriage, or death, that results from a rise or fall in the mean age at which the event occurs. Period measures derived from life tables are also found to be subject to tempo distortions. Methods to remove these tempo distortions are then developed and applied.

Edinger-Westphal Nucleus

This report contains a summary of expression patterns for genes that are enriched in the Edinger-Westphal nucleus (EW) of the midbrain. All data are derived from the Allen Brain Atlas (ABA) in situ hybridization mouse project. The structure's location and morphological characteristics in the mouse brain are described using the Nissl data found in the Allen Reference Atlas. Using an established algorithm, the expression values of the Edinger-Westphal nucleus were compared to the values of its larger parent structure, in this case the midbrain, for the purpose of extracting regionally selective gene expression data. The highest ranking genes were manually curated and verified. 50 genes were then selected and compiled for expression analysis. The experimental data for each gene may be accessed via the links provided; additional data in the sagittal plane may also be accessed using the ABA. Correlations between gene expression in the Edinger-Westphal nucleus and the rest of the brain, across all genes in the coronal dataset (~4300 genes), were derived computationally. A gene ontology table (derived from DAVID Bioinformatics Resources 2007) is also included, highlighting possible functions of the 50 genes selected for this report. 
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Anterior Olfactory Nucleus

This report contains a gene expression summary of the anterior olfactory nucleus (AON), derived from the Allen Brain Atlas (ABA) in situ hybridization mouse data set. The structure's location and morphological characteristics in the mouse brain are described using the Nissl data found in the Allen Reference Atlas. Using an established algorithm, the expression values of the AON were compared to the values of the macro/parent-structure, in this case the olfactory areas, for the purpose of extracting regionally selective gene expression data. The genes with the highest ranking selectivity ratios were manually curated and verified. 50 genes were then selected and compiled for expression characterization. The experimental data for each gene may be accessed via the links provided; additional data in the sagittal plane may also be accessed using the ABA. Correlations between gene expression in the AON and the rest of the brain, across all genes in the coronal dataset (~4300 genes), were derived computationally. A gene ontology table (derived from DAVID Bioinformatics Resources 2007) is also included, highlighting possible functions of the 50 genes selected for this report

Oculomotor Nucleus

This report contains a gene expression summary of the oculomotor nucleus, derived from the Allen Brain Atlas (ABA) in situ hybridization mouse data set. The structure's location and morphological characteristics in the mouse brain are described using the Nissl data found in the Allen Reference Atlas. Using an established algorithm, the expression values of the oculomotor nucleus were compared to the values of the macro/parent-structure, in this case the midbrain, for the purpose of extracting regionally selective gene expression data. The genes with the highest ranking selectivity ratios were manually curated and verified. 50 genes were then selected and compiled for expression characterization. The experimental data for each gene may be accessed via the links provided; additional data in the sagittal plane may also be accessed using the ABA. Correlations between gene expression in the oculomotor nucleus and the rest of the brain, across all genes in the coronal dataset (~4300 genes), were derived computationally. A gene ontology table (derived from DAVID Bioinformatics Resources 2007) is also included, highlighting possible functions of the 50 genes selected for this report

Dentate Gyrus

This report contains a gene expression summary of the dentate gyrus (DG), derived from the Allen Brain Atlas (ABA) _in situ_ hybridization mouse data set. The structure's location and morphological characteristics in the mouse brain are described using the Nissl data found in the Allen Reference Atlas. Using an established algorithm, the expression values of the dentate gyrus were compared to the values of the macro/parent-structure, in this case the hippocampal region, for the purpose of extracting regionally selective gene expression data. The genes with the highest ranking selectivity ratios were manually curated and verified. 50 genes were then selected and compiled for expression characterization. The experimental data for each gene may be accessed via the links provided; additional data in the sagittal plane may also be accessed using the ABA. Correlations between gene expression in the dentate gyrus and the rest of the brain, across all genes in the coronal dataset (~4300 genes), were derived computationally. A gene ontology table (derived from DAVID Bioinformatics Resources 2007) is also included, highlighting possible functions of the 50 genes selected for this report

Motor Nucleus of the Trigeminal Nerve

This report contains a summary of expression patterns for genes that are enriched in the motor nucleus of the trigeminal nerve (V) of the pons. All data is derived from the Allen Brain Atlas (ABA) in situ hybridization mouse project. The structure's location and morphological characteristics in the mouse brain are described using the Nissl data found in the Allen Reference Atlas. Using an established algorithm, the expression values of the motor nucleus of the trigeminal nerve were compared to the values of its larger parent structure, in this case the pons, for the purpose of extracting regionally selective gene expression data. The highest ranking genes were manually curated and verified. 50 genes were then selected and compiled for expression analysis. The experimental data for each gene may be accessed via the links provided; additional data in the sagittal plane may also be accessed using the ABA. Correlations between gene expression in the motor nucleus of the trigeminal nerve and the rest of the brain, across all genes in the coronal dataset (~4300 genes), were derived computationally. A gene ontology table (derived from DAVID Bioinformatics Resources 2007) is also included, highlighting possible functions of the 50 genes selected for this report. 
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Cerebellar Cortex, Purkinje Cell Layer

This report contains a summary of expression patterns for genes that are enriched in the Purkinje cell layer (CBXpu) of the cerebellum. All data is derived from the Allen Brain Atlas (ABA) in situ hybridization mouse project. The structure's location and morphological characteristics in the mouse brain are described using the Nissl data found in the Allen Reference Atlas. Using an established algorithm, the expression values of the CBXpu were compared to the values of its larger parent structure, in this case the cerebellar cortex, for the purpose of extracting regionally selective gene expression data. The highest ranking genes were manually curated and verified. 50 genes were then selected and compiled for expression analysis. The experimental data for each gene may be accessed via the links provided; additional data in the sagittal plane may also be accessed using the ABA. A gene ontology table (derived from DAVID Bioinformatics Resources 2007) is also included, highlighting possible functions of the 50 genes selected for this report. 
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