Autism Spectrum Disorder: How Parents use Behavior Modification With Their Children

This qualitative research study explores how parents use behavior modifications with their children diagnosed with autism spectrum disorder. Seven participants, who are mothers of children diagnosed with autism, were interviewed for this study. This research found that essentially, parents use different techniques applied in various ways in specific situations based on the uniqueness of their child and the behaviors displayed. Several themes emerged from this study which includes: challenging behaviors, behavior modifications used, behavior modification becomes a way of life, the need to individualize behavior modifications, behavior modifications will change as the child changes, challenges of having a child with autism, coping strategies, advice to professionals, and finding the joys. The respondents displayed creativity and resiliency in their use of behavior modifications for their children. The challenging behaviors displayed varied among different types of behaviors such as sensory-related, verbally and physically aggressive conduct, lack of social skills, and obsessive behaviors. Additionally, each child had unique characteristics which required techniques to be tailored to him/her. This research study provides further implications to social work practice, in that autism spectrum disorder affects the entire family and supports and resources should encompass the system as a whole. Additionally, social workers must stay abreast on the newest research regarding autism spectrum disorder to provide the best practices

Autism Spectrum Disorder: How Parents use Behavior Modification With Their Children

This qualitative research study explores how parents use behavior modifications with their children diagnosed with autism spectrum disorder. Seven participants, who are mothers of children diagnosed with autism, were interviewed for this study. This research found that essentially, parents use different techniques applied in various ways in specific situations based on the uniqueness of their child and the behaviors displayed. Several themes emerged from this study which includes: challenging behaviors, behavior modifications used, behavior modification becomes a way of life, the need to individualize behavior modifications, behavior modifications will change as the child changes, challenges of having a child with autism, coping strategies, advice to professionals, and finding the joys. The respondents displayed creativity and resiliency in their use of behavior modifications for their children. The challenging behaviors displayed varied among different types of behaviors such as sensory-related, verbally and physically aggressive conduct, lack of social skills, and obsessive behaviors. Additionally, each child had unique characteristics which required techniques to be tailored to him/her. This research study provides further implications to social work practice, in that autism spectrum disorder affects the entire family and supports and resources should encompass the system as a whole. Additionally, social workers must stay abreast on the newest research regarding autism spectrum disorder to provide the best practices

Nest cover and faecal glucocorticoid metabolites are linked to hatching success and telomere length in breeding Common Eiders (Somateria mollissima)

Habitat-associated crypsis may affect perceived predation vulnerability, selecting for different predator avoidance strategies. Glucocorticoids could mediate the adjustment of escape responses to the extent of crypsis, introducing an overlooked source of variation in glucocorticoid-fitness relationships. However, prolonged exposure to elevated glucocorticoids may be costly, leading to accelerated telomere loss and, consequently, senescence. Here, we examined how nest cover and immunoreactive faecal glucocorticoid metabolite (fGCM) levels are linked to hatching success and telomere length in breeding female Common Eiders (Somateria mollissima (L., 1758)). We hypothesized that the degree of nest crypsis, reflecting differences in perceived predation risk, would moderate the relationship between reproductive success and fGCM levels. We also expected that telomere length would be shorter in birds with higher glucocorticoid concentration. Results showed that individuals with high fGCM levels had higher hatching success in nests with low cover, while low fGCM levels were more successful in well-concealed nests. We found that shorter telomeres were associated with high fGCM in nesting sites offering little cover and with low fGCM in well-concealed ones. This study provides the first evidence of habitat-dependent moderation of the relationships between stress physiology, telomere length and hatching success.Peer reviewe

Short term efficacy of nebulized beclomethasone in mild-to-moderate wheezing episodes in pre-school children

<p>Abstract</p> <p>Background</p> <p>Few data are available on the usefulness of short term treatment with low-medium dose of inhaled corticosteroids (ICS) in pre-school children with wheezing exacerbations.</p> <p>Methods</p> <p>To compare the efficacy of one week treatment with 400 μg b.i.d. nebulized beclomethasone dipropionate (BDP), plus nebulized 2500 μg prn salbutamol (BDP group), versus nebulized b.i.d. placebo, plus nebulized prn 2500 μg salbutamol (placebo group), a post-hoc analysis was performed on data obtained in 166 pre-school children with multiple-trigger wheezing, recruited during an acute wheezing episode.</p> <p>Results</p> <p>The percentage of symptom-free days (SFDs) was significantly higher in the BDP group (54.7%) than in the placebo group (40.5%; p = 0.012), with a 35% relative difference. Day-by-day analysis showed that the percentage of SFDs was already higher in the BDP group after 2 days (7.4%), the difference reaching statistical significance at day 6 (12.3%; p = 0.035). Cough score was also reduced in the BDP group (0.11) as compared with the placebo group (0.39; p = 0.048), the difference reaching statistical significance after 5 days of treatment (0.18 and 0.47 respectively; p = 0.047). The mean number of nebulizations per day of prn salbutamol was lower in the BDP group as compared to the placebo group (0.26 and 0.34, respectively), but the difference was not significant (p = 0.366). There were no differences in positive effects of BDP treatment between children with and without risk factors for asthma.</p> <p>Conclusions</p> <p>A 1-week treatment with nebulized BDP and prn salbutamol is effective in increasing SFDs and improving cough in children with wheezing, providing a clinical rationale for the short term use of ICS in episodic wheeze exacerbations in pre-school children.</p> <p>Trial Registration</p> <p>ClinicalTrials.gov (<a href="http://www.clinicaltrials.gov/ct2/show/NCT00497523">NCT00497523</a>)</p

Flunisolide Decreases Exhaled Nitric Oxide and Nitrotyrosine Levels in Asthmatic Children

Background. Exhaled nitric oxide (FeNO) has been reported to be elevated in the oxidative stress involved in asthmatic patients, and the reaction of nitric oxide (NO) with superoxide anions results in the formation of nitrotyrosine. The purpose of this study was to investigate the effect of inhaled steroid treatment on nitrotyrosine levels collected by exhaled breath condensate (EBC) and on FeNO. Methods. This was a single-blind placebo-controlled study. The lung function, FeNO, and nitrotyrosine levels were evaluated in 10 asthmatic children. Results. The nitrotyrosine levels were stable during the placebo period (T0 = 1.16 ng/ml versus T1 = 1.05 ng/ml; NS.), whereas they decreased after the treatment with flunisolide (T2 = 1.14 ng/ml versus T3 = 0.88 ng/ml; P < .001). No significant reduction in FeNO levels was observed after placebo treatment (T0 = 38.4 ppb versus T1 = 34.7 ppb, NS.). In contrast, FeNO values decreased significantly being at T3 = 14.9 ppb (T1 versus T3; P = .024). Conclusions. This study shows that corticosteroid treatment reduces nitrotyrosine levels in EBC of asthmatic subjects

Probabilistic movement model with emigration simulates movements of deer in Nebraska, 1990–2006

Movements of deer can affect population dynamics, spatial redistribution, and transmission and spread of diseases. Our goal was to model the movement of deer in Nebraska in an attempt to predict the potential for spread of chronic wasting disease (CWD) into eastern Nebraska. We collared and radio-tracked \u3e600 white-tailed deer (Odocoileus virginianus) and mule deer (Odocoileus hemionus) in Nebraska during 1990–2006.We observed large displacements (\u3e10 km) for both species and sexes of deer, including migrations up to 100 km and dispersals up to 50 km. Average distance traveled between successive daily locations was 166m for male and 173 for female deer in eastern Nebraska, and 427m for male and 459 for female deer in western Nebraska. Average daily displacement from initial capture point was 10m for male and 14m for female deer in eastern Nebraska, and 27m for male and 28m for female deer in western Nebraska.We used these data on naturally occurring movements to create and test 6 individual-based models of movement for white-tailed deer and mule deer in Nebraska, including models that incorporated sampling from empirical distributions of movement lengths and turn angles (DIST), correlated random walks (CRW), home point fidelity (FOCUS), shifting home point (SHIFT), probabilistic movement acceptance (MOVE), and probabilistic movement with emigration (MOVEwEMI). We created models in sequence in an attempt to account for the shortcomings of the previous model(s). We used the Kolmogrov–Smirnov goodness-of-fit test to verify improvement of simulated annual displacement distributions to empirical displacement distributions. The best-fit model (D = 0.07 and 0.08 for eastern and western Nebraska, respectively) included a probabilistic-movement chance with emigration (MOVEwEMI) and resulted in an optimal daily movement length of 350m (maximum daily movement length of 2800m for emigrators) for eastern Nebraska and 370m (maximum of 2960m) for western Nebraska. The proportion of deer that moved as emigrators was 0.10 and 0.13 for eastern and western Nebraska, respectively. We propose that the observed spread of CWD may be driven by large movements of a small proportion of deer that help to establish a low prevalence of the disease in areas east of the current endemic area. Our movement models will be used in a larger individual-based simulation of movement, survival, and transmission of CWD to help determine future surveillance and management actions

Safety and efficacy of fluticasone propionate in the topical treatment of skin diseases

Fluticasone propionate - the first carbothioate corticosteroid - has been classified as a potent anti-inflammatory drug for dermatological use. It is available as 0.05% cream and 0.005% ointment formulations for the acute and maintenance treatment of patients with dermatological disorders such as atopic dermatitis, psoriasis and vitiligo. This glucocorticoid is characterized by high lipophilicity, high glucocorticoid receptor binding and activation, and a rapid metabolic turnover in skin. Although skin blanching following fluticasone propionate exceeds that of corticosteroids of medium strength, several clinical trials demonstrate a low potential for cutaneous and systemic side-effects, even in difficult-to-treat areas like the face, the eyelids and intertriginous areas. Even among paediatric patients with atopic dermatitis, fluticasone propionate proved to be safe and effective. These pharmacological and clinical properties are reflected by the high therapeutic index of this glucocorticoid