Plasticised regenerated silk/gold nanorods hybrids as sealant and bio-piezoelectric materials

Manual and mechanical suturing are currently the gold standard for bowel anastomosis. If tissue approximation fails, anastomotic leaks occur. Anastomotic leaks may have catastrophic consequences. The development of a fully absorbable, biocompatible sealant material based on a bio-ink silk fibroin can reduce the chance of anastomotic leaks. We have produced a Ca-modified plasticised regenerated silk (RS) with gold nanorods sealant. This sealant was applied to anastomosed porcine intestine. Water absorption from wet tissue substrate applied compressive strains on hybrid RS films. This compression results in a sealant effect on anastomosis. The increased toughness of the hybrid plasticised RS resulted in the designing of a bio-film with superior elongation at break (i.e., ≈200%) and bursting pressure. We have also reported structure-dependent piezoelectricity of the RS film that shows a piezoelectric effect out of the plane. We hope that in the future, bowel anastomosis can be simplified by providing a multifunctional bio-film that makes feasible the mechanical tissue joint without the need for specific tools and could be used in piezoelectric sealant heads

The Line Emission Region in III Zw 2: Kinematics and Variability

We have studied the Ly-al, Hbeta, Halpha and Mg II2798 line profiles of the Seyfert 1 galaxy III Zw 2. The shapes of these broad emission lines show evidence of a multicomponent origin and also features which may be identified as the peaks due to a rotating disk. We have proposed a two-component Broad Line Region (BLR) model consisting of an inner Keplerian relativistic disk and an outer structure surrounding the disk. The results of the fitting of the four Broad Emission Lines (BELs) here considered, are highly consistent in both the inner and outer component parameters. Adopting a mass of approx. 2 E8 sollar masses for the central object we found that the outer radius of the disk is approximately equal for the four considered lines (approx 0.01 pc). However, the inner radius of the disk is not the same: 0.0018 pc for Ly-alpha, 0.0027 pc for Mg II, and 0.0038 pc for the Balmer lines. This as well as the relatively broad component present in the blue wings of the narrow [OIII] lines indicate stratification in the emission-line region. Using long-term Hbeta observations (1972-1990, 1998) we found a flux variation of the BEL with respect to the [OIII] lines.Comment: ApJ, accepted, 22 pages, 10 figure

LCrowdV: Generating Labeled Videos for Simulation-based Crowd Behavior Learning

We present a novel procedural framework to generate an arbitrary number of labeled crowd videos (LCrowdV). The resulting crowd video datasets are used to design accurate algorithms or training models for crowded scene understanding. Our overall approach is composed of two components: a procedural simulation framework for generating crowd movements and behaviors, and a procedural rendering framework to generate different videos or images. Each video or image is automatically labeled based on the environment, number of pedestrians, density, behavior, flow, lighting conditions, viewpoint, noise, etc. Furthermore, we can increase the realism by combining synthetically-generated behaviors with real-world background videos. We demonstrate the benefits of LCrowdV over prior lableled crowd datasets by improving the accuracy of pedestrian detection and crowd behavior classification algorithms. LCrowdV would be released on the WWW

Validity of the rigid band picture for the t-J model

We present an exact diagonalization study of the doping dependence of the single particle Green's function in 16, 18 and 20 site clusters of t-J model. We find evidence for rigid-band behaviour starting from the half-filled case: upon doping, the topmost states of the quasiparticle band observed in the photoemisson spectrum at half-filling cross the chemical potential and reappear as the lowermost states of the inverse photoemission spectrum. Features in the inverse photoemission spectra which are inconsistent with rigid-band behaviour are shown to originate from the nontrivial point group symmetry of the ground state with two holes, which enforces different selection rules than at half-filling. Deviations from rigid band behaviour which lead to the formation of the `large Fermi surface' in the momentum distribution occur only at energies far from the chemical potential. A Luttinger Fermi surface and a nearest neighbor hopping band do not exist.Comment: Remarks: Revtex file + 7 figures attached as compressed postscript files Figures can also be obtained by ordinary mail on reques

The quasar main sequence and its potential for cosmology

The main sequence offers a method for the systematization of quasar spectral properties. Extreme FeII emitters (or extreme Population A, xA) are believed to be sources accreting matter at very high rates. They are easily identifiable along the quasar main sequence, in large spectroscopic surveys over a broad redshift range. The very high accretion rate makes it possible that massive black holes hosted in xA quasars radiate at a stable, extreme luminosity-to-mass ratio. After reviewing the basic interpretation of the main sequence, we report on the possibility of identifying virial broadening estimators from low-ionization line widths, and provide evidence of the conceptual validity of redshift-independent luminosities based on virial broadening for a known luminosity-to-mass ratio.Comment: 5 pages, 2 figures, contribution presented at the IAU Symposium 356, Nuclear Activity in Galaxies Across Cosmic Time, held in Addis Ababa, Ethiopia, on Oct. 7-11, 2019. M. Povic et al. (Eds.

Hole-Hole Contact Interaction in the t-J Model

Using an analytical variational approach we calculate the hole-hole contact interaction on the N\'{e}el background. Solution of the Bethe-Salpeter equation with this interaction gives bound states in $d$- and p-waves with binding energies close to those obtained by numerical methods. At $t/J \ge 2-3$ the bound state disappears. In conclusion we discuss the relation between short range and long range interactions and analogy with the problem of pion condensation in nuclear matter.Comment: 11 pp. (LATEX), 7 figures (PostScript) appended, report N

The integrated academic information system support for education 3.0 in higher education institution: lecturer perspective

Education 3.0 has been implemented in many higher education institutions (HEIs). Education 3.0 has been directed the institution toward better educational experience. But on the other hands, the implementation of Education 3.0 also caused some problems. Previous research has found administrative problem experienced by the lecturer. This research explores deeper from the lecturer and suggested the solution from lecturer perspective, combined with information technology capabilities owned by the HEIs. The research used a case study as the method and conducted a qualitative research with a semi-structured interview. The interview analysis has found that the increase of the administrative processes is caused by online and offline administrative activities. The online activities are from e-learning and the offline activities are from traditional learning (face-to-face). The administrative processes also involved the academic information system (AIS). Simplified all of the administrative processes are more preferred. To overcome the problems, integrating the AIS and e-learning become necessary. This research suggests transforming the existing AIS into an integrated AIS and hopes the solution can simplify the administration process

SINEUPs: A novel toolbox for RNA therapeutics

RNA molecules have emerged as a new class of promising therapeutics to expand the range of druggable targets in the genome. In addition to 'canonical' protein-coding mRNAs, the emerging richness of sense and antisense long non-coding RNAs (lncRNAs) provides a new reservoir of molecular tools for RNA-based drugs. LncRNAs are composed of modular structural domains with specific activities involving the recruitment of protein cofactors or directly interacting with nucleic acids. A single therapeutic RNA transcript can then be assembled combining domains with defined secondary structures and functions, and antisense sequences specific for the RNA/DNA target of interest. As the first representative molecules of this new pharmacology, we have identified SINEUPs, a new functional class of natural antisense lncRNAs that increase the translation of partially overlapping mRNAs. Their activity is based on the combination of two domains: An embedded mouse inverted SINEB2 element that enhances mRNA translation (effector domain) and an overlapping antisense region that provides specificity for the target sense transcript (binding domain). By genetic engineering, synthetic SINEUPs can potentially target any mRNA of interest increasing translation and therefore the endogenous level of the encoded protein. In this review, we describe the state-of-the-art knowledge of SINEUPs and discuss recent publications showing their potential application in diseases where a physiological increase of endogenous protein expression can be therapeutic