Hematopoietic Stem Cell Transplantation in Primary Immunodeficiencies in Brazil-a Survey of the Working Group on Paediatric Transplantation of the Brazilian Society of Bone Marrow Transplantation

Inst Crianca HCFMUSP, Sao Paulo, BrazilHosp Israelita Albert Einstein, Sao Paulo, BrazilInst Oncol Pediat, Sao Paulo, BrazilHosp Clin Porto Alegre, Porto Alegre, RS, BrazilUniv Fed Parana, Bone Marrow Transplantat Unit, BR-80060000 Curitiba, Parana, BrazilCtr Oncol & Hematol, Jau, BrazilUSP Ribeirao Preto, Hosp Clin, Ribeirao Preto, BrazilUniv Fed Minas Gerais, Belo Horizonte, MG, BrazilUniv Fed Rio de Janeiro, Rio De Janeiro, BrazilCtr Nacl Transplate Medula Ossea CEMO, Inst Nacl Canc, Rio De Janeiro, BrazilUniv Fed Parana, Paediat Intens Care Unit, BR-80060000 Curitiba, Parana, BrazilNatl Inst Canc INCA, Rio De Janeiro, BrazilHosp Israelita Albert Einstein, Hematol & Bone Marrow Transplantat Dept, Sao Paulo, BrazilWeb of Scienc

Ionization and Fragmentation of a Global Warming Gas by EUV and X-Ray Photons

An experimental investigation of the processes leading tothe fragmentation of the singly ionized 1,1,1,2-tetrafluoroethane (HFC-134a, CH2FCF3) by EUV and soft X-rays is presented. HFC-134ais taken into consideration as the most convenient replacement for CFC-12 in refrigeration applications due to the fact that it has null ozone depletion factor. Dissociation of the singly ionized HFC-134amolecule was induced by valence, direct and indirect C 1s core photoionization or photoexcitation and the ionic fragments were detected in coincidence (PEPICO mode) with the ejected electrons without energy analysis. The singly ionized parent ion CF4CH2+can be detected even at photon energies above the C 1s threshold

Correction: Topical HPMC/S-Nitrosoglutathione Solution Decreases Inflammation and Bone Resorption in Experimental Periodontal Disease in Rats.

[This corrects the article DOI: 10.1371/journal.pone.0153716.]

Epidemic Spread of SARS-CoV-2 Lineage B.1.1.7 in Brazil

The emergence of diverse lineages harboring mutations with functional significance and potentially enhanced transmissibility imposes an increased difficulty on the containment of the SARS-CoV-2 pandemic [...

Representative examples of iNOS (1^st row), RANK (2^nd row) and TRAP (3^rd row) immunostainning in experimental periodontitis in rats.

<p>Staining was performed using periodontal tissues from normal control animals (b, g, l, q), animals subjected to experimental periodontitis that received topical applications of HPMC (c, h, m, r) or 10 mM HPMC/GSNO (d, i, n, s). Negative controls were samples of periodontal tissue where the primary antibody was replaced with PBS-BSA (5%); no immunostaining was detected (a, f, k, p). Magnification x200. Arrows points to immunostaining osteoclasts in the periodontal tissue of the control HPMC solution group (Magnification x1000).</p

Effect of topical application of HPMC/GSNO solutions on alveolar bone loss in experimental periodontitis.

<p>Data represent the mean ± SEM of six animals in each group. #P<0.05 was considered significantly different compared to the normal control group (NORMAL); *P<0.05 was considered significantly different compared to rats subjected to experimental periodontitis, which received topical application of the vehicle (HPMC). (ANOVA; Bonferroni’s test).</p

Topical HPMC/S-Nitrosoglutathione Solution Decreases Inflammation and Bone Resorption in Experimental Periodontal Disease in Rats - Fig 2

<p><b>Effect of topical application of HPMC/GSNO solutions on the macroscopic (first column) and histological (second column) aspects of periodontium (A and B)</b> normal maxilla, showing integrity of its components (c. Cementum, pl. Periodontal ligament, ab. Alveolar bone and g. Gingiva). (<b>C and D)</b> Maxilla subjected to experimental periodontitis that received just the vehicle (HPMC), showing severe bone resorption, inflammatory infiltrate in both the gingiva and periodontal ligament, extensive cementum destruction and total resorption of the alveolar process, (<b>E and F)</b> Maxilla after 11 days of experimental periodontitis treated with 2.0 mM HPMC/GSNO showing discrete cell influx and preservation of the alveolar process and cementum. Picrosirius staining (magnification x40).</p