Haemostasis and cardiovascular disease

The term 'coronary thrombosis' was derived from clinical and pathological observations on myocardial infarction made at least 80 years ago' and perhaps even earlier.'·} It was probably not until the 1930s that clinically manifest ischaemic heart disease in the form of myocardial infarction became a familiar condition rather than the unusual occurrence or even the rarity it had hitherto been. When the growing epidemic of clinical ischaemic heart disease prompted an increasing and concerted research programme after the Second World War, interest largely centred on the lipid nature of the atheromatous plaque and the contributions dietary fat intake and blood cholesterol levels make to it

Waar is de beste dokter?

Oratie uitgesproken door Prof.dr. J.G. van der Bom bij de aanvaarding van het ambt van hoogleraar in de in de Klinische Epidemiologie in het bijzonder Transfusie Geneeskunde leeropdracht MET hoofdlettersxx aan de Universiteit Leiden op vrijdag 23 januari 2015LUMC / Geneeskund

Hepatic cyst infection following aspiration sclerotherapy: a case series

Contains fulltext : 138159.pdf (publisher's version ) (Open Access)Mass-related symptoms caused by hepatic cysts are effectively treated by aspiration sclerotherapy (AS). This minimal-invasive intervention is regarded as a safe procedure. Hence, occurrence of complications is low. Transient fever is commonly reported as a side effect. However, documentation on a post-procedural hepatic cyst infection as a complication of AS is limited. We present five cases in which a tentative diagnosis of post-procedural hepatic cyst infection was made. Patients typically presented with abdominal pain and fever, had to be admitted to our hospital, and were treated with long term antibiotics. Ultimately, the cyst infection successfully resolved with ciprofloxacin in all cases

Study protocol and pilot results of an observational cohort study evaluating effect of red blood cell transfusion on oxygenation and mitochondrial oxygen tension in critically ill patients with anaemia: the INsufficient Oxygenation in the Intensive Care Unit (INOX ICU-2) study

INTRODUCTION: The recently developed protoporphyrin IX-triple state lifetime technique measures mitochondrial oxygenation tension (mitoPO2) in vivo at the bedside. MitoPO2might be an early indicator of oxygen disbalance in cells of critically ill patients and therefore m

Neonatal management and outcome in alloimmune hemolytic disease

Research into fetal development and medicin

Back to base pairs: what is the genetic risk for red bloodcell alloimmunization?

Red blood cell (RBC) alloimmunization is a serious complication of blood transfusions, challenging selection of compatible units for future transfusions. Genetic characteristics may be associated with the risk of RBC alloimmunization and may therefore serve to identify high-risk patients. The aim of this systematic review was to summarize the available evidence on genetic risk factors for RBC alloimmunization. Electronic databases were searched up to April 2020 for studies (Search terms included transfusion, alloimmunization and genetic). A total of 2581 alloimmunized cases and 26,558 controls were derived from 24 studies. The alleles that were most frequently studied and that demonstrated significant associations in a meta-analysis with alloimmunization to the Duffya antigen were HLA-DRB1*04 (Odds Ratio 7.80 (95%CI 4.57-13.33)), HLA-DRB1*15 (OR 3.76 (95%CI 2.14-6.59)), and HLA-DRB1*03 (OR 0.12 (95%CI 0.05-0.29)). Furthermore, significant associations with anti-K formation was found for the alleles HLA-DRB1*10 (OR 2.64 (95%CI 1.41-4.95)), HLA*DRB1*11 (OR 2.11, (95% CI 1.34-3.32)), and HLA-DRB1*13 (OR 1.71 (95%CI 1.26-2.33)). Overall, the available evidence was of moderate to low quality, hampering interpretation of reported results. There is an urgent need for high quality evidence on genetic risk factors for RBC alloimmunization

The effect of a fibrin sealant on knee function after total knee replacement surgery. Results from the FIRST trial. A multicenter randomized controlled trial

Clinical epidemiolog